Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein biorxiv.org/content/10.110…
Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…
Together with labs of @brian_b_liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. biorxiv.org/content/10.110…
Finally! Many thanks to my Ph.D. supervisor Dr. Xinzheng Zhang and my labmate Ph.D. candidate Chunling Wu. Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames cup.org/3hg2bxN
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Drug discovery, targeted protein degradation, small molecule synthesis
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272 Followers 1K FollowingPh.D in Chemical Biology @PKU1898. From Chemists to Biologist, JCC Postdoctoral Fellow in Broad Institute of Harvard and MIT @BoXia7 lab.
328 Followers 771 FollowingMed Chem & Chem Bio Scientist | Building better prodrugs & ADCs - Making molecules that matter | Current Postdoc@UCL🇬🇧 | Former PhD student@IISER Pune🇮🇳
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