Sam Klempner @KlempnerSam
GI medical oncologist focusing on stomach and esophageal cancer research at Massachusetts General Hospital, Harvard Medical School Boston, MA Joined January 2019-
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Nice way to end the week. Pre-print from our team. @arnavmehta3 @JeeyunM @AnMinae, others. Support from @SU2C @AACR. @MGHCancerCenter Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer medrxiv.org/content/10.110…
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Sam Klempner retweeted
A pair of phase 1 trials evaluating antibody–drug conjugates identify potential strategies to treat advanced gastroesophageal #cancers and highlight the rapid expansion of claudin18.2-targeting drug development in solid tumors. News & Views from @KlempnerSam and @sundar__raghav…
Sam Klempner retweeted
Targeting Claudin18.2 beyond monoclonal antibodies like zolbetixumab is arriving! In this article by @KlempnerSam and myself in @NatureMedicine we discuss two promising Claudin18.2 targeting Antibody-Drug Conjugates. nature.com/articles/s4159…
Examining periop Checkpoint inhibitor benefit in gastro-esophageal cancer... sciencedirect.com/science/articl… Led by very talented @josephjzhao and Kennedy Ng. @sundar__raghav
Sam Klempner retweeted
Givastomig, a novel claudin 18.2/4-1BB bispecific antibody, in combination with nivolumab and mFOLFOX in mGEC 🔎Phase I/II 👉ORR 71% 🧐 Interesting activity #ESMOAmbassadors #ESMOGI25 @myESMO
Sam Klempner retweeted
FORTITUDE 101 is a positive Phase 3 study in FGFR2b overexpresssed gastroesophageal cancers! Looking forward to seeing the data and also for FORTITUDE 102 results with combines IO. #FGFR2b amgen.com/newsroom/press….
Sam Klempner retweeted
Enjoying interacting with other speakers and discussants during today’s plenary. Exciting new data was presented.
Sam Klempner retweeted
Attending the #AACR25 session on Innovative Paradigms in Immunotherapy Combos in Gastric Cancer? Read speaker @KlempnerSam's recent @CD_AACR paper: Early Immune Remodeling Steers Clinical Response to Frontline Chemoimmunotherapy in Advanced Gastric Cancer doi.org/10.1158/2159-8…
Adding some spatial omics to HER2+ gastric cancer. Determinants of Response to Sequential Pembrolizumab with Trastuzumab Plus Platinum/5FU in HER2-positive Gastric Cancer: A Phase II Trial aacrjournals.org/clincancerres/… @JeeyunM @AnMinae @arnavmehta3 @CCR_AACR
Proof of principle in KRAS G12C CRC, analogous to EGFR rechallenge in RAS WT Colon cancer. @MGHCancerCenter @JCOPO_ASCO Anti-KRAS G12C + Anti-EGFR Rechallenge in Chemotherapy-Refractory KRAS G12C–Mutated Colorectal Cancer. ascopubs.org/doi/10.1200/PO…
Cool paper from @ShadiEsfahani and team in @ScienceTM @MGHCancerCenter Development of a fibrin-targeted theranostic for gastric cancer | Science Translational Medicine science.org/doi/10.1126/sc…
Sam Klempner retweeted
SCI members @HowardYChang, @mischellab, and others found that blocking #CHK1 activity leads to death of #ecDNA containing tumor cells and tumor regression in mice with a gastric tumor driven by DNA circles. go.nature.com/3Cy7Blr
Targeting DKK1 to Remodel the Tumor Microenvironment and Enhance Immune Checkpoint Blockade Therapy | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…
Adding to the ever growing approaches in GEA. @JCO_ASCO @ASCO. DKN-01 in Combination With Tislelizumab and Chemotherapy as First-Line Therapy in Advanced Gastric or GEJ Adenocarcinoma: DisTinGuish | ascopubs.org/doi/10.1200/JC…
Great to have another option for patients. @KoheiShitara @mdmanishshah @ILSONDavid @FlorianLordick @sara_lonardi1 and many others. FDA Approves Zolbetuximab Plus Chemo for CLDN18.2+ Gastric or GEJ Adenocarcinoma onclive.com/view/fda-appro… via @OncLive
Sam Klempner retweeted
Pleased to share final survival results of two phase 3 of zolbetuximab @NEJM which reinforce zolbetuxumab plus chemo as effective treatment option, though still need better treatment. More agents will be coming for CLDN18.2+ GC @myESMO @OncoAlert #ESMO24 nejm.org/doi/full/10.10…
Pleased to share final survival results of two phase 3 of zolbetuximab @NEJM which reinforce zolbetuxumab plus chemo as effective treatment option, though still need better treatment. More agents will be coming for CLDN18.2+ GC @myESMO @OncoAlert #ESMO24 nejm.org/doi/full/10.10…
Sam Klempner retweeted
Building one of the largest datasets of gastric cancer peritoneal metastases in the world, we unravel new biology of organotropism, the important role of the tumor microenvironment and novel biomarkers. Just published in Gastroenterology! @josephjzhao gastrojournal.org/article/S0016-…
Congratulations to Harsh Singh and @DanaFarber team for getting this data out. CAPOX + Trastuzumab + Bevacizumab in frontline HER2+ gastroesophageal. @NatureComms @JamesClearyMD @DrRonanKelly and others rdcu.be/dQvh4 -- full paper doi.org/10.1038/s41467…
Sam Klempner retweeted
I'd like to call attn. to an outstanding professional development opportunity, the @ASCO Leadership Development Program! I served as a Board liaison mentor & can't overemphasize the impact LDP can have on the career trajectory of participants. Apply here: brnw.ch/21wLj31
Sam Klempner retweeted
I am pleased to inform you that the primary result of JCOG1109 was published in the Lancet today. The neoadjuvant triplet chemotherapy would be the standard care for the locally advanced ESCC. Many thanks to everyone involved. thelancet.com/action/showPdf…
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