Tinnefeld Lab @LabTinnefeld
Our NanoBioSciences lab @LMU_Muenchen brings together a unique combination of #molecularbiology, #physicalchemistry, #biophysics and #nanophotonics. tinnefeld.cup.uni-muenchen.de Munich, Germany Joined April 2020-
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🎉 Großer Erfolg in der Exzellenzstrategie für die #LMU: Alle sieben beantragten Exzellenzcluster haben sich im Begutachtungsverfahren durchgesetzt und werden ab 2026 für sieben Jahre gefördert! Ein herausragendes Ergebnis! 🎉lmu.de/de/newsroom/ne…
And read the News & Views from @PallavKosuri on this work, here: nature.com/articles/s4159…
Awardees of Römer Prize 2024 presenting their theses: Jakob (Master), Martina (PhD) and @lgrabenhorst_ (PhD). Congrats to all of you!🥳👏 cup.lmu.de/en/latest-news…
Excited to share it now in its final form in @NatureNano: our approach to decouple sensing from signal output to build modular and tunable DNA origami sensors with high FRET contrast: rdcu.be/dZqUd 💡🧬🔬
Thanks to all who contributed to this work, especially the dream team of Michi and @GBruggenthies 🧑🔬👨🔬, @LabTinnefeld , and @Amelie_HJ for wonderful collaboration and so many nice discussions! 🤓
To showcase the potential for correlative studies, we also combine the sensor with DNA-PAINT superresolution imaging to simultaneously probe coating, structural integrity, as well as preserved addressability of DNA nanostructures
Using an environment-senstive dye we non-invasivelly probe the coating of DNA origami nanostructures by either cationic polymer or silica, study the kinetics and reversibility of the coating processes, as well as the stability of coated structures under degrading conditions
Check out our most recent work on monitoring the protective coating of single DNA origami nanostructures with a molecular fluorescence lifetime sensor: biorxiv.org/content/10.110…

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