Robert C. Sharp, Ph.D. @RobertCSharpPhd
Biomedical scientist with specialization in genetics, immunology, clinical sciences Google Scholar: https://t.co/axdvcED2Hp Joined March 2022-
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I'm guest editing a #specialissue for @FrontImmunol, and we are looking for submissions of papers for our issue: Polyautoimmunity Development with Autoimmune-Associated Gene Mutations (frontiersin.org/research-topic…). Send papers! #polyautoimmunity #autoimmunity #Frontiers #Immunology
I am a guest editor of a #specialissue for @Cells_MDPI , and we are looking for submissions of papers for our issue: Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D) (mdpi.com/journal/cells/…) Please contribute your research! #type1diabetes #T1D #research #Cells #MDPI
Haven't post in awhile! I feel like I'm ready to get back into Twitter/X or whatever you call it now! Going to try to update this more frequently and highlight some cool papers out there in the #immunology field. Also wanting to advertise myself as well too! #backagain #scientist
Our #new #paper on how #flowcytometry methods and results are extremely variable across 58 studies looking at mouse brains. #systematicreview #immunology #mousebrain Experimental procedures for flow cytometry of wild-type mouse brain: a systematic review frontiersin.org/articles/10.33…
My old #postdoc #lab doing great work! Proud that I worked with such great people doing great #science to improve #treg functionality to reduce #t1d. #cd226 #diabetes #nodmice #mousestudies #mice #tcells #foxp3 #tcellregulation #molecularbiology diabetesjournals.org/diabetes/artic…
Our #preprint of a new #systematic #review based on determining #immunecell counts from #wildtype #mouse #brains via #flowcytometry. The field is #chaotic! Flow cytometry for immune characterization in homogenized mouse brain: A systematic review biorxiv.org/content/10.110…
A #study that shows opposite of what I have talked about in my #research. This group says that #SIRPalpha #SIRPa is NOT found on #pancreatic #betacells, but found on #Tcells. Just shows that the #CD47 #SIRP #signaling is still not fully understood journals.physiology.org/doi/full/10.11…
A great example of using #CRISPRCas9 #geneediting to show how #riskallele #SNPs can cause overactive #immunecell activity. A good mesh of my old #PhD project and my old #Postdoc project! Wish I had the technology back in the day to do this! #PTPN22 #Tcell doi.org/10.7554/eLife.…
Good #review about a specific subset of #diabetes called Latent Autoimmune Diabetes in Adults (#LADA), which doesn't get enough attention in the #autoimmune field. Discussion about different #immuneprofiles of LADA patients compared to both #T1D and #T2D. frontiersin.org/articles/10.33…
A #variant of #PTPN22 that could negatively regulate active PTPN22 proteins. Relatable to my old #research! Clinical value of the expression levels of protein tyrosine phosphatase non-receptor type 22.6 mRNA in PBMCs in Crohn’s disease academic.oup.com/cei/article-ab…
Hello everyone! Finally decided to get back into trying to keep this regular again! To start, here is a really good #protocol on #visualizing #immunecells from live #pancreatic tissues. jove.com/v/62207/observ…
Back at it again! A really good #review about how the #gutflora and #intestinalhealth is associated with #neurologicaldisorders and #neurologicaldiseases! #gutmicrobiota #immunity Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease mdpi.com/1422-0067/23/2…
Hey everyone! It's been awhile, but my wife and I have been a little busy...a new little #scientist in the making! Also another #UCFKnight in the making as well! I'll be back on #Twitter more later this month to provide great #science #papers!!! #UCF #LetsGoKnights
An interesting #study that looks at #serum levels of #IL1b #NLRP3 and #synuclein from #Parkinsonsdiease patients. The #inflammasome could play a bigger role in #pathogenesis! Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional... sciencedirect.com/science/articl…
A really great #review that is tying the #immunesystem to #neurodegenerative diseases, such as #Parkinsonsdisease together. Very exciting stuff! Parkinson disease and the immune system — associations, mechanisms and therapeutics rdcu.be/cUddf
This group found some potential new #genetic targets for #type1diabetes that could influence #immune #phenotypes! Good stuff! A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes doi.org/10.7554/eLife.…
More evidence that #HLA isn't the only #susceptibility #gene associated with not only #T1D, but with other #autoimmunedisease as well. Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects frontiersin.org/articles/10.33…
An interesting kind of "rebuttal" to my work as a #phdstudent. This group found that #PTPN2 #SNPs are NOT associated with #CrohnsDisease in #Indian patients. Shows how much #genetic differences there is between different countries when looking at SNPs! wjgnet.com/2150-5330/full…
Article about #LRRK2 #gene #overexpression in the context of #IFNgamma and #crohnsdisease pathogenesis. LRRK2 mutations are found in both Crohn's disease and #parkinsonsdiease, so might be a connection of #inflammation to #neurodegenerative diseases! pubmed.ncbi.nlm.nih.gov/20921534/
Starting off great here at the the Farrer lab! Starting to get into the weeds of further connecting #LRRK2 gene mutations not only to #Parkinsonsdisease, but also to general #brain #inflammation due to an overactive #immuneresponse, which is right in my wheel house! #immunegenes
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