Mueller Lab @LabMueller
Birmingham, England Joined June 2018-
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3 days of outstanding talks from @IcgsUob PhD students, well done everyone. Winners of best 3rd year talk and receiving conference travel funds are Tom Starkey and Paige White from @beggs_lab @ferencmueller labs. congratulations to you both 🎉
Please check out our paper in Developmental Cell (bit.ly/2Pu7xdP) on the 2 phases of chromatin accessibility and genome activation in zebrafish PGCs. By @FabioDorazio with @PiotrBalwierz @Circe777 and contributions @splendidsunjane B Cairns @Vaquerizas @BorisLenhard labs
We started the this project with the ambitious goal of studying how the germ line links generations at the beginning of life. Now I like to think that goal is achieved and we better understand how the germ line forms. Great thanks to all co-authors
We started the this project with the ambitious goal of studying how the germ line links generations at the beginning of life. Now I like to think that goal is achieved and we better understand how the germ line forms. Great thanks to all co-authors
@the_Node here is the single figure abstract
Learn more about the regulation of transcription in primordial cells in the lab's latest preprint #BSDBGenSoc2020 biorxiv.org/content/10.110…
Our ms on regulation of transcription in primordial germ cells is out in BioRxiv bit.ly/2tTXmoi led by @FabioDorazio @PiotrBalwierz with @vaquerizasjm @BorisLenhard B. Cairns lab #ZencodeITN #pgc #generegulation. See related study bit.ly/2sogBFX by @KettingLab
Our new work on distinct transcription initiation regulation by cell cycle dynamics @zebrafish in bioRxiv: tinyurl.com/weaplrd by @j_wragg_bham with L Roos, @ncvetesic @BorisLenhard lab #generegulation
Our paper with @ChiragNepal and @BorisLenhard, @carninci, Peers and Andersen labs is out in Nat Comm Go.nature.com/2QR1gHf. Novel class of core promoters: dual initiation promoters facilitate distinct posttranscriptional processing of transcripts in fish, fly and humans.
Our fish have all left @sangerinstitute and are now at @CamBioCampus. We humans join them in 20 days. If you're interested in chromatin and want to come too then you've got about 24 hours to apply for jobs.cam.ac.uk/job/22839/
All this in 2 months.... 9/10 women PIs. #icgs @unibirm_MDS #genomebiology @Morris_Lab_DSBs @AgaGambus @ColemanLab @LabMueller @EvaPetermann @UoBWomensNet @LabMonteiro @HPVsupergroup
Describing a nuclear transcription compartment associated with the earliest waves of genomic activation: Proud to have our paper published online at @NatureComms . Thanks to all those involved! nature.com/articles/s4146…
Great to see the C1 single cell CAGE finally out. CAGE allows profiling capped mRNA expression and simultaneous single-base resolution mapping of their promoters, as well as promoters of lncRNAs and enhancer RNAs. This work... nature.com/articles/s4146…
1/ Excited to announce our latest work looking at the role of transposable elements in regulating 3D chromatin during early mammalian development, out now in @biorxivpreprint @vaquerizas_lab #3DGenome #transposons #early_mouse_development biorxiv.org/content/early/…
Just over 2 weeks to go until the application deadline of 20 January for the 2019 intake.
Just over 2 weeks to go until the application deadline of 20 January for the 2019 intake.
News & Views: A study in Nature reports that in the nuclei of mouse olfactory sensory neurons, certain regions of multiple chromosomes assemble in a structure that controls the expression of the full repertoire of olfactory-receptor genes in the nose. go.nature.com/2SP9gHl
Happy to share our latest pre-print! Great work @DobrzyckiTomasz, Monika K and collaborators! A zebrafish model for MonoMAC syndrome identifies an earlier role for gata2 in haemogenic endothelium programming and generation of haematopoietic stem cells biorxiv.org/content/early/…
"Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs" published by Lagha lab rdcu.be/bdl9H
Excited to share our preprint on human islet 3D genome maps Thx to many... @irene_miguelesc @sbguarch Ines Cebola @geek_y J Ponsa D Rolando @Peter_Fraser1 @BiolaMJavierre @mamartirenom @iosonoirene T Hansen @Inga_genetics @josep_mercader L Pasquali et al biorxiv.org/content/early/…
Congrats, Ada!
Great talk by @ferencmueller at the 3rd Danube Conference on Epigenetics this week!

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