Marcus Hartmann @HartmannLab
Structural Biochemistry @MPI_Bio & @UNI_TUE Understanding and Manipulating Molecular Machines eb.mpg.de/protein-evolut… Tuebingen, Germany Joined June 2020-
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Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome!
Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome! https://t.co/VjOHbQHCgD
We just released the "protein design toolkit", integrating tools from Damietta, ProteinMPNN and OpenMM. An interactive tutorial is available at the server damietta.de. Recommended usage is described in the paper: doi.org/10.1093/nar/gk… and feedback is most welcome!
😁🎉😄🌟#NobelPrize!🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃😊🏆😁#PhysicsNobelPrize2023 for Ferenc Krausz, Max Planck Institute of Quantum Optics! 🎊😃🥰😆🥳😁😃🎉🏅😊🎈😁🥳😄🎊😁🌟😃🥰🏆😁🎉🎇😊🥳😄🌟🎈😁😃🥰🎉🏆😁🎊😊😄🥳🌟🎇😁🥰😃🎉🎈😁🏆😊😄🎊🥳😁🌟😃🥰🎉🏅😁🎈😊🥳😄🎉😁😍😁🎉🎇😊🥳😄🌟🎈🏆
Sleeves up for infection research: Our postdoc Joe Joiner researches anti-infectives to prevent #Salmonella infection. He’s not only appreciated as a talented researcher, but also as a great teacher by his students! @PAW_Germany #PostDocAppreciationWeek @MPI_Bio
It’s #FluorescenceFriday so some #RealTimeChem from my lab: purification (until battery crashed) of a fluorescently labelled non-chiral, non-glutarimide/uracile CRBN ligand with outstanding affinity. #TPD tweeps, it will blow your mind 🤯 next step: in vitro assays @HartmannLab
📢New preprint: multidimensional design of benzamide CRBN binders & #PROTACs - #TPD tweeps will surely enjoy the MedChem journey: binding data, X-ray structures, reactivity screens, neosubstrate-sparing degraders, cool synthetic methods. 1/4 👉 ChemRxiv doi.org/10.26434/chemr…
A press release about our recent paper in @PNASNews pnas.org/doi/10.1073/pn… Cyanobacterial protein integrates the circadian clock information growkudos.com/publications/1… via @GrowKudos @uni_tue_exstra @CoE_CMFI @MPI_Bio
Great to see this out! Enormous MedChem efforts led to new SAR aspects of VHL ligands 🧪💊 #TPD bigs thanks to @alessiociulli +team & @IzidorSosic +team and colleagues from @UniBonn
Great to see this out! Enormous MedChem efforts led to new SAR aspects of VHL ligands 🧪💊 #TPD bigs thanks to @alessiociulli +team & @IzidorSosic +team and colleagues from @UniBonn
Fun fact: At 1.06 Å, this is the first-ever structure of any histone protein determined at atomic resolution - for what it's worth! 🤣 doi.org/10.1101/2023.0…
Congrats, truly seminal work! Since our initial discovery of bacterial histones, we too worked on the very same histone protein & now present its crystal structure & DNA-binding properties. Great work by Yimin, Birte & collaborators @HartmannLab @MPI_Bio doi.org/10.1101/2023.0…
Congrats, truly seminal work! Since our initial discovery of bacterial histones, we too worked on the very same histone protein & now present its crystal structure & DNA-binding properties. Great work by Yimin, Birte & collaborators @HartmannLab @MPI_Bio doi.org/10.1101/2023.0… https://t.co/h61rPlGq4a
An excellent perspective by authors from @AstraZeneca about fragment-based approaches to identify ligands for E3 ligases. Of especially high relevance for the field of targeted protein degradation (#TPD). @ACSBioMed pubs.acs.org/doi/10.1021/ac…
Check out our work on regulating #Salmonella virulence @biorxivpreprint! Great job by Joe, Wieland, Thales, @BangeBalcony, @atposo & @samuwag: HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids. biorxiv.org/content/10.110…
After long time in oven, happy to share w/ @HartmannLab @PNASNews our work #Cyanobacteria #Carbon #Sensor SbtB possesses atypical #Redox regulated #Apyrase (hydrolysing ATP/ADP) to control HCO3 transport Generous fund by @uni_tue_exstra @CoE_CMFI @MPI_Bio pnas.org/doi/10.1073/pn…
🧪Happy to share our work on three-branched CRBN ligands for MG and #PROTACs design. A multicomponent reaction as synthetic entry🤯Nice work by my PhD student Robert and @KroenkeLab @HartmannLab at the interface between Chemistry & Biology. #OpenAccess rsc.li/3wfEtJg
🚨PhD alert just before Xmas 🎅 My lab offers a PhD position within the @grk2873 funded by @dfg_public The project is devoted to #PROTACs and E3 ligand #chemistry #lifesciences For more information visit our website 👇👇 and apply! Please help & retweet!
🚨PhD alert just before Xmas 🎅 My lab offers a PhD position within the @grk2873 funded by @dfg_public The project is devoted to #PROTACs and E3 ligand #chemistry #lifesciences For more information visit our website 👇👇 and apply! Please help & retweet!
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines sciencedirect.com/science/articl…
🥳🥳 Congrats, great job! 🥳🥳 Fantastic PhD defense by Joe this week, showcasing great results from your collaborative salmonella anti-virulence project with @samuwag @atposo @BronstrupLab! #Salmonella, beware of Joe! @phd_reps_MPI_DB
We couldn't agree more - this is a fascinating topic and we are more than happy to provide the structural basis for the recognition of the C-terminal cyclic imide #degron in our new communication @BBRCME: sciencedirect.com/science/articl…
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