everything we’ve been told about aging may be wrong scientists just discovered that the “biological clock” tracking your aging isn’t actually controlling it, it’s just reporting the damage. the real driver of aging are permanent dna mutations 1/
for years, researchers have treated epigenetic clocks (DNA methylation patterns that correlate with age) as a fundamental driver of aging itself. the assumption: reset the clock, reset aging. but what if the clock is just a byproduct of dna damage? 2/
@IterIntellectus this is not entirely accurate reporting of the actual science. The discovery was the cross talk between the two types of aging, no where did it say that epigenetic aging was not underminded by this, just that DNA mutation can be both affected by and affect it.
@IterIntellectus Isn’t this a widely held school of thought? That DNA damage is aging? Long term effects of sunlight on the skin teaches us this. Stem cells have robust DNA repair mechanisms: • base excision repair (BER) • nucleotide excision repair (NER) • homologous recombination (HR)
@IterIntellectus Next you’ll tell me mechanical clocks don’t control the time, and only report its passage!
@IterIntellectus It sounds like environmental control systems that adjust our surroundings to minimize exposure to DNA-damaging agents like radiation, pollutants, and chemicals could be huge for aging
I'm skeptical about this because each cell in your body gets its own unique set of DNA mutations, and they tend to accumulate linearly over time. Aging is extremely nonlinear (nobody is older than 130!) and quite uniform across the body. So something is probably wrong with this.
@IterIntellectus 🙏🏻 good to see some action in this field, we still don't truly know why we age, the simulated AI trials coming soon will open the door
@IterIntellectus Sounds complicated. Upload time
@IterIntellectus As well as what’s required , reverse aging is in reach
@IterIntellectus we've been treating the smoke alarm as the fire all along. turns out aging is more like a bug in our genetic code than a ticking clock
@IterIntellectus I'm surprised this is novel - I always assumed aging was progressive DNA damage that's impossible to repair without nanobots to repair in the bloodstream. It's not that different from entropy in mechancial systems. Like a car's frame rusting over time.
@IterIntellectus In school I've learnt that perfect genom replication is very energy-demanding (high entropy export) and we have thus evolved to do that only for reproductive (egg, sperm) cells. For other cells, the copy of the copy of the copy of the genom is it some point no longer good enough.
@IterIntellectus I kinda like this vittorio paper poasting, keep it up
@IterIntellectus Hyperbaric oxygen therapy can reverse a lot of damage, as can diet, sunshine, motion. Hair will regrow. Skin tone return. Mental acuity improve. I believe we can live far longer and healthier than 'current thinking' promotes.
@IterIntellectus this guy vitorrio plugging into gpt premium, and telling it to "analyze this paper and design a tweet thread". shitt I should do the same.
@IterIntellectus Well, while still under development, it's theoretically possible to reverse DNA damage. Crispr-Cas9 is just an example. For sure, it'll be harder and more risky, but still "doable"
@IterIntellectus The first answer is to breed better and breed earlier.
@IterIntellectus What if at age 24 I 23andMe’d my DNA, downloaded the raw file, and plan to CRISPR my DNA back to state at 24 by doing a differential compare to my aged state?