Jan Mathony @JanMathony
Scientist with a passion for Synbio | Protein engineering | Optogenetics niopeklab.de/mathony-lab/ Joined April 2018-
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Jan Mathony retweeted
ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins. nature.com/articles/s4159…
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Publication alert: Our paper on domain insertion predictions in proteins is now out in @naturemethods in its final form: rdcu.be/ey7w3 Also check out the nice perspective by Noah Holzleitner and Julian Grünewald: nature.com/articles/s4159…
Jan Mathony retweeted
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
Jan Mathony retweeted
Excited to share my main PhD work is finally out! 🥳 We built a phage-assisted evolution platform to evolve allosteric protein switches (POGO-PANCE) and introduce cumulative, targeted mutations/Indels (RAMPhaGE)! See how we evolved strong, light-switchable AraC variants:
Excited to share my main PhD work is finally out! 🥳 We built a phage-assisted evolution platform to evolve allosteric protein switches (POGO-PANCE) and introduce cumulative, targeted mutations/Indels (RAMPhaGE)! See how we evolved strong, light-switchable AraC variants:
Jan Mathony retweeted
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @amanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…
Jan Mathony retweeted
Modular Engineering of Thermo-Responsive Allosteric Proteins biorxiv.org/content/10.110… #biorxiv_synbio
Jan Mathony retweeted
In @Nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ @RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed nature.com/articles/s4158…
Jan Mathony retweeted
We are looking for a new PhD student to join our lab of Neuroepigenetics at EPFL! Interested in deciphering the epigenetic mechanisms of memory formation, storage and change?🧠🧬Check out the specifics here: graefflab.epfl.ch
We have an exciting new PhD opportunity! If you are fascinated by proteins and their dynamics and want to engineer them to develop new molecular tools: apply now! We are a young and dynamic team combining state of the art laboratory and bioinformatics approaches. Please share.
Jan Mathony retweeted
So excited to announce that our study on the development and evolution of pallial cell types and structures in birds led by @BassiZaremba is now out in @ScienceMagazine! science.org/doi/10.1126/sc… PS: this is our last post here – please follow us to where the sky is blue!
Jan Mathony retweeted
Conducted by @ruedaeneritz, we have seen that pallial neurons are generated in different regions and stages of the embryonic brain🐣🦎🐀: pallial neurons and circuits have evolved separately. Evolutionary CONVERGENCE of neurons and circuits! shorturl.at/PlWGR
I am super excited and grateful to be funded by the @bwstiftung within the Postdoc Elite Program. Looking forward to bringing exciting new research from the drawing board into the lab. Many thanks to all my amazing colleagues for all the continued collaboration and support!
Interested in allosteric protein switches? Check our ProDomino - our new model for the prediction of domain insertion sites. With ProDomino we engineered several potent inducible proteins including Cas9 and Cas12a variants. biorxiv.org/content/10.110…
Jan Mathony retweeted
📣PhD Opportunity in Synthetic Cell Engineering! Become part of the @ComeInCell Marie Curie International Training Network and dive into research at the intersection of biophysics, biomedicine, membranes, condensates and caner immunology. @Leibniz_INM comeincell.org/dc04-synthetic…
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