Isaac Vidal, MSc🔬🧬🧫 @IsaacVidalPar
Bioscientist 🔬🧬👁️🐁 | PhD in Neurosciences candidate at Di Polo Lab @UMontreal | He/him instagram.com/isaacbiosci Montréal, Québec Joined June 2017-
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Isaac Vidal, MSc🔬🧬🧫 retweeted
Human genetics is at an exciting phase. Combined with deep molecular profiling, it's uncovering disease biology, opening avenues for drug development. Here are some noteworthy case studies from last weeks showing how genetics & omics can guide target discovery & validation👇
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Isaac Vidal, MSc🔬🧬🧫 retweeted
Can you rejuvenate an old brain by giving it young immune cells? 🧠 My lab @calico put it to the test. In our new study, we replaced the brain's immune cells in old mice with young ones. The result? The old brain environment forced the young cells to age RAPIDLY. A 🧵👇
Isaac Vidal, MSc🔬🧬🧫 retweeted
Core metabolic pathways Source & PDF Download Bibel, B., & The bumbling biochemist. (2024). Core Metabolic Roadmap. Zenodo. Free Download zenodo.org/records/133697…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Sensory neurons shape local macrophage identity via TGF-β signaling @ImmunityCP cell.com/immunity/fullt…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Scientists in training should be taught the creative scientific process, to gain confidence in their self-efficacy for research and identity as a scientist, & also for greater work satisfaction and a chance of staying in science. Join our community at night-science.org
Isaac Vidal, MSc🔬🧬🧫 retweeted
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia @Nature nature.com/articles/s4158…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis - Fumadó Navarro - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/full/10.10…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Examination of post-mortem brain tissue from COVID-19 patients revealed severe inflammation, gliovascular failure, and microglial dysfunction, particularly in the medulla. 1/
Isaac Vidal, MSc🔬🧬🧫 retweeted
Toxic amyloid-β induces oxidation & fragmentation of mitoDNA in microglia, facilitating B-to-Z conformational transition that activates ZBP1-RIPK1 driven neuroinflammation in #Alzheimer's @ImmunityCP 🇨🇳 cell.com/immunity/fullt…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia…
Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia… https://t.co/15jmratqRT
Isaac Vidal, MSc🔬🧬🧫 retweeted
I'm excited that @Jjiyeon_lee's 2nd paper from the lab is out in @NatureAging. We found that the circadian gene REV-ERBalpha regulates brain NAD+ by controlling CD38 in astrocytes. REV-ERB KO or pharmacologic inhibition mitigates tau pathology in mice. nature.com/articles/s4358…
Isaac Vidal, MSc🔬🧬🧫 retweeted
After a long break, Scientistt has been rebranded to Founding Minds! It's a new platform dedicated to the scientists behind the world's most ambitious startups. Be the first to read conversations with scientist founders at the helm of leading startups ➡️ founding-minds.net
Isaac Vidal, MSc🔬🧬🧫 retweeted
DgeaHeatmap: An R Package for Transcriptomic Analysis and Heatmap Generation. #Transcriptomics #Heatmaps #Genomics #R academic.oup.com/bioinformatics…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Basic summary of biochemistry
Isaac Vidal, MSc🔬🧬🧫 retweeted
Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis @NatImmunol @nalatrak nature.com/articles/s4159…
Isaac Vidal, MSc🔬🧬🧫 retweeted
Making Your Research Free May Cost You * Scientists say they are stressed about spending thousands of grant dollars on unexpected and questionable open-access charges. By @stephaniemlee for @chronicle chronicle.com/article/making…
Isaac Vidal, MSc🔬🧬🧫 retweeted
How to read an academic paper
Isaac Vidal, MSc🔬🧬🧫 retweeted
STARNet enables spatially resolved inference of gene regulatory networks from spatial multi-omics data biorxiv.org/content/10.110…
Isaac Vidal, MSc🔬🧬🧫 retweeted
If this was a drug, it would be a blockbuster prevention vs Alzheimer's disease for APOE4 homozygotes, with 35% reduction of risk!
If this was a drug, it would be a blockbuster prevention vs Alzheimer's disease for APOE4 homozygotes, with 35% reduction of risk! https://t.co/wMFFJvwU8L
Isaac Vidal, MSc🔬🧬🧫 retweeted
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