John Patrick Stein @JPSwcpmc
Family Physician with great interest in Preventative Cardiology. Looking at the best science to identify risk and treat it prior to stroke and heart attack. johnpatricksteinmd.com St. Louis Joined October 2013-
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John Patrick Stein retweeted
🚨 FDA expands approval of Repatha® (evolocumab) for adults at risk of CV events from uncontrolled LDL-C—even without established CVD. Now approved as monotherapy for HoFH. Important update for clinicians managing FH patients. #KnowFH #KnowHoFH @Amgen prnewswire.com/news-releases/…
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Looking forward to potentially exciting results in properly powered phase 3 trial🤞
Looking forward to potentially exciting results in properly powered phase 3 trial🤞
John Patrick Stein retweeted
🚨 New release! The 2025 Focused Update of the 2019 ESC/EAS Guidelines on dyslipidaemia management is out. Latest evidence → better prevention & treatment of ASCVD. 🔗 lnkd.in/eyfVrsJS #Cardiology #EAS #ESC #Dyslipidaemia
John Patrick Stein retweeted
🚨 Breaking from #ESC2025 🚨 New ESC/EAS dyslipidemia guidelines: 🔹 Lp(a) now a risk modifier beyond SCORE2 🔹 New cut off: ≥50 mg/dL (≈105 nmol/L) A big step forward for personalised CV risk assessment and prevention #LipoproteinA #Dyslipidemia #CVD #CVH
John Patrick Stein retweeted
👉GAELp(a) Registry – ESC Congress 2025, Madrid 🇦🇷 First results from the Argentine National Registry on Lp(a) and Cardiovascular Risk (GAELp(a)): 🔹 Elevated Lp(a) in 31.4% of the cohort 🔹 Associated with higher risk of CAD, PAD and MACE 🔹 Independent predictor of…
John Patrick Stein retweeted
👉Lp(a) and Cardiovascular Disease: unveiling the challenge From epidemiology & pathophysiology (@grsoffer) ➡️ risk management (@BNordestgaard) ➡️ clinical cases (I. Gouni-Berthold) ➡️ emerging therapies (S. Nissen) ➡️ conclusions (J.L. Zamorano). A comprehensive journey…
John Patrick Stein retweeted
🧬New study in @ATHjournal confirms: routine Lp(a) testing improves #cardiovascular risk stratification & saves costs. Routine testing reclassifies 20% as high-risk, prevents #CVD events & saves costs across #health systems. Read the study: shorturl.at/1tTCG
Would suggest checking a lipoprotein (a) or Lp(a) level if not already done.
Would suggest checking a lipoprotein (a) or Lp(a) level if not already done.
John Patrick Stein retweeted
Today I had the good fortune to meet and counsel Vishnu Priya Pulipati, MD, FACE, DiplABCL who is an internist/endocrinologist/lipidologist who also did a preventive cardiology fellowship with the great @mdavidsonmd and now practices in Tulsa, OK. She has an incredible CV for a…
Very interesting. What was the HDL variant and is it tied to any specific HDL function? What additional therapy did you offer?
Very interesting. What was the HDL variant and is it tied to any specific HDL function? What additional therapy did you offer?
They do individualize comments to consider patients with elevated Lp(a).
They do individualize comments to consider patients with elevated Lp(a).
John Patrick Stein retweeted
John Patrick Stein retweeted
We have now developed methods to measure OxPL on most lipoproteins, in addition to @OxPL_apoB and OxPL-apo(a). One applications is in ALS (Lou Gehrig's disease), with OxPL-apoE being most interesting. Of course, this also has treatment implications by overexpressing OxPL…
We have now developed methods to measure OxPL on most lipoproteins, in addition to @OxPL_apoB and OxPL-apo(a). One applications is in ALS (Lou Gehrig's disease), with OxPL-apoE being most interesting. Of course, this also has treatment implications by overexpressing OxPL… https://t.co/qCNvCgxQVd
John Patrick Stein retweeted
@JoshJwageman @ApoDudz @ethanjweiss @JohnKastelein @DrScottMurray @lipo_fan Thus could set the stage for apoA-I to enter cross BBB, enter the matrisome and rescue dysfunctional apoE4-HDLs.
John Patrick Stein retweeted
Nice new article on the impaired lipid transport characteristic of APOE4 carriers @Drlipid @ApoDudz @ethanjweiss @JohnKastelein @DrScottMurray @lipo_fan x jlr.org/article/S0022-…
John Patrick Stein retweeted
In data from the UK Biobank, higher Lp(a) concentrations were associated with incident extracoronary atherosclerotic vascular disease (both peripheral arterial disease & carotid artery stenosis) and progression to major adverse limb events or stroke. ahajournals.org/doi/full/10.11…
John Patrick Stein retweeted
🎯 Precision Lipidology Enters the RNA Era Small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) are reshaping lipid management by targeting mRNA degradation at the source. 👉Inclisiran targets PCSK9 → ↓LDL-C 👉Volanesorsen, Olezarsen, Plozasiran target…
John Patrick Stein retweeted
Lp(a) as a Prognostic Marker of ASCVD Progression New study with 460k participants showed that: 1️⃣ Median Lp(a) Levels: 1) No Vascular Disease: 19.5 nmol/L 2) Incident PAD: 25.3 nmol/L 3) PAD to MALE: 33.3 nmol/L 4) Incident Carotid Stenosis: 29.5 nmol/L 5) Carotid Stenosis to…
John Patrick Stein retweeted
Spotty calcification is positively associated with features of plaque vulnerability, such as lipid-rich plaque and macrophage 🔗atherosclerosis-journal.com/article/S0021-… @society_eas #EASSoMe
John Patrick Stein retweeted
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