Rick Bright @RickABright
Practical, Innovative, Hyper-focused on saving lives. Immunologist, Virologist, Pandemic Nemesis. Posts are mine. Washington, DC Joined January 2017-
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VERY grateful to see more data from @USDA. 🙏 @angie_rasmussen has done great job of walking thru the report. H/t Angie. 🙏 It's complex, w/ many outstanding questions. Best way to get answers is to accelerate investigation, share data, & collaborate for faster insight.
VERY grateful to see more data from @USDA. 🙏 @angie_rasmussen has done great job of walking thru the report. H/t Angie. 🙏 It's complex, w/ many outstanding questions. Best way to get answers is to accelerate investigation, share data, & collaborate for faster insight.
People most at risk to become infected with highly pathogenic avian influenza virus H5N1 are dairy workers. 51 % of labor on dairy farms in USA is by immigants without permanent legal status, with all uncertainties that entails. #vogelgriep nmpf.org/issues/labor-r…
“Out of caution and given how widespread H5N1 is in the USA, testing of cows in the UK would make sense and isn’t that costly – it’s short-sighted of the government and I’m surprised it’s not happening.” telegraph.co.uk/global-health/…
Continued progress being made by @US_FDA on milk safety testing. Would be even more assuring if they could share protocols & data soon. Same caveats, data are preliminary w/ many critical experiments outstanding. And, it’s all a snapshot in time. As outbreak spreads to more…
It’s very important to test at the source. It seems @USDA is trying to gain access to farms & animals to study outbreak and efforts are being stymied. Important to quickly study extent of the outbreak, and the origin. Without knowing where/how this started, little can stop it…
It’s very important to test at the source. It seems @USDA is trying to gain access to farms & animals to study outbreak and efforts are being stymied. Important to quickly study extent of the outbreak, and the origin. Without knowing where/how this started, little can stop it…
This is unfolding in interesting way as more data slowly coming out from @USDA. Imp to note this likely originated from a single/limited infection, within a confined area. Meaning also, this could’ve been detected, contained, halted in a single area. It was likely spread…
This is unfolding in interesting way as more data slowly coming out from @USDA. Imp to note this likely originated from a single/limited infection, within a confined area. Meaning also, this could’ve been detected, contained, halted in a single area. It was likely spread…
There's never good time to stop collecting & reporting data. But in midst of nationwide outbreak of highly pathogenic H5N1 avian influenza in food supply animals and other mammals, all in close/constant interface with humans, seems to be one of the worst times to turn off the…
There's never good time to stop collecting & reporting data. But in midst of nationwide outbreak of highly pathogenic H5N1 avian influenza in food supply animals and other mammals, all in close/constant interface with humans, seems to be one of the worst times to turn off the…
Apparently, public health officials are struggling to gain access to farms to conduct a thorough epi study. They' haven't started critically imp antibodies studies among workers at farms or milk processing facilities, nor have they started these critical studies for cows/farm…
Apparently, public health officials are struggling to gain access to farms to conduct a thorough epi study. They' haven't started critically imp antibodies studies among workers at farms or milk processing facilities, nor have they started these critical studies for cows/farm…
Look out for your kittens, folks. Autopsies on US farmyard cats thought to have caught H5N1 from infected milk found half of them died with lesions on their hearts, brains, eyes, and lungs. telegraph.co.uk/global-health/…
“The concentration of the H5 gene in the samples was nearly as high as the concentration of the influenza A viruses overall, suggesting that a large fraction of the viruses in the samples were H5N1.” cnn.com/2024/04/30/hea…
As an advisor to @cure345 Xchange challenge, I know first hand that @EveryCure AI-powered platform could change the way we approach repurposing of already approved drugs to find potential new treatments & cures for millions of patients who suffer from the most debilitating…
As an advisor to @cure345 Xchange challenge, I know first hand that @EveryCure AI-powered platform could change the way we approach repurposing of already approved drugs to find potential new treatments & cures for millions of patients who suffer from the most debilitating…
Interesting #H5N1 preprint on wastewater just dropped. medrxiv.org/content/10.110… Three take-homes: 1. Can H5 be detected in wastewater? Yes, one company (@Verily) now has an assay. It's 100% specific. Huge first step.
It’s not only they’re 2 shot vaccines, they’re made in eggs & cells w/ many limitations due to yield & immunogenicity. They will require additional of adjuvant and will take many months for supply ramp up. Vietnam waited 2 years for flu vaccine in the 2009 H1N1 pandemic. We…
It’s not only they’re 2 shot vaccines, they’re made in eggs & cells w/ many limitations due to yield & immunogenicity. They will require additional of adjuvant and will take many months for supply ramp up. Vietnam waited 2 years for flu vaccine in the 2009 H1N1 pandemic. We…
Excellent 🧵 by @celinegounder w/ critical data & outstanding questions. Great to follow her for updates.
Excellent 🧵 by @celinegounder w/ critical data & outstanding questions. Great to follow her for updates.
Very concerning again. I don’t think stockpile of oseltamivir/tamiflu is going to get us far in an H5N1 influenza outbreak in people. It’s highly susceptible to virus resistance w/ a single mutation & it’s modestly effective if given within first 1-2 days of infection. Without…
Very concerning again. I don’t think stockpile of oseltamivir/tamiflu is going to get us far in an H5N1 influenza outbreak in people. It’s highly susceptible to virus resistance w/ a single mutation & it’s modestly effective if given within first 1-2 days of infection. Without…
4/ What's concerning is that the PB2 E627K mutation appeared quickly: 🔸the virus mutated in this individual or 🔸there was evolutionary pressure selecting for this mutation from among sub-dominant species.
This is exactly what I’d expect from high path avian influenza H5N1 in many mammals. It’s a deadly virus. Any attempts to minimize the threat of this virus are irresponsible. This virus can change easily, can spread swiftly, and cause great harm. There has never been such…
This is exactly what I’d expect from high path avian influenza H5N1 in many mammals. It’s a deadly virus. Any attempts to minimize the threat of this virus are irresponsible. This virus can change easily, can spread swiftly, and cause great harm. There has never been such…
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4K Followers 3K Following Investigating power & politics in the capital of global health. Reported, Curated & Published by @pretpat Sign up! https://t.co/8B5KQatx2s Support: https://t.co/eGC65rdSEoJosh Nathan-Kazis @joshnathankazis
7K Followers 975 Following Covering healthcare companies for Barron's. Opinions my own. Subscribe for updates: https://t.co/CKk7YBnxNMChris Hendel @chrishendel
4K Followers 4K Following Adj Research Instr of Med @KECKSchool_USC; COVID research & projects, @ProPublica; fmr chief med researcher @ConsumerReports 1989-2018; & @chrishendel elsewhereThis information is essential to both understand how cows are transmitting the virus & to plan experiments testing transmission hypotheses. That will be crucial for stopping spread in cattle as well as preventing further transmission across species to humans, birds, cats, etc.
Well, it appears that USDA has finally taken more steps toward sharing more of the H5N1 cattle data. Really grateful to this research team for sharing this, though I hope they weren’t holding on to the data solely to ensure they published first. biorxiv.org/content/10.110…
@angie_rasmussen Agree, this is a good start..."a reassortment event in wild bird populations preceded a single wild bird-to-cattle transmission episode. The movement of asymptomatic cattle has likely played a role in the spread of HPAI within the United States dairy herd..."
@RickABright @USDA Is there antiviral resistance spillover from humans back to cows? These workers were surely not absent from work for 10 days. "Some of the workers who fell ill sought treatment and were offered oseltamivir.." time.com/6973562/texas-…
@DrEricDing @CDCDirector @CDCgov We need an organization that actually controls disease, not disease narratives.😡
I hear that. Oat milk is a pleasant surprise though. 👍🏿
@AcrossTheMersey Still holding. Experimenting with oat / nut milks for now. Hard to find these w/o lists of chemicals. Looking for 2-3 ingred options: nut+water+sometimes salt (for oat milk). Many popular brands seem loaded other chems/sugars.
Important updates regarding USDA's recent testing of beef for H5N1. Ground beef sold at retail in affected states tests negative; tests of muscle tissue on-going. aphis.usda.gov/livestock-poul…
This is good. Increased transparency and proactive moves like this are important for bolstering consumer and public confidence. bovinevetonline.com/news/industry/…
People most at risk to become infected with highly pathogenic avian influenza virus H5N1 are dairy workers. 51 % of labor on dairy farms in USA is by immigants without permanent legal status, with all uncertainties that entails. #vogelgriep nmpf.org/issues/labor-r…
FDA finds no live H5N1 avian flu virus in sour cream or cottage cheese, will assess raw milk The FDA will test pooled raw milk to give the agency a better picture of the viral load before pasteurization. ow.ly/4a2v50Ru9Ti
“Out of caution and given how widespread H5N1 is in the USA, testing of cows in the UK would make sense and isn’t that costly – it’s short-sighted of the government and I’m surprised it’s not happening.” telegraph.co.uk/global-health/…
Dr Bright is damn right. Letting a CMS decision made at the start of pandemic hold is a total failure that defies any reasoning and represents a total dereliction of duty to protect public health. Even if H5N1 wasn’t such a concern I would say the same. Inexcusable @CDCDirector😡
There's never good time to stop collecting & reporting data. But in midst of nationwide outbreak of highly pathogenic H5N1 avian influenza in food supply animals and other mammals, all in close/constant interface with humans, seems to be one of the worst times to turn off the…
@RajlabN @USDA_APHIS Good initial step to test beef in the US food supply, but *note* @USDA_APHIS has only tested 30 samples of ground beef in states that have had dairy herds test +ive for #H5N1. This really isn't a great way to test if beef cattle are being/ have been infected with H5N1 #HPAI
@Alexander_Tin @USDA A number of herds involved in “initial spillover” Everywhere all at once in Amarillo? Fire related? Simply Amarillo related? Ottumwa March-May 2023? Seems odd to have jumped in so many herds all at once unless waterfowl bird carcasses burning causes air-smoke disbursal of H5?
From @USDA's Rosemary Sifford today H5N1 spillover from wild birds in Texas to dairy cattle now believed to have infected "a number of herds" in area "animals from those herds moving to other herds in other states were the initial movement of the virus" tinalexander.github.io/notes/2024/05#…
When does @USDA think H5N1 HPAI first spilled over from wild birds into cattle? From presentation to @ASTHO today: "Independent analysis by @USDA_ARS supports a single introduction, currently estimated in early February 2024" tinalexander.github.io/notes/2024/04#…
We now enter the blackout phase of epidemiology: There will be patients, but their numbers and whereabouts will be unknown, with no central databases. Swell.
Today is the last day U.S. hospitals will be required to report COVID admissions, capacity, or occupancy data to the federal government. This will make it even more difficult to track the state of the ongoing COVID pandemic, as well as monitor potential pandemics like bird flu.
“The reluctance of workers and farmers to allow testing is “greatly hampering” understanding of how the virus spreads, how large the outbreak is now and how quickly it may grow”
This Texas veterinarian helped crack the mystery of bird flu in cows apnews.com/article/bird-f…
Look out for your kittens, folks. Autopsies on US farmyard cats thought to have caught H5N1 from infected milk found half of them died with lesions on their hearts, brains, eyes, and lungs. telegraph.co.uk/global-health/…
“The concentration of the H5 gene in the samples was nearly as high as the concentration of the influenza A viruses overall, suggesting that a large fraction of the viruses in the samples were H5N1.” cnn.com/2024/04/30/hea…
“When I see people talking about milk, milk, milk, I think maybe we’ve lost the plot a little bit,” theatlantic.com/health/archive…
@MoreauGabarain @RickABright @PhyllisG123 @Rebecca41686810 @HelenBranswell This has been my question for a while now. If the efficacy of pasteurization is still an open question what does that mean for other dairy products. Butter, Cheese, Yoghurt etc.