Mark Borris Aldonza (@precursorcell.bsky.social🦋) @PrecursorCell
@eLife ambassador. Researcher @KAISTPR. PhD cand @SeoulNatlUni. Passionate scientist working on animal genomes🐕, cancer 👾, stem cells🧫, drug off-targets💊 sites.google.com/view/borrisald… Daejeon, Republic of Korea Joined October 2014-
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Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
🧵1/ We @tahoe_ai just published a new post on the Tahoe blog—a story of how we used Tahoe-100M, the world’s largest drug-perturbed single-cell dataset, to find compounds that upregulate MHC-I and make tumors more visible to the immune system. Here’s how 🧬🔍👇
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Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations hubs.li/Q03njKxr0 Collection highlight from Cell Genomics
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
The off-target effects of any CRISPR-based genome editor are identified with Tracking-seq go.nature.com/45QH0L5 rdcu.be/em32d
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Improving gene isoform quantification with miniQuant nature.com/articles/s4158… #journals #feedly
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. nature.com/articles/s4158… out now in @Nature with @henri_niskanen @dhnisz & team.
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
BioPortal: an open community resource for sharing, searching, and utilizing biomedical ontologies. #Ontology #BiomedicalOntologies #BioPortal @NAR_Open academic.oup.com/nar/advance-ar…
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
An atlas of transcription factor-driven gene programs across human cells @teichlab biorxiv.org/content/10.110…
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Are you looking for homologous sequences but alignments do not seem to work? SHARK-dive is available as a webserver 🦈: compare any sequences or search against precomputed IDR datasets: bio-shark.org @NAR_Open @csbdresden @PoLDresden MPI-CBG doi.org/10.1093/nar/gk…
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
HSDSnake: a user-friendly SnakeMake pipeline for analysis of duplicate genes in eukaryotic genomes. #SnakeMake #GeneDuplication #Genomics #Bioinformatics 💻 🧬 academic.oup.com/bioinformatics…
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
The HCA Archive Resource is now available for users, via the new Archive Discovery Portal. Established as a digital memory bank, the HCA Archive ensures the unique achievements of the HCA consortium are recorded and preserved. Learn more at humancellatlas.org/news/hca-archi…
This is so cool and a severely overlooked aspect of the TME and stroma: spatially disordered geometries of the microenvironment promote invasion shifts from collective to single mode. biorxiv.org/content/10.110…
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Thrilled to share our latest work now out in @naturemethods 🥳 We present SAVANA, a novel machine-learning based algorithm to detect somatic structural variants and copy number aberrations from long-read (@nanopore & @PacBio ) sequencing data with and without matched control!👇
Thrilled to share our latest work now out in @naturemethods 🥳 We present SAVANA, a novel machine-learning based algorithm to detect somatic structural variants and copy number aberrations from long-read (@nanopore & @PacBio ) sequencing data with and without matched control!👇
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Long-read 🧬sequencing reveals hidden cancer mutations, but existing tools often produce false positives. SAVANA is a machine learning algorithm trained on cancer genomes, built to make analysis faster and clinically reliable. ebi.ac.uk/about/news/res… #CancerResearch
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Thrilled to announce that our work on Expansion In Situ Genome Sequencing (ExIGS) is now published in @ScienceMagazine! ExIGS allows us to sequence DNA and image proteins with super-resolution directly within single cells. science.org/doi/10.1126/sc…
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
1⃣Small panels in #CODEX, #Xenium & #CosMx make fine cell typing tough. Our collab with @ZhuBokai , @SizunJ & @GarryPNolan brings #CellLENS! Published today in Nature Immunology: nature.com/articles/s4159….
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Check out our recent tool using deep learning to better discover immune cells in tissues! Always a pleasure to work with this great team: @ZongmingMa, @SizunJ, @GarryPNolan, @ironmathmo (Sheng Gao), @ShuxiaoC, @shaleklab and the rest who may or may not be on this platform!
Check out our recent tool using deep learning to better discover immune cells in tissues! Always a pleasure to work with this great team: @ZongmingMa, @SizunJ, @GarryPNolan, @ironmathmo (Sheng Gao), @ShuxiaoC, @shaleklab and the rest who may or may not be on this platform!
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Selection gene drives re-engineer tumors to suppress drug resistance go.nature.com/4bLLeFb rdcu.be/em30l
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Several mammal species live in cold-water environments thanks to adaptations like blubber and large size. A notable exception is the sea otter—so how does it stay warm? A 2021 Science study found an answer: skeletal muscle thermogenesis. Learn more on #WorldOtterDay:…
I hope we're finally getting it. The more we gatekeep "quality" science the more we leave it open to political attacks. We get funded to explore our curiosity so let's make sure our discoveries reach curious minds everywhere. Open access should just be FULL ACCESS.
I hope we're finally getting it. The more we gatekeep "quality" science the more we leave it open to political attacks. We get funded to explore our curiosity so let's make sure our discoveries reach curious minds everywhere. Open access should just be FULL ACCESS.
Mark Borris Aldonza (@precursorcell.bsky.social🦋) retweeted
Excited to share our newest paper, online today @Nature! We report the discovery of a highly unusual mechanism of antiviral immunity through the synthesis of long, homopolymeric DNA. nature.com/articles/s4158…
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2K Followers 4K Following Postdoc in @IgorUlitsky lab @WeizmannScience 🇮🇱| lncRNA, transcription, and chromatin enthusiast 🧬| #LGBTinSTEM 🏳️🌈| he/him | 🇩🇰🇪🇺
Yejing Ge @yejingge
384 Followers 434 Following Using skin as a model, the Ge Lab exploits mouse genetics and functional genomic approaches to study human diseases including cancer and aging.
Sandra Blanco Lab @Sblancolab
910 Followers 824 Following Epitranscriptomic and Cancer Lab. We aim to decipher the role of RNA modifications in cancer. @CSIC @ciccancer @usal
Jiamin Wu @JiaminWu7
284 Followers 307 Following Neurophotonics, computational microscopy, light field imaging, optical computing,
Berend Snijder @BerendSnijder
583 Followers 302 Following systems biology, pharmacoscopy, biological networks, big data, amsterdammer
Pedro Ortega @pedroorteg
322 Followers 603 Following Postdoctoral researcher at @RemiBuisson | @UCIrvine. Former PhD student at @AguileraLab | @unisevilla. Genome damage and Cancer Biology.
Cristian Prieto-Garci... @CristianPG_mlg
2K Followers 5K Following In @DikicLab @GoetheUni 🇩🇪. #Ubiquitination #Proteostasis #RNA #DNArepair #Cancer 🇪🇸. Past:@UnivCordoba @LaStatale @KingsCollegeLon @unicomplutense @Uni_Wue
Hae Kyung Im 任慧�... @hakyim
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Patrik Risteski @risteski_
938 Followers 1K Following Cell biologist interested in chromosome instability | @EMBO postdoc @Chapman_lab_UK @UniofOxford | PhD @Toliclab @institutrb | 🇪🇺Trends for United States
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