Jakub Chrustowicz @chrustowicz_j
Postdoc at @MPI_Biochem | Schulman lab dissecting molecular mechanisms of GID/CTLH E3 ligases München, Bayern Joined June 2019-
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Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF
Can we turn the activity of oncogenic kinases against cancer itself? In my postdoc work @Stanford, new in @ScienceMagazine, we show exactly that. science.org/doi/10.1126/sc… #ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed
🔬 Neat discovery in protein degradation. Gray, Schulman, et al labs unveil ZZ1, a prodrug for charged molecular glues that target disease-causing proteins via the GID/CTLH ubiquitin ligase complex. biorxiv.org/content/10.110…
⭐️ Editor's Choice article: Mutations in WDR26 associated with #SkrabanDeardorffsyndrome (#SKDEAS) impair CTLH E3 complex assembly ➡️ doi.org/10.1002/1873-3… @pjmurray_lab @MPI_Biochem
Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in @MolecularCell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, @dawafutisherpa, @ArnoAlpi Schulman lab @MPI_Biochem
Wow! CUL9 is a GIANT E3 ubiquitin ligase! See unique cullin-RING-RBR all-in-one. +/- NEDD8. Now online in Nature Structural & Molecular Biology by Schulman Department ❕nature.com/articles/s4159… #ubiquitin #E3ligase #cryoEM @DHornGhetko @LinusHopf @labs_mann @NatureSMB
🚨Excited to share that our manuscript is now published in @NatureSMB. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome. @MPI_Biochem @HarvardCellBio @ASAP_Research nature.com/articles/s4159…
Here is the link to our SKDEAS paper: 10.1002/1873-3468.14866. And I love this figure. Maybe useful for the @skDeas.org effort.
Now out in @MolecularCell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM @MPI_Biochem @UNLV_CoS @StJudeResearch @DanielS20127197 @rajanprabu (1/2)
How does multisite #phosphorylation configure the catalytic E2-E3 assembly for metabolic enzyme targeting? Check out our story available now in its final version in @MolecularCell! ❕cell.com/molecular-cell… @chrustowicz_j @dawafutisherpa #ubiquitin
How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in @MolecularCell! ➡️ cell.com/molecular-cell… @dawafutisherpa Schulman lab @MPI_Biochem
Which cullin-RING E3 #ubiquitin ligase directs your favorite pathway or your #DegraderDrug? Our conformation specific antibody and probing of active #CRL E3 complexes is in @nchembio! ❕mpg.pulse.ly/3m3asipuew ❕nature.pulse.ly/l6c644umev @labs_mann @pjmurray_lab @LukasHenneberg
In preparation for the Louis-Jeantet Prize ceremony, we accompanied the @LouisJeantetFDN video team to shoot parts of the video about our director Brenda Schulman, @iDikic2 and their amazing research in the #ubiquitin field. Watch the full video here: ➡️ youtube.com/watch?v=UDBQOR…
Systemwide multiprotein complex formation visualized! CAND1 recycles Cullin-RING complexes to produce E3 #ubiquitin ligases. Averts cellular supply chain problems, prevents buildup of unneeded molecular machines & rapidly establishes degradation pathways ➡️tinyurl.com/bdnz25d6
📣 Amazing News! We're happy to announce, that Brenda Schulman receives an ERC Advanced Grant for her project UPSmeetMet! Congratulations to all ERC-Awardees! 🎉 ➡️ more: biochem.mpg.de/brenda-schulma… @ERC_Research #ERCAdG #Ubiquitin
Now Online C-degron mimicry confers E3 ligase selectivity dlvr.it/SkqCmx
#Ubiquitin ligase substrate selectivity regulated kinetically by E3 self-degron mimicry. International effort by Schulman lab, @DanielS20127197 Scott & Moeko King & team @StJudeResearch @KheewoongBaek @MPI_Biochem & Gary Kleiger @unlv ➡️ authors.elsevier.com/c/1gbyX3vVUPNx…
Mahendra Palecha @imshymaple
63 Followers 664 Following Living life is nothing but enjoying every moment.
Winnifred Runolfsdott... @WinnifredR78070
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Ferran José Duran @ferran_jose99
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Sheighrer @SheighrersoZ
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⌬ Dylan ⌬ @DyylaanL
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Canguo Piao @YongqingPark
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Ray Berkeley @ray_berkeley
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Sara J. Weaver, Ph.D. @sarajweaver
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Protein-Degraders @ProtDegraders
488 Followers 434 Following All things TPD! Protacs, molecular glues, ligases, proteasome, proximity induced
Roman Sarott @RomanSarott
802 Followers 1K Following PI at Max Planck Institute for Medical Research | Chemically Induced Proximity | Gain-of-Function | Stanford Postdoc | PhD 2021 ETH Zürich
Gyana Prakash Mahapat... @M_GyanaPrakash
1K Followers 1K Following Ph. D. Student @SchullerJM Lab @Uni_MR | Budding Structural Biologist | @McGillu Alumnus | #Photosynthesis🌱 #CryoEM❄🔬 #Biochemistry🧬
Malte Gersch @MalteGersch
397 Followers 266 Following Chemical Biologist & Research Groupleader at Max Planck & TU Dortmund. Interested in proteases, ubiquitin, the outdoors and more. https://t.co/NiwEqrr21H
Priyanka Dahate @PriyankaDahate
93 Followers 290 Following Graduate student at @GlattSebastian @Struc_biol_PL,Kraków & Biotechnology Specialist at @CaptorTherapeu1, Alumna @ccmb_csir, @HydUniv.
Pankaj Thapa @pankaj_thapa_
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Radek Nowak @RPNowak
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Mike Agius @10mM_Mike
194 Followers 479 Following Can we stop using 'undruggable'? | Degraders - MassTags | Proteomics | Senior Scientist @Parallelsqtech | @DanaFarber - Postdoc | @UMich - Ph.D 🏳️🌈
Jeffmarguilis @jeffmarguilis
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Woong Sub Byun @WoongSubByun
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Dan Nomura @DanNomura
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Zhe Zhuang @zhezhuang7
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Tichatef @TichatefX6UtA
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Mateusz C. Ambrożkie... @MAmbrozkiewicz
380 Followers 745 Following Group Leader @ChariteBerlin, @mpi_nat Alumn👨🏼🔬 @FENSKavliNet Scholar 🔬Translation, Ubiquitin and Ufmylation 🫱🏼 Brain Development
Karthik Varma Gottemu... @Karthik_G_Varma
21 Followers 46 Following PhD student @MPI_Biochem | Interested in Cell biology and biochemistry 🧬🔬
Cyndi Chua @ChuaCyndi2020
441 Followers 3K Following Commissioning Editor, Frontiers in Bioscience-Landmark (ISSN: 2768-6701, SCIE&PubMed Indexed, IF: 3.3), IMR Press Email: [email protected]
Stamatia (Matina) Chr... @ChristakiMatina
24 Followers 197 Following PhD candidate Sheffield Uni | Working on injury-induced inflammation, DUBs and Osteoarthritis in zebrafish. Funded by Versus Arthritis. Ismail Lab
Sjoerd van Wijk @sjoerdjlvanwijk
704 Followers 2K Following Group leader @goetheuni, #ubiquitin, #deubiquitinase, #autophagy, #cellfate and #celldeath #basstrombone (views are own)
Samuel Maiwald @SamuelMaiwald
35 Followers 37 Following PhD student in Schulman lab @MPI_biochem @IMPRS_ML, interested in structural biology and ubiquitin system 🔬
Piotr Karolczak @PiotrKarolczak1
3 Followers 72 Following
Sona Rhee @krisrhee0917
15 Followers 84 Following Protein design, MD simulations, Programming and more
Kun ZANG 坤 @KunZANG2024
50 Followers 433 Following Postdoc at MPIB. Bacterial microcompartment, Phase separation, Protein structure, Rubisco
Verena Kohler @_VerenaKohler
4K Followers 2K Following Assistant professor @VKohler_Lab at Umeå University 🇸🇪; Excited about ageing, protein homeostasis and interorganellar connectivity; Married to @AKohler_Mito,
Kevin Mark @KevinGMark
71 Followers 291 Following Assistant Professor @CellUtsw. Postdoc @berkeleyMCB. PhD Student @UCSF. Determining why proteins are modified with ubiquitin
Journal of Clinical P... @clin_pediatric
668 Followers 4K Following Open access, peer-reviewed medical journal #clinicalpediatrics #childcare Visit us: https://t.co/iBfqq5P4KN…
Charlotte Crowe @CharlCrowe
1K Followers 1K Following Structural biology PDRA @MichaelJFoxOrg / PhD 2024 @AlessioCiulli @UoDCeTPD 🏴🇬🇧/ MChem 2020 @univofstandrews / originally from Strasbourg 🇫🇷
Harsha Garadi Suresh @GaradiSuresh
154 Followers 1K Following Postdoctoral fellow interested in Ubiquitin Proteasome System at Donnelly Centre of University of Toronto. Formerly at University of Heidelberg.
Cristian Prieto-Garci... @CristianPG_mlg
2K Followers 5K Following In @DikicLab @GoetheUni 🇩🇪. #Ubiquitination #Proteostasis #RNA #DNArepair #Cancer 🇪🇸. Past:@UnivCordoba @LaStatale @KingsCollegeLon @unicomplutense @Uni_Wue
Zuzanna Kozicka @zkozicka
664 Followers 508 Following Postdoc @DFCI @HarvardMed @BroadInstitute, previously PhD @LabThoma, Forbes 30U30 Science&Technology 2023, @EdinburghChem graduate (she/her)
Anirbān Dāsgupta @anirban_dg35
218 Followers 343 Following Molecular biologist. Postdoc at UTSW. Interested in epigenetic regulation of gene expression in germ line cells during development and differentiation.
Vasso Makrantoni @Makrantoni_lab
139 Followers 208 Following Lecturer at CIR-IRR, @EdinUni_IRR, University of Edinburgh and @zje_institute. Studying genome instability and antifungal drug resistance in Candida albicans.
Shay Laps @Shay_Laps
585 Followers 3K Following Postdoc, Chou's lab, @Stanford University. Former Israel Academy of Sciences Postdoc fellow @IsraelAcademy
Ian Kelsall @Dr_Ian_Kelsall
476 Followers 435 Following Senior Research Associate @mrcppu, working in the lab of @YKulathu. Interested in ubiquitin, RBR ligases, innate immune signalling and heavy metal 🤘
Emily @seshetheth2798
244 Followers 5K Following See the world on the road, and get to know yourself on the way!
Monte Rosa Therapeuti... @MonteRosaTx
1K Followers 43 Following Monte Rosa Therapeutics is developing next-generation small molecule protein degraders to treat cancer and beyond.
Ferran José Duran @ferran_jose99
80 Followers 211 Following 📍Amposta | Barcelona . 👨🏼🔬 Cancer researcher and PhD candidate at IRB Barcelona 🏂🏼🏓🎹🏳️🌈
Ning Zheng @nzhenguw
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Stephen M Hinshaw @HinshawStephen
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Malte Gersch @MalteGersch
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Priyanka Dahate @PriyankaDahate
93 Followers 290 Following Graduate student at @GlattSebastian @Struc_biol_PL,Kraków & Biotechnology Specialist at @CaptorTherapeu1, Alumna @ccmb_csir, @HydUniv.
Protein-Degraders @ProtDegraders
488 Followers 434 Following All things TPD! Protacs, molecular glues, ligases, proteasome, proximity induced
Mateusz C. Ambrożkie... @MAmbrozkiewicz
380 Followers 745 Following Group Leader @ChariteBerlin, @mpi_nat Alumn👨🏼🔬 @FENSKavliNet Scholar 🔬Translation, Ubiquitin and Ufmylation 🫱🏼 Brain Development
Roman Sarott @RomanSarott
802 Followers 1K Following PI at Max Planck Institute for Medical Research | Chemically Induced Proximity | Gain-of-Function | Stanford Postdoc | PhD 2021 ETH Zürich
Ian Kelsall @Dr_Ian_Kelsall
476 Followers 435 Following Senior Research Associate @mrcppu, working in the lab of @YKulathu. Interested in ubiquitin, RBR ligases, innate immune signalling and heavy metal 🤘
Woong Sub Byun @WoongSubByun
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Radek Nowak @RPNowak
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neomorphinc @neomorphinc
279 Followers 2 Following Solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’.
Centre for Targeted P... @UoDCeTPD
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Karthik Varma Gottemu... @Karthik_G_Varma
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Samuel Maiwald @SamuelMaiwald
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Anirbān Dāsgupta @anirban_dg35
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Vasso Makrantoni @Makrantoni_lab
139 Followers 208 Following Lecturer at CIR-IRR, @EdinUni_IRR, University of Edinburgh and @zje_institute. Studying genome instability and antifungal drug resistance in Candida albicans.
Beata Chrustowicz @BChrustowicz
2 Followers 4 Following
Marcin Kaźmierczak @FantazmAd
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Róża Przanowska @RPrzanowska
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Nitzan Shabek @ShabekLab
2K Followers 2K Following Associate Professor & PI @UCDavis ∙structural biologist⚛︎ ubiquitin system aficionado ✾ signaling & sensing mechanisms in plants🌱🎸dad of 2 🎗️
Agnieszka Konopacka @agako7
222 Followers 992 Following Biology Lead at the ICR Centre for Protein Degradation, Centre for Cancer Drug Discovery. I moved to https://t.co/9KvKbYaF6x
Dawid Zyla @DawidZyla
2K Followers 4K Following Instructor in the @EOSaphire lab at @ljiresearch. ETH Zürich alumnus. In the free time photographer and programmer. #cryoem #python https://t.co/gIPhFDjtlu
Yasin Dagdas @PlantoPhagy
13K Followers 5K Following Professor at Heidelberg University, Centre for Organismal Studies (COS). Interested in Evolutionary Cell Biology, Cellular Quality Control & Autophagy
Christoph Kaiser @CJOKaiser
140 Followers 194 Following Biochemist 🧬 with a crush on cellular 🦠 and structural 🔬 biology
Sara Šepić @sepic_sara
33 Followers 97 Following PhD student at @MPI_Biochem | Interested in biochemistry and structural biology 👩🏼🔬
Jonathan Pruneda @jnpruneda
1K Followers 607 Following Associate Professor at Oregon Health & Science University studying microbial interference in host ubiquitin signaling. Formerly @UWBiochemistry and @MRC_LMB.
Daniel Scott @Daniel_C_Scott
75 Followers 66 Following Scientist @ St Jude Children’s Research Hospital
Susan Shao @sshaolab
1K Followers 383 Following Dissecting molecular mechanisms that regulate protein and cellular homeostasis @HarvardCellBio @HHMINEWS
Klevit Lab @KlevitLab
409 Followers 109 Following @UWBiochemistry. Ubiquitin and small heat-shock proteins. Biochemistry and biophysics. Student-run account. Email Rachel with inquiries.
Arvinas @ArvinasInc
4K Followers 273 Following A revolutionary approach to protein degradation therapeutics. https://t.co/eppnBxVbQi
Amgen 🧪🔬🧬 @Amgen
120K Followers 963 Following Amgen harnesses the best of biology and technology to fight the world’s toughest diseases. 🔗 Guidelines: https://t.co/IROHJVvFrV
Jay Bradner, M.D. @jaybradner
23K Followers 906 Following Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen
LechtenbergLab @LechtenbergLab
771 Followers 387 Following News and updates from the Lechtenberg Lab at WEHI in Melbourne. Interested in Ubiquitin ligases, protein structures, and drug discovery. Views my own.
Ryan Potts @pottslab
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Biotechnologia.pl @Biotechtweetuje
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Eleftheria Papadopoul... @ecpapadopoulou
188 Followers 495 Following @IMPRS_ML PhD student in Schulman lab, @MPI_Biochem 🧪 BIF PhD Fellow 🔬 Interested in Protein Degradation and Molecular Signaling 👩🏻🔬
ChimeraX (bsky: chime... @UCSFChimeraX
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Mun Siong @Mun_Siong_Loke
28 Followers 146 Following
Lukas Teoman Henneber... @LukasHenneberg
96 Followers 159 Following Department of Molecular Machines and Signaling Max Planck Institute of Biochemistry
Alina Thielen @AlinaThielen
65 Followers 95 Following PhD Student in the Schulman Lab interested in E3 ubiquitin ligases in metabolism @MPI_biochem
Keerthiraju E Ravicha... @er_keerthiraju
772 Followers 3K Following Postdoc @SGuettlerLab @ICR_London Alumnus @GlattSebastian Lab @MCB_UJ @JagiellonskiUni @UniofNottingham #DeSci #Urm1 @Urmylation aficionado
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