SunLab @JiSunLab
The Sun Lab | Dept. of Biological Science @ National University of Singapore jisunlab.com Joined September 2019-
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My lab #NUS is located at the place near the arrow. My daily walk to the lab feels like stepping into the applewood Wardrobe in Narnia.
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Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating nature.com/articles/s4142…
SunLab retweeted
A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience pnas.org/doi/10.1073/pn…
Congratulations, Hongbo!!!
Congratulations, Hongbo!!!
SunLab retweeted
Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. ow.ly/77Yl50VGpKe
Congratulations 🎉, @JunminPengLab
Congratulations 🎉, @JunminPengLab
SunLab retweeted
Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy go.nature.com/41AWsZX
SunLab retweeted
Complex water networks visualized by cryogenic electron microscopy of RNA, done by @RDasLab, @kaiming_zhang, @chiulab nature.com/articles/s4158…
SunLab retweeted
Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:nature.com/articles/s4146… @JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers
Congratulations 🎉 to @LabZheng for the two back-to-back stories on UM171 molecular glue. nature.com/articles/s4158…; nature.com/articles/s4158…
Interesting work from @TheHurleyLab
congratulations, Christoph.
congratulations, Christoph.
SunLab retweeted
Transport mechanism and structural pharmacology of human urate transporter URAT1 | Cell Res doi.org/10.1038/s41422…
We are happy to announce the public release of EMhub, a web platform designed to support the operations of a scientific facility, enabling easy management of users, instruments, bookings, and project tracking. EMhub was unveiled at the #ACA2024 last week by @delarosatrevin
SunLab retweeted
Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…
Our collaboration with @WillPPK on NOX5 is out. We captured NOX5 in different activation states, and used MD simulation to explore the initiation of electron transfer. An unexpected Zn finger was also identified that is critical for function. nature.com/articles/s4146…
Congratulations, Suzanne! @pfeffersuzanne
Congratulations, Suzanne! @pfeffersuzanne
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