Haopeng Wang @HaopengWang_Lab
Associate Professor at ShanghaiTech University, specializing in T cell signal transduction and engineering. Expertise in designing CAR-T, TCR-T, and CAR-Treg. scholar.google.com/citations?hl=e… Shanghai, CHINA Joined February 2023-
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Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell. nature.com/articles/s4158…
What a beautiful study from Dr. Bernard Malissen! A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo rupress.org/jem/article/22…
In the latest issue! Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs dlvr.it/TKZSzG
Congrats to Xinyao and Xie Chen! In eukaryotes, multiple transcription factors bind cooperatively to a regulatory region on genomic DNA to control gene expression. In this paper (bit.ly/3GV1BoP), we present an experimental metric for quantifying such cooperativity.
Understanding LAG3 immune checkpoint function nature.com/articles/d4157…
Just out in @CellCellPress! Prof. Kai W. Wucherpfennig previews our study: “Unlocking LAG3: Ubiquitin’s Unexpected Role.” LAG3's non-degradative poly-Ub by Cbl ligases flips this checkpoint ON and marks TILs that respond to PD-1/LAG3 combo therapy. cell.com/cell/fulltext/…
Science Spotlight: New insight into LAG3's checkpoint function, a blood-based T cell assay for Type I diabetes, a degrader using a new E3 ligase, and paper from newcos. BioCentury's roundup of translational innovations buff.ly/RYy1W0J
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function. @HaopengWang_Lab found ubiquitination of LAG3 promotes its inhibitory function rather than its degradation, and is required for suppression of antitumor immunity in vivo. ow.ly/xOKh50VkhNt
Just published a review on CAR-T tonic signaling and introduced the "Peak Theory"—finding the optimal signaling level to overcome T-cell exhaustion and enhance efficacy in cancer, autoimmune diseases, and more. link.springer.com/article/10.100… #Immunotherapy #CART
D-STAR: The Gemini Guardians redefining dual-targeting of immune cell ... sciencedirect.com/science/articl…
Now online! Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs dlvr.it/TJZsP5
Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading…
Glad to share our new publication @ImmunityCP , reporting a new E-CAR that can form mature immunological synapse through phase separation. Paper link: authors.elsevier.com/a/1kATc_OR%7Ey…
🔬 Thrilled to share our new paper in @ImmunityCP with @ChenqiXuSH ! Novel Phase-CAR that promotes phase separation forms mature immunological synapses & shows enhanced anti-tumor activity. #CARTcell cell.com/immunity/fullt…
Important perspective in @NatRevImmunol on the Basic-Rich Sequence (BRS) signaling motif from Dr. Chenqi Xu's Lab! Fascinating to see how this charge-based motif in immunoreceptors and membrane proteins plays such a broad role in immune response regulation.
Important perspective in @NatRevImmunol on the Basic-Rich Sequence (BRS) signaling motif from Dr. Chenqi Xu's Lab! Fascinating to see how this charge-based motif in immunoreceptors and membrane proteins plays such a broad role in immune response regulation.
Excited to share our Research Highlight for a recent study published in @NEJM! The "Hangzhou Protocol" is a major leap in treating T-cell leukemia! 🚀No chemo or immunosuppressants are needed! link.springer.com/article/10.103… #Hematology #CancerTreatment #CAR_T #NEJM
Happy to share our 1st TCR-T therapy study with Dr. Chenqi Xu, published in Cell Chemical Biology: Transient Hydroxycholesterol Treatment Promotes Long-term TCR-T Efficacy! cell.com/cell-chemical-… #Immunotherapy #TCRTCells #CancerResearch #CARTCells #TCellTherapy #Innovation
Just shared insights on the PEAK Theory of CAR-T tonic signal in our latest commentary! This theory not only sharpens our understanding of metabolic processes in #CARTCells but also guides the optimization of CAR-T therapies. #CellTherapy #Immunotherap nature.com/articles/s4225…
PD-1 and its ligands dimerize in cis via transmembrane domain interactions to enhance T cell inhibition @jwang133 @SciImmunology @MichaelLDustin science.org/doi/10.1126/sc…
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Mélanie Tichet @MelanieTichet
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Santiago Carmona 🧬... @carmonation
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Dr. Michelle Krogsgaa... @DrKrogsgaard
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754 Followers 444 Following We focus on the Cell & Mol mechanisms that drive onset, maintenance, and resolution of the imm resp towards pathogens. (Not actively maintained)
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nature @Nature
2.6M Followers 3K Following Research, News, and Commentary from Nature, the international science journal For daily science news, get Nature Briefing: https://t.co/wGmQlQ8a4D
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3K Followers 488 Following Group leader at GIMM, Professor @Medicina_Lisboa, President @SImunologia. Fanatic about T cells, Cinema, Travel, Sports.
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2K Followers 3K Following 消化器内科医・モナドロジスト・医学博士・数学修士・岡崎能久 MD・PhD・MS 東北大学医学部(1-2年）大阪大学医学部3年次編入卒 千葉大学数学科・大阪大学大学院修士（数学）近畿大学病院・羽曳野医療センターetc勤務 岡山県金光学園中高卒 広島県福山市鞆町(岡崎雄志郎宅) 中高数学専修免許 医師免許(2001）
Trends Cell Biology @TrendsCellBio
24K Followers 197 Following Trends in Cell Biology is a leading reviews journal covering the latest advances in cell biology. Automatic posting by https://t.co/yxzayn2sCU Blusky handle cp-trendscellbio
UCSD BioSciences @ucsdbiosciences
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