GFP Clapper @nicholasfwhite
G proteins, SynBio, ML for AAV gene therapy, and now bioinformatics. Boston, MA Joined August 2011-
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True Biopunk
Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In @Nature last week
SOUND ON. You’re hearing the first howl of a dire wolf in over 10,000 years. Meet Romulus and Remus—the world’s first de-extinct animals, born on October 1, 2024. The dire wolf has been extinct for over 10,000 years. These two wolves were brought back from extinction using…
Now do it with biology
Great research on open-source by @Harvard: - $4.15B invested in open-source generates $8.8T of value for companies (aka $1 invested in open-source = $2,000 of value created) - Companies would need to spend 3.5 times more on software than they currently do if OSS did not exist I…
Today we learned that German intelligence had early information—known with a high degree of certainty—that Covid originated in a lab, and the German government deliberately buried it. This isn’t some academic point for historians. The virus’s origin had enormous implications for…
Thanks Michael The static voltage patterns you apply will affect not only membranes but also the microtubules inside the cells, directly and indirectly via membrane changes. In neuronal dendrites and soma the microtubules (each having a polarity) are in mixed polarity,…
Thanks Michael The static voltage patterns you apply will affect not only membranes but also the microtubules inside the cells, directly and indirectly via membrane changes. In neuronal dendrites and soma the microtubules (each having a polarity) are in mixed polarity,…
Dear Science Santa, For Christmas I want: 1. Continuous in-culture sequencing readouts 2. Large scale genome editing, also in culture 3. Enzymatic DNA synthesis at the bench 4. AI in the middle, crunching data, proposing sequences Please, I want to tango with Mother…
we need to be DARPA-maxxing. we need to be developing hagfish slime fibers, we need to be growing 500-meter structures in a vacuum. we need to teach fungi to crave the void and bacteria to dream of stars. we need to be building bio-space-cathedrals with extremophile archdeacons.

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