Ruchi Malik @Ruchimk
neuroscientist @UCSF uncovering the mysteries of prefrontal inhibitory circuits | alum @UTAustin and @NCBS_Bangalore 🧠 profiles.ucsf.edu/ruchi.malik California, USA Joined February 2014-
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Finally getting this work out on Tsc1 in VIP+ interneurons. Great work from twitterless Jia Hu and @Ruchimk in the @sohallab. mdpi.com/2073-4409/13/1…
New paper from the lab out today! @jeremy_biane, @max_ladow and team describe how neural population dynamics in dorsal and ventral CA1 evolve with associative learning and outcome expectation. Full text here: rdcu.be/c83t3
New paper from the lab out today! @jeremy_biane, @max_ladow and team describe how neural population dynamics in dorsal and ventral CA1 evolve with associative learning and outcome expectation. Full text here: rdcu.be/c83t3 https://t.co/63tgeiq2d5
great to see this out! expertly crafted by @DaveKoop highlighting work from @mejoffe @Ruchimk @candelabellot and kirstie, hugo and hector who i dont have twitter handles for! PFC interneurons are cool! (esp when connected to hippocampus) jneurosci.org/content/42/45/…
During navigation, landmarks are encoded not in single cells but in the collective hippocampal population dynamics. Excited to be part of this work with @anagelhus Sebastian O. Andersson @soledad_gcogno @MayBrittMoser @KISNeuro #KiloNeurons #Neuropixels biorxiv.org/content/10.110…
Excited to see our paper on Unsupervised discovery of brain states in Hide and Seek out today on @CurrentBiology ! A massive exploration effort done by Bence Bagi @bagibence during his masters at @HumboldtUni in the @BrechtLab. That continued through years of pandemic.
So well deserved! Congratulations John! 🎉
Literature highlight of the week: Malik et al. identify a novel population of prefrontal long-range projecting interneurons that target VIP neurons in the hippocampus to increase spatial encoding and CA1-PFC gamma synchrony #top-down control sciencedirect.com/science/articl…
The net effect of all this is to enhance object-related spatial encoding by CA1 neurons and increase object exploration. IN SUMMARY: top down, doubly disinhibitory PFC inputs modulate CA1 network dynamics and information processing thereby promoting exploratory behavior (3/3)
These novel long-range projections GABAergic are actually DOUBLY DISINHIBITORY: by inhibiting disinhibitory VIP interneurons, they enhance feedforward inhibition in CA1. This also enhances the propagation of gamma oscillations across CA1 + PFC (2/3)
New paper! The PFC & hippocampus interact in many cognitive/emotional behaviors, but how the PFC exerts top-down control over hippocampus is a mystery. @Ruchimk found long-range GABAergic projections from PFC to hippocampus performing this function (1/3): authors.elsevier.com/sd/article/S00…
The Best Scientists 🧵 I have heard a lot about the Best Scientists 🧑🔬 Maybe the best scientists... make impactful discoveries, publish in gilded journals, garner millions in funding, with lots of indirects. And prizes, all the prizes🏆 And everybody respects them. OR…
We're back after a two-year hiatus! Inviting applications for CAMP (Computational Approaches to Memory and Plasticity), an international computational neuroscience school, in-person @NCBS_Bangalore, India. 23 Jul–7 Aug 2022. Details: camp.ncbs.res.in Please retweet!
2-photon imaging goes freely-moving! We are releasing @TheMini2P, a 2.4g portable #twophoton 🔬 for fast multiplane calcium imaging of 1000s of neurons in behaving 🐭! Fully open-access. Now it is time to study natural behaviors! By @WikiZong et al @KISNeuro #KiloNeurons #ERCSyG
2-photon imaging goes freely-moving! We are releasing @TheMini2P, a 2.4g portable #twophoton 🔬 for fast multiplane calcium imaging of 1000s of neurons in behaving 🐭! Fully open-access. Now it is time to study natural behaviors! By @WikiZong et al @KISNeuro #KiloNeurons #ERCSyG https://t.co/1DeOGOQESQ

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