Kolmar Lab @KolmarLab

Welcome to the newly elected GBM Board (l.t.r): Harald Kolmar, Blanche Schwappach-Pignataro, ⁦@VolkerHaucke⁩, Klaudia Giehl and Albert Sickmann! Great projects and ideas ahead 👍

Stefania Carrara from the lab of Harald Kolmar @TUDarmstadt is the winner of the Thesis Award🏆 of the @synbiocentre. Congratulations!

Newest #research on a novel type of #multispecific #antibodies is out now in @FrontImmunol, describing trispecific #Tcellengagers with built-in risk mitigation of cytokine release. Read more here: frontiersin.org/articles/10.33…

Remembering the first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories: Marie Skłodowska Curie. Curie was born #OnThisDay in 1867.

Our latest publication in @FrontMolBioSci is out, describing the use of a high-throughput yeast surface display-based screening method for the discovery of novel protein variants with stabilised binding pockets! frontiersin.org/articles/10.33…

New Research: A Generic Strategy to Generate Bifunctional Two-in-One Antibodies by Chicken Immunization: Various formats of bispecific antibodies exist, among them Two-in-One antibodies in which each Fab arm can bind to two different… frontiersin.org/articles/10.33… #immunology

New Research: Streamlining the Transition From Yeast Surface Display of Antibody Fragment Immune Libraries to the Production as IgG Format in Mammalian Cells frontiersin.org/articles/10.33… #bioengineering #biotech

The first chicken-derived two-in-one antibody was generated from immunised chickens without the need for further engineering approaches. Read the full story here: frontiersin.org/articles/10.33… #antibodies #cancertherapy #therapy #twoinone #chickens #bispecifics #yeastdisplay

A new generation of cancer-preventing vaccines could wipe out tumors before they form. fcld.ly/l2sw0w9 #LongReads

PROXIDRUGS amongst the funded #Clusters4Future finalists. Congratulations to all involved! Let’s kick off a new era of drug & technology development in the Rhine Main region. @BMBF_Bund, @goetheuni, @MPIbp, @TUDarmstadt, @UniHeidelberg, #Zukunftscluster, proxidrugs.de

BMFTR @bmftr_bund

5 years ago

PROXIDRUGS amongst the funded #Clusters4Future finalists. Congratulations to all involved! Let’s kick off a new era of drug & technology development in the Rhine Main region. @BMBF_Bund, @goetheuni, @MPIbp, @TUDarmstadt, @UniHeidelberg, #Zukunftscluster, proxidrugs.de

0 5 15 0 1

We report the generation of a chicken-derived biparatopic #commonlightchain #antibody targeting conformational epitopes on domain II and III of #EGFR by using an epitope binning-based #screening approach using #YSD, published in @FrontImmunol Dec 2020: frontiersin.org/articles/10.33…

We recently demonstrated a straightforward #humanization strategy of #chickenderived #antibodies utilizing #YeastSurfaceDisplay and #NextGenerationSequencing, paving the way for avian-derived #mAbs in #therapeutic settings. Read the full article here: lnkd.in/dBSjWsz

New article by @KolmarLab (@TUDarmstadt): Engineering therapeutic antibodies for patient safety: tackling the immunogenicity problem academic.oup.com/peds/peds/arti…

Don't miss today's talk about dextramabs - a novel format for high-drug-load antibody conjugates at #FestofBiologics! #Antibodies #ADCs

Immunogenic reactions against therapeutic antibodies can trigger immune responses in patients. Check out our review article in @ProtEngDesSel where we cover advances to tackle the problem: lnkd.in/durcHtD #antibody #mAbs #immunogenicity #proteinengineering

If you are a corresponding author affiliated with a German university or research institution, you are entitled to publish open access in @NatureComms with fees covered by the German DEAL agreement. Check the list of eligible institutions that are included in the agreement.

#OTD in 1982 laureate James Allison published a paper in the Journal of Immunology identifying the protein structure of the T cell receptor, a previously mysterious ignition switch for immune response. His research led to a new way to treat cancer by using our own immune systems

#Antibodyhitdiscovery by panning experiments were performed for decades using phage display. We recently established a FACS-assisted, yeast surface display-based panning approach. Check out the publication here: lnkd.in/dhYhtFQ #research #antibodies #academicresearch

Welcome to the page of Prof. Harald Kolmar @TUDarmstadt ! Here we will be posting recent publications and other news from our group - check out our website for more information: lnkd.in/eWaCJuF academia #academicresearch #proteinengineering #antibodies #innovation