Hofmann_Lab @LabHofmann
Research group at the University of Cologne Joined July 2020-
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New Parkinson’s disease paper: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by @MalteGersch group @maxplanckpress in @Nature Struct. & Mol. Biol. nature.com/articles/s4159…
Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s4159…
Congratulations, great paper! But what makes you think that this is a CARD and not just any death-fold domain? pyrin and DEDs can also activate caspases and invertebrates use all kinds of death-fold domains for that purpose! I don't think this one really should be called CARD.
Congratulations, great paper! But what makes you think that this is a CARD and not just any death-fold domain? pyrin and DEDs can also activate caspases and invertebrates use all kinds of death-fold domains for that purpose! I don't think this one really should be called CARD.
Great paper, but sorry, this is *not* a CARD domain! It is a 6-helix death fold domain for sure, but there in no evidence provided that it belongs to the CARD subfamily. It might have (convergently?) acquired a similar function as mammalian caspase-associated CARDs. Just saying.
Great paper, but sorry, this is *not* a CARD domain! It is a 6-helix death fold domain for sure, but there in no evidence provided that it belongs to the CARD subfamily. It might have (convergently?) acquired a similar function as mammalian caspase-associated CARDs. Just saying.
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158… https://t.co/2aYW6MW7C5
New Lammers Lab paper out now in @NatureComms!🥳 We reveal high functional diversity within bacterial deac(et)ylases by systematic functional/structural characterization. This is Leonies PhD project and I’m grateful to have contributed to this great work. nature.com/articles/s4146…
Endlessly fascinating and exciting conference with great discussions #EMBOubiquitin24 ! Can’t wait to get back to the lab with some new ideas…
After a long time in the making, our study on bacterial clippases is finally available as a preprint biorxiv.org/content/10.110… These are really fascinating enzymes, for which there will be a ton of applications in studying the #ubiquitin system
Recent reports implicated USP53 mutations in a hereditary liver disorder in children. We got interested in USP53 and its homologue USP54 as phylogenetically they are the most diverse USP DUB family members but according to uniprot are supposed to be catalytically inactive.(2/10)
N4BP1 functions as a dimerization-dependent linear #ubiquitin reader which regulates TNF signalling nature.com/articles/s4142…
Two PhD positions in our research group! If you are interested to study the molecular mechanisms of necroptotic and pyroptotic cell death - and their relationship to plant cell death, do apply!
Two PhD positions in our research group! If you are interested to study the molecular mechanisms of necroptotic and pyroptotic cell death - and their relationship to plant cell death, do apply!
By the way: this project was the brainchild of excellent postdoc Thomas Hermanns, who was also corresponding author! We also acknowlegde support from @C2fBiochemistry and @UniCologne
By the way: this project was the brainchild of excellent postdoc Thomas Hermanns, who was also corresponding author! We also acknowlegde support from @C2fBiochemistry and @UniCologne
Now published: We analyzed the structure of the Burkholderia effector TssM with and without ubiquitin. TssM is a divergent member of the USP-type deubiquinases and can recognize #ubiquitin despite the lack of the 'fingers' domain. life-science-alliance.org/content/7/2/e2…
Congratulations, Tyler & Jonathan, great work!
Congratulations, Tyler & Jonathan, great work!
Out now in NatComms: A Chlamydia-like bacterium with a deubiquitinase repertoire similar to Legionella, but using new DUB classes for the same linkage specificities (e.g. M1, K6). #ubiquitin @UniCologne @C2fBiochemistry doi.org/10.1038/s41467…
Our new manuscript on Burkholderia TssM is on bioRxiv. TssM is an interesting bacterial USP-type dubiquitinase effector, which lacks the so-called 'Fingers' Region used by other USPs for #ubiquitin recognition. Our structures show how TssM does the trick biorxiv.org/content/10.110…
Nice poster!
DUBS 2023 will bring together leading academic researchers in the DUB/ULP area with their counterparts in biotech and pharma to initiate, and advance collaborative research. Register now and join us on 19-21 June: bit.ly/DUBS-2023
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Paola Antonello @Paola632898361
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Max Fottner @MaxFottner
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Nishaant Kumar Palani... @Nishaant_PB
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Felix Randow @FelixRandow
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Marta Campos Alonso @MCamposAlonso
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Harsha Garadi Suresh @HarshaGaradi
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Alexander Goginashvil... @Al_Goginashvili
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Şuayb Üstün 🌱�... @SuayibUestuen
6K Followers 2K Following Professor for Plant Cell Biology @ruhrunibochum #theustunlab, DFG #EmmyNoether alumni, @sfb1101, #ERCStG; 💚s #proteostasis 🇺🇸🇪🇸🇫🇷🇩🇪🇹🇷🇮🇹🇨🇳🏳️🌈
Margot Raffeiner @MargotRaffeiner
251 Followers 211 Following PostDoc @SuayibUestuen Lab @ruhrunibochum; former PhD student @BörnkeLab passioned about molecular biology & plant-pathogen interactions. @ThePlantCell AFE 🌱
Laura Merx @laurame.b... @MerxLaura
464 Followers 613 Following 📍Aachen/Cologne/Germany 🌱plant scientist in the making/ PhD student @agdöhlemann @CEPLAS_1 (she/her) Podcast @krautnah
Tuncay Balkaya 🇹�... @tncyblky
302 Followers 2K Following PhD Candidate of Chemical Biology @UofGlasgow @UofGChem 🔬🧪⚗️🧬🧫 Alumni @unisouthampton @pauedutr
The Postdoctoral @thepostdoctoral
23K Followers 24K Following #postdoc #postdoctoral #postgraduate #fellowship #sciencejobs #postdocjobs #scholar #grants #research #job • Doctors 👉 @SkaDoc_ 👨⚕️👩🏼⚕️
Sourajit Das @ghapikapapi
30 Followers 423 Following Project Fellow @ IHS, Presidency University. Working on the effect of Sepsis on Macrophage
Ethe Portilho @EtheCosta1
224 Followers 3K Following PhD in Physics 👩🔬, interested in Biological Physics, Single-molecule techniques, Cell culture and Physics of Cancer🧬🔬
Ilya Dobrovinsky @DobroIlya
301 Followers 3K Following BSc in Statistics & BA in Psychology from @Uofhaifa Data research analyst at Clalit Health Services "The most resilient wins"
Elliott Lab @Elliott_Lab_Ox
272 Followers 75 Following Latest news from the lab of Paul Elliott. Ubiquitin | Structural biology | Biochemistry. Views our own.
Shiksha Saraogi @ShikshaSaraogi
124 Followers 1K Following (She/Her) High on coffee and science 🧠 | Pursuing my PhD in Friedhoff lab, JLU👩🏻🔬| Previously in @SnippertLab UMC and Medema lab NKI
Yu-Fong Lin @YuFong24854
4 Followers 72 Following
shaghayegh @shaghay43861547
121 Followers 1K Following PhD student in Biochemistry and Biotechnology at @UofGlasgow
jake @mediocre_jake
56 Followers 167 Following 🇲🇾Postdoc WEHI @FelthamLab PhD @BrownLabUNSW #ubiquitin #inflammation #cholesterol 🆕️ 2024 account, past account was deleted - keen to reconnect
Winklhofer Lab @winklhofer_lab
915 Followers 770 Following Dedicated to elucidate mechanisms of #neurodegeneration: #proteostasis, #ubiquitin, #mitochondria
Tabish Iqbal @TabishiqbalSyed
209 Followers 1K Following Postdoctoral Associate at The Rockefeller University, New York 🇺🇸 with Professor Roderick MacKinnon | PhD @DebasisDas_Lab | IISc Bangalore, 🇮🇳
Miratul Muqit @miratul_neuro
992 Followers 300 Following Neurologist. Scientist. Studying PINK1 kinase for as long as anyone can remember.
Walczak Lab @Walczak_Lab
196 Followers 409 Following Studying the functional interplay between cell death, inflammation and (auto-)immunity #inflammation #celldeath #immunity #cancer @uclcancer @BCCologne @CECAD_
Niko Klink @NikolasKlink
109 Followers 193 Following PhD candidate @Gerschlab at the CGC of the @MPImoph and @TU_Dortmund. Fascinated by drug discovery and all things Ubiquitin.
Ian Kelsall @Dr_Ian_Kelsall
476 Followers 435 Following Senior Research Associate @mrcppu, working in the lab of @YKulathu. Interested in ubiquitin, RBR ligases, innate immune signalling and heavy metal 🤘
Trends in Biochemical... @TrendsBiochem
4K Followers 2K Following TIBS is a leading monthly review journal in biochemistry || This account is not monitored, and content || Check us out on Bluesky @cp-trendsbiochem.bsky.social
Monique Mulder @MoniqueMul56559
0 Followers 4 Following
FungLabMeiosis @FungLabMeiosis
359 Followers 2K Following Jennifer Fung's Lab at UCSF studying meiotic chromosome pairing, synapsis, and reproductive toxicity, using yeast genetics, live cell imaging, and computation
Ekaterina Grigoreva @ekatgrigorieva
55 Followers 218 Following MSc MIPT • EIMB RAS • interested in #ubiquitin #proteasome system and #cancer • keen on lomography • tweets are my own opinion 🫧
Yifat Merbl lab @YMerbl
1K Followers 641 Following Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology
Shahab Shah @Shahab19
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Gygi Lab @GygiLab
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Vincenzo DAngiolella @VdangioE3lab
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Dougan Lab @DouganLab
931 Followers 879 Following Regulated proteolysis | N-degron | AAA+ machines | #Proteostasis https://t.co/8P66UdKcLf https://t.co/Wa9filzfVh… views my own
Pei Yee @imPeiYee
151 Followers 572 Following Post-doc at Urbé/Clague lab. Previously @LMCB_UCL Interested in membrane trafficking and ubiquitin biology 🧑🔬
Alga Zuccaro @Team_Zuccaro
1K Followers 335 Following Interested in molecular plant-microbe interactions, symbiosis, cell death, immunity and metabolism, effector biology, microbiota, CEPLAS, views are my own.
Gisela Otten @GiselaOtten1
533 Followers 539 Following Scientist @AmphistaThera and @CambridgeUtdFC director
Sayanika Banerjee @SayanikaIndia
121 Followers 189 Following Exploring the field of protein modifications in mammalian cells as a Postdoc fellow in Hebrew University of Jerusalem
Vishwanath Sivalingam @vishwanath_siva
573 Followers 1K Following Biotech PhD @IITHyderabad. Protein aggregation, amyloid, phase separation, thermodynamics & kinetics. Python 👨💻
Francesco Scavone @scafrancesco1
327 Followers 527 Following Biology @Stanford | Kopito lab | ubiquitin & UBLs, ribosome, protein quality control | Foodbank volunteer | @fscavone.bsky.social | 📷: Sicilian landscape
Pedromics @pedromics
14K Followers 54 Following Scientific cartoons and general scientific nonsense by @pedrovelica
Arno Alpi @ArnoAlpi
276 Followers 212 Following Cell biologist with keen interest in biochemistry and structural biology. Exploring ubiquitin biology. Love mountaineering
Dikic lab @DikicLab
1K Followers 81 Following Research group of @iDikic2 at @IBC2_GU. ubiquitination, autophagy, host-pathogen interactions
Michael Lazarou @LazarouLab
1K Followers 604 Following Working toward understanding how we can keep our mitochondria fit and healthy. Co-founder: Automera Also here: @lazaroulab.bsky.social
Isabel Saur @IzzySaur
3K Followers 1K Following These days you find me on bluesky @izzysaurlab.bsky.social MPMI @ University of Cologne. Immunity, AVR, receptors, mildews, cereals .....
Yifat Merbl lab @YMerbl
1K Followers 641 Following Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology
Margot Raffeiner @MargotRaffeiner
251 Followers 211 Following PostDoc @SuayibUestuen Lab @ruhrunibochum; former PhD student @BörnkeLab passioned about molecular biology & plant-pathogen interactions. @ThePlantCell AFE 🌱
Shalini Agarwal @Agarwal_Shal04
472 Followers 749 Following PostDoc @MRCPPU Interested in Mitochondrial Quality Control in ALS/MND
Şuayb Üstün 🌱�... @SuayibUestuen
6K Followers 2K Following Professor for Plant Cell Biology @ruhrunibochum #theustunlab, DFG #EmmyNoether alumni, @sfb1101, #ERCStG; 💚s #proteostasis 🇺🇸🇪🇸🇫🇷🇩🇪🇹🇷🇮🇹🇨🇳🏳️🌈
Max Fottner @MaxFottner
271 Followers 462 Following Postdoc in the @klanglab at ETH Zurich. Trying to shed light on the ubiquitin system using chemical biology.
Marta Campos Alonso @MCamposAlonso
45 Followers 91 Following PhD student focused on deubiquitinases. Enthusiast of nature and sports.
Laura Merx @laurame.b... @MerxLaura
464 Followers 613 Following 📍Aachen/Cologne/Germany 🌱plant scientist in the making/ PhD student @agdöhlemann @CEPLAS_1 (she/her) Podcast @krautnah
Mukherjee Lab @Mukherjee_Lab
477 Followers 165 Following Our lab is using Legionella pneumophila as a tool to gain insights into basic mammalian cell-biological processes. @UCSF
Rudel Lab @lab_rudel
188 Followers 18 Following Our main research focus is on host-pathogen interactions and pathogenicity mechanisms. /Impressum: https://t.co/42JMySKnnQ @Uni_Wue
Vera Kozjak-Pavlovic @Kozjak_Lab
211 Followers 307 Following Professor @Uni_WUE, Pathogenic bacteria and mitochondria/ Neisseria & Chlamydiales. I just realized I could be more creative with this description. Too late.
Kris Gevaert @KrisGevaert_VIB
1K Followers 549 Following proteomics, N-terminal proteoforms, UGent, senior full professor and department head, VIB principal investigator, VIB-CMB associate director
Fabien Thery @FabienThery1
194 Followers 520 Following Interests in biochemistry, host-bacteria interactions, mass spectrometry-based Proteomics and immunopeptidomics for the design of antibacterial vaccines.
Vega Shah @dr_alphalyrae
18K Followers 4K Following AI for Life Sciences & Healthcare @NVIDIA | trained as a scientist from @JGI, @UW, @UCBerkeley | building global community @TechBi0 | views are all mine
Machine learning for ... @ml4proteins
8K Followers 124 Following Seminar series on machine learning for protein engineering. Details for seminars and slack are on our website. DM us if you're interested in presenting!
Yu-Fong Lin @YuFong24854
4 Followers 72 Following
Winklhofer Lab @winklhofer_lab
915 Followers 770 Following Dedicated to elucidate mechanisms of #neurodegeneration: #proteostasis, #ubiquitin, #mitochondria
Rahul Samant @SamantLab
2K Followers 2K Following Group Leader @BabrahamInst. He/him. All things #ubiquitin #proteostasis #proteomics #ageing #senescence. Spend too much on food & wine. Opinions mine, all mine!
Marcin J. Suskiewicz @MSuskiewicz
1K Followers 4K Following Structural biologist and biochemist. CNRS researcher at CBM Orléans. Interested in protein modifications & interactions. Also husband, dad of 2, friend, ☧.
Loges Krshnan @LogesK
408 Followers 1K Following Molecular biologist interested in how proteins are made and maintained in cells. Now @mrcppu, previously @unimelb @NTU_LKCmedicine @UniofOxford. 🇲🇾🌈👨🏾🔬🌏
Walczak Lab @Walczak_Lab
196 Followers 409 Following Studying the functional interplay between cell death, inflammation and (auto-)immunity #inflammation #celldeath #immunity #cancer @uclcancer @BCCologne @CECAD_
Niko Klink @NikolasKlink
109 Followers 193 Following PhD candidate @Gerschlab at the CGC of the @MPImoph and @TU_Dortmund. Fascinated by drug discovery and all things Ubiquitin.
Miratul Muqit @miratul_neuro
992 Followers 300 Following Neurologist. Scientist. Studying PINK1 kinase for as long as anyone can remember.
Ian Kelsall @Dr_Ian_Kelsall
476 Followers 435 Following Senior Research Associate @mrcppu, working in the lab of @YKulathu. Interested in ubiquitin, RBR ligases, innate immune signalling and heavy metal 🤘
Matt McFarland @emseefarlandee
262 Followers 797 Following Postdoc @MRCPPU with @YKulathu. Bright Clubber. Runner. Massive nerd. Views own, and probably rubbish. Big fan of soup.
Tyler Franklin @tylergfranklin
119 Followers 151 Following Postdoctoral scholar studying ubiquitin signalling in the Pruneda lab at OHSU. Previous @Lugerlab undergrad and @NREL tech.
hw1o9 @hw1o9
3K Followers 3K Following
sciebo - www.hochschu... @sciebo
757 Followers 32 Following ⚠️ Dieser Account ist stillgelegt. #eXit #ByeByeX #QuitX sciebo ist ein Cloud-Speicherdienst von und für Hochschulen in NRW.
Becky Lamason @lamasonlab
1K Followers 516 Following Associate professor at MIT studying host-pathogen interactions
Justin Maire @Justin_Maire
234 Followers 97 Following
Dr. Joanne Hildebrand @jo_hildebrand
311 Followers 347 Following The scientist, not the guy on TV. She/her, views my own
Ole Schmöker @oleschmoeker
84 Followers 164 Following PhD researcher in #structbio/#biochem @ Lammers lab @uni_greifswald interested in ubiquitination/lysine acetylation in bacterial infection. part of @RTG2719_PRO
Elliott Lab @Elliott_Lab_Ox
272 Followers 75 Following Latest news from the lab of Paul Elliott. Ubiquitin | Structural biology | Biochemistry. Views our own.
UBIMOTIF @ubimotif
224 Followers 42 Following UBIMOTIF is a European training network with outstanding scientists at the forefront of SLiM and ubiquitin biology funded by @EUcommission and @MSCActionsTrends for United States
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