@1goodtern One by one, all the people in my life who gently suggested Covid didn’t disable me & won’t disable them, are now disabled. All my “We have to live our lives” people now have cancer, cardiovascular complications, seizures, diabetes, autoimmune disorders, etc. in their 20s-50s.
Persistent immune misfiring and subsequent irregular metabolic cues in ME/LC inhibit autophagy by activating mTOR which inactivates ATG13 which and induces IL-6 and RANTES… which demyelinates nerves in the muscles and spinal cord contributing to fatigue, possibly PEM.
Taking L-Theanine at night, and not eating 2 hours before sleeping has significantly improved my sleep metrics in a couple of weeks. Before I would typically get around an hour of REM, my hrv was lower, and my resting heart rate was higher.
Recently, I've been impressed at how dramatically L-Theanine has increased my REM sleep. Last night I got almost an hour more of REM than I usually do. I believe it's also decreasing my daytime anxiety baseline by increasing GABA levels.
PMC COVID-19 Forecasting Model, Dec 2, 2024
In a best-case scenario, we could see 700,000 daily infections/day near the peak. Worst-case, probably 1.4 million. These are all very bad levels of transmission, but nowhere near last winter, where we peaked near 2 million daily…
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The pandemic ends when infections end, not when your attention span ends.
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