MatteviLab @MatteviLab

Structural Biology group in the heart of Pavia, Italy. We love enzymes, occasionally membrane proteins, structure-based drug discovery and biocatalysis. www-9.unipv.it/biocry/index.p… Pavia, Italy Joined November 2022

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MatteviLab @MatteviLab

3 weeks ago

With Christoph Gorgulla, StJude and Haribabu Arthanari, Harvard. AdaptiveFlow screens ultra large libraries of 70 billion compounds. We discover #coenzymeQ inhibitors of #ferroptosis suppressor protein #FSP1 validated experimentally and crystal structures biorxiv.org/content/10.110…

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MatteviLab @MatteviLab

4 weeks ago

Delighted to see our ERC project featured on @CORDIS_EU as the project of the month. We are keen on understanding the architecture of metabolism: Unlocking the secrets to enzymes, the catalysts of life | News | CORDIS | European Commission cordis.europa.eu/article/id/460…

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Valentin F. Cracan @VFCracan

3 months ago

pubs.acs.org/doi/10.1021/ac…

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Dianzhuo(John) Wang @DianzhuoWang

3 months ago

🙌 Co-authors: @DianzhuoWang , @AndreaGottinger , Jio Jeong, Callum R. Nicoll, @liu_junlang , @T_Kadava, Domiziana Cecchini, Marco Malatesta, Albert J.R. Heck, @MatteviLab , @ShakhnovichLab Questions welcome! DM or reply 👇 #biophysics #metabolism #syntheticbiology

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Dianzhuo(John) Wang @DianzhuoWang

3 months ago

📄 Read the full preprint: doi.org/10.1101/2025.0… Big thanks to our teams at @HarvardCCB, @unipavia , and @UUBeta!

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Dianzhuo(John) Wang @DianzhuoWang

3 months ago

🧵1/ Excited to share our new preprint! “Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesis via Substrate Channeling” A collaboration between @ShakhnovichLab and @MatteviLab Read on bioRxiv: biorxiv.org/content/10.110…

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Martina_L_Contente @ML_Contente

5 months ago

💥Proud to share our piece on the pioneering women who shaped the field of #biocatalysis and inspired our journeys. Grateful to @anabel_gzl @Caroline_E_Paul and @SandySchmidt24 for joining me in dedicating it to the nextgen women in science and to my little doughter Camilla♥️

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MatteviLab @MatteviLab

5 months ago

Happy to share with Brian Liau our work in @NatureComms studying the mechanism of covalent ‘formylators’ that target the histone demethylase LSD1. Our findings offer a glimpse on a new mechanism for drug resistance. rdcu.be/ef9VT

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MatteviLab @MatteviLab

6 months ago

Interested in shutting down two powerful enzymatic sources of ROS? Check out our latest work in J Med Chem on dual NOX2/MAOB covalent inhibitors. In microglia models, it reduces ROS production and proinflammatory cytokines. #ROS #oxidativestress pubs.acs.org/doi/full/10.10…

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Ligia O. Martins @lom_martin

6 months ago

📣 There is a new PhD training network that combines computational & experimental enzyme engineering lead by @itqbnova to address materials recicability and contribute to a circular economy. Spread the word 🙌

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MatteviLab @MatteviLab

6 months ago

Excited to share our latest work with the Fraaije (Groningen U) & Ram (Leiden U) groups on sorbicillinoid natural products in ACS Chem Bio! CRISPR-powered expression in A. niger boosts protein yields, and crystal structures reveal key catalytic mechanisms. pubs.acs.org/doi/10.1021/ac…

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rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels

6 months ago

George M. Sheldrick (1942-2025) ecanews.org/blog/2025/02/2…

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Harvard Chemistry @HarvardCCB

7 months ago

Writeup of new @Nature articles from the @brian_b_liau Lab #chemtwitter news.harvard.edu/gazette/story/…

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MatteviLab @MatteviLab

7 months ago

Wonderful work and so happy for being part of it.

Brian Liau @brian_b_liau

7 months ago

Wonderful work and so happy for being part of it.

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Zhipeng A. Wang @ZhipengA

8 months ago

Hiring! After six months in Miami, I’m excited to officially launch this new journey. Seeking motivated postdocs to join our lab at the UMiami Miller School of Medicine, exploring protein epigenetics and chemical proteomics in cancer and aging. zawanglab.com/publications

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rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels

8 months ago

After a remarkable 300 columns, @dsgoodsell has retired from the Molecule of the Month. We are so grateful for his service! @janetiwasa will continue the series, beginning with January's article on Assembly Line Polyketide Synthases Details: cdn.rcsb.org/rcsb-pdb/gener…

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MatteviLab @MatteviLab

8 months ago

To be or not to be an oxidase? 🧪 Dive into our latest exploration of this classic enzymatic conundrum, now published in @ACSCatalysis: 10.1021/acscatal.4c05944. Grateful for the fantastic collaboration with @lab_colombo, @dirktischler, and @fraaije1!

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William L. Jorgensen @JorgensenWL

8 months ago

It is very sad to learn that Martin Karplus passed away on Dec 28 at age 94. He was a scholar and pioneering chemical physicist with great contributions in many areas including molecular dynamics. We interacted many times starting from my graduate time at Harvard. His legacy is…

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B-LigZymes RISE H2020 @bligzymes

8 months ago

It ended:) But after completing 180 out of the 211 staff international & intersectoral exchanges planned! and forty researchers at different career stages gained/transfer their skills, developed new R&I, some boosted their careers. More solid networks emerged. Thank you all!