Monte Rosa Therapeutics, Inc @MonteRosaTx
Monte Rosa Therapeutics is developing next-generation small molecule protein degraders to treat cancer and beyond. Joined May 2020-
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ICYMI: Our team presented data at #AACR24 demonstrating MRT-2359, our GSPT1 #moleculargluedegrader, is active against prostate cancer. These data warrant clinical investigation of MRT-2359 as a single agent or in combination with an AR antagonist. bit.ly/3W9Ats7
Our platform creates a vast opportunity. Great partners who share our vision are key to fully leveraging it. CEO @markus_warmuth on our recently announced collaboration with @Roche, and its potential to advance programs in neurology and oncology: bit.ly/3ZZO6d2
This week, we announced encouraging interim safety, PK/PD and clinical data for MRT-2359 in MYC-driven solid tumors. Monte Rosa CMO @FilipJankuMD on the potential significance of these data for patients living with difficult-to-treat cancers: bit.ly/3QlUzMr
We are honored to partner with @Roche. Their recognition of the potential in #moleculargluedegraders and expertise in developing and commercializing innovative therapies accelerate our mission to deliver transformative treatments to patients. bit.ly/3ZZO6d2
Interim clinical data on MRT-2359 demonstrated favorable tolerability, PK & PD profiles. MRT-2359 has been observed to significantly reduce GSPT1 protein levels in patient tumors and has shown evidence of tumor size reductions. CEO @markus_warmuth comments:
Kicking off Breast Cancer Awareness Month with our very own Ping Pong Tournament Fundraiser for breast cancer research!
Meet our amazing Proteomics Team!
At Monte Rosa, our dedication to improving patients’ lives goes beyond our innovative research; several of our employees participated in Bicycles Battling Cancer both in MA and virtually in Basel. Thank you to all the bike riders for helping to raise money for cancer research.
Tomorrow, in our hometown of Basel, Magnus Walter will be presenting at the Protein Degradation and Targeting Undruggables Congress. Learn about our drug discovery platform in-person, and see our pipeline here: monterosatx.com/queen/
Tomorrow Etienne Donckele will be presenting at the EFMC-ASMC 2023 meeting in Croatia; stop by learn about our cool science!
Happy Birthday to the legendary Freddie Mercury! Through our proprietary QuEEN™ platform (Yes! The name of our QuEEN was inspired by THAT Queen!), we aim to revolutionize the way we treat human diseases the way Freddie revolutionized modern day music.
Feeling gratitude after a day of fun activities at the zoo, where we connected with the amazing families who support Monte Rosa team members outside of work. #Biotech #ItTakesAVillage #Connecting #Gratitude
In advance of #WomensEqualityDay, we recognize those who fought for a better future for women & continue to advocate for equality today. We stand for progress & inclusion as we celebrate the brilliant women scientists at the forefront of biotech research & innovation.
Check it out! A new @AnnualReviews of Pharmacology and Toxicology article on rules that govern rational design of molecular glue degraders. Read the article by @MonteRosaTx, @LabThoma, and Ridgeline: bit.ly/3qNH5yK
Find out about Monte Rosa’s MRT-2359! A highly selective molecular glue degrader of GSPT1 currently in a Phase I clinical trial. Learn more about our novel targeted therapy here: bit.ly/45dPFpx
Today we share out second quarter financial results and business updates. View the full press release here: bit.ly/44TZNnj
We look forward to hearing from our Chief Medical Officer, @FilipJankuMD, during his address, “Developing a Novel Molecular Glue Degrader for MYC-Driven Cancers,” at #ASCO Breakthrough in Japan this week. #ASCOBT23 For more, visit: bit.ly/455ZhCi #oncology
Happy #NationalInternDay to our bright, hard-working Monte Rosa interns! It’s a pleasure to work with the future leaders and #biotech innovators of tomorrow. Hear from our interns about what life is like on the Monte Rosa team:
Dan Nomura @DanNomura
17K Followers 9K Following Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley; Departments of Chemistry and Molecular and Cell BiologyRapé Lab @RapeLab
4K Followers 128 Following molecular mechanisms of cell fate specification in development and disease; molecular glues and induced protein degradation as new therapeutic optionsAdam Gilbert @adammgilbert911
3K Followers 217 Following Executive Director of Medicinal Chemistry at Pfizer. Novel drug discovery strategies #proteindegradation #Covalents #dels #vaccines #PFEcolleagueRadek Nowak @RPNowak
2K Followers 748 Following Professor @UniBonn. Former @DanaFarber @harvardmed | Targeted Protein Degradation | Chemical and Structural Biology | @UniofOxford alumni. Tweets are my own.Vivek Subbiah, MD @VivekSubbiah
34K Followers 2K Following Chief, Early-Phase Drug Development|@SarahCannonDocs #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.Markus Warmuth @markus_warmuth
325 Followers 268 Following passionate drug hunter, avid cyclist, world travelerAndrea Testa @EndriuT
1K Followers 941 Following med chem, protein degradation in BioTech, covalent-curious, gym, knows a lot about classical music 🏳️🌈🎶🏋️ opinions my own, retweets not endorsementThomä Lab @LabThoma
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5K Followers 763 Following The official twitter feed of the European Federation for Medicinal Chemistry and Chemical Biology.Gunning Group @GunningLabUofT
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791 Followers 1K Following Inventing & translating technologies for therapies. ML AI ‘omics & comp biology. Molecular glue for targeted protein degraders. @MonteRosaTx Tweets my ownKymera Therapeutics @KymeraTx
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791 Followers 1K Following Inventing & translating technologies for therapies. ML AI ‘omics & comp biology. Molecular glue for targeted protein degraders. @MonteRosaTx Tweets my ownKaspars Koo @KasparsKoo
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106 Followers 325 Following Senior Research Associate II @ Monte Rosa TherapeuticsNASA's Perseverance M.. @NASAPersevere
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535 Followers 1K Following A wannabe Carolina girl with Indiana roots. @1ABMedia Director of Digital. @BSUCCIM Alum. Lover of good food, sunny skies and anything purple.Awesome session including @MonteRosaTx very own Dr. Owen Wallace, who took a deep dive into molecular glue degraders for challenging targets such as CDK2 and GSPT1 #AACR24
@AnastasiosStat2 The #ESMOTAT24 special session on oncology drug development features insights from: 🎙️ @FilipJankuMD of @MonteRosaTx 🎙️ Yael Gruenbaum-Cohen, DMD, PhD, of @aMoonFund 🎙️ Christophe Le Tourneau, MD, PhD, of @institut_curie
And both presentations available on our website!
Today we share preclinical data that demonstrate preferential activity of our GSPT1-directed MGD in MYC-driven tumor cells. Learn more here: bit.ly/43HpFT2
Mission accomplished #Boston127
Good luck today to our rock star CMO, @FilipJankuMD today as he runs his first Boston Marathon! The entire company will be cheering for you! #BostonMarathon
Wonderful to be working with @befcorreia on AI and protein surfaces for next-gen molecular glue degraders @MonteRosaTx
Very proud that @befcorreia, head of the Lab of Protein Design & Immunoengineering, was selected for this prestigious grant for his project: Computational design of protein components for synthetic #immunology using surface-fingerprints. Congratulations! actu.epfl.ch/news/six-snsf-…
Looking forward to updating on key progress in past year and expected milestones for 2023 @MonteRosaTx. QuEEN rocks!
Don’t miss your chance to hear @markus_warmuth, our CEO speak today at #JPM23! The webcast will be accessible here: ir.monterosatx.com
After quite some pre-take off drama here we go! Looking forward to a productive trip to #JPM23. @MonteRosaTx - nothing’s going to stop us!
@MonteRosaTx Looking forward to presentation by @OleinikovasV on Rhapsody - @MonteRosaTx powerful AI engine for ternary complex models, virtual screening, and generative designs for selective molecular glue degraders.
Don’t stop MRT now! Collaboration w/groundbreaking Prof Sereina Riniker @ETH_en integrating MD into @MonteRosaTx AI/ML Rhapsody engine plus 1st presentation of blazingly fast fAIceit engine fingerprinting protein surfaces for MGD target ID & virtual screening.
Our third quarter financial results and business updates were announced today. View the full press release here: bit.ly/3fZYCyl
Good call out of @MonteRosaTx MRT-2359 phase 1 trial for MYC-addicted tumors. Climbing cancer’s MYC mountain nature.com/articles/d4157…
Timely article on #Myc targeting in #cancer
Climbing cancer’s MYC mountain go.nature.com/3A9tSSm MYC, one of the most commonly dysregulated proteins in cancer, has long seemed ‘undruggable’. Can a clinical-stage cell-penetrating peptide — or preclinical small-molecule inhibitors and degraders — prove otherwise?
A big THANK YOU to the volunteers who joined us last week on the Esplanade from @MonteRosaTx! This great group of @MonteRosaTx employees helped collect and pick up litter from Storrow Lagoon and throughout the park!
I am beyond humbled to be named amongst such a talented and accomplished group of scientists. A big thank you to @MonteRosaTx @CraigMCrews & all the amazing scientists who have taught me something along the way!
They’re finally here! Meet C&EN’s 2021 Talented 12. These early-career scientists are taking on some of the most daunting problems in chemistry: fal.cn/3hBW5 #CENT12
Meet Shanique Borteley Alabi (@AlabiBorteley), the molecular matchmaker designing drugs that break down badly behaving proteins. @MonteRosaTx #CENT12 #ChemTwitter #WomenInSTEM #WomenInScience fal.cn/3hCXv
@MonteRosaTx swag on world tour this summer! GLUEing the world together. Happy August!
Most #TPD companies: we need two linked molecules to degrade the target. @MonteRosaTx : hold my cup…
Fantastic year!
Congrats to all stars @joccastle and Arnaud Osmont on celebrating anniversaries with us in Q2! We are thrilled to call them our own.