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SGC Open Lab Notebooks @SGClabNotebooks

Scientists around the world are starting to share their laboratory notebooks online, in real time. We hope to inspire others to follow. Join us! Joined February 2018
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SGC Open Lab Notebooks @SGClabNotebooks

4 years ago

David Drewry and colleagues @thesgconline and @UNCPharmacy discover novel drug-like TBXT ligands against chordoma, a rare cancer: bit.ly/3jkjHBm

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Tamara Maiuri @McMasterU discovers that Huntingtin “coats” mitotic chromosomes when PAR break-down is inhibited. #OpenScience report: bit.ly/3apgY6d Blog: bit.ly/2NccQhk

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Setayesh Yazdani @thesgconline analyzes the druggability and genetic variability of #SARSCoV2 nsp14, a methyltransferase involved in evading host defense. #Openscience report: bit.ly/2L47MdY Blog: bit.ly/3s6CMuy #COVID19

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Fang-Chi Chang @thesgconline introduces her work on WDR12 and WDR55: bit.ly/3mWFOgX

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Evianne Rovers @thesgconline systematically annotates non-catalytic pockets on human enzymes for Proximity Pharmacology applications (including #PROTACs). #OpenScience report: bit.ly/37tTB9h Blog: bit.ly/3mkPJxy

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Setayesh Yazdani @thesgconline shows that the RNA-binding site of the #SARSCoV2 helicase nsp13 is druggable, highly conserved across coronaviruses and not mutated across 40,000 #COVID19 samples. #Openscience report: bit.ly/38xUGip Blog: bit.ly/2InCX2y

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Danton Ivanochko @thesgconline interrogates PRDM proteins, an understudied class of putative methyltransferases, for their ability to bind the cofactor necessary for enzymatic activity. #Openscience report: bit.ly/36mNL8M #epigenetics

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Alma Seitova @thesgconline refines a protocol to express and purify the ectodomain of #SARSCoV2 spike protein. #Openscience report: bit.ly/2GJopt3 Blog: bit.ly/3eI8Uyj #COVID19

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Setayesh Yazdani @thesgconline evaluates the druggability and genetic variability of an allosteric site of #SARSCoV2 RNA-dependent RNA polymerase. #Openscience notebook: bit.ly/3k2udLG #COVID19

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Mandeep Mann @thesgconline develops an assay to measure the activity of USP5 on di-ubiquitin substrates. #Openscience report: bit.ly/3mWiCzT Blog: bit.ly/32yfhiT

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Magdalena Szewczyk @thesgconline develops a NanoBRET assay to detect in cells the binding of Cyclin-E1 to the E3 ligase subunit FBXW7. #Openscience report: bit.ly/3oqkGBI Blog: bit.ly/35zYQDl #PROTAC

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Magdalena Szewczyk @thesgconline develops a NanoBRET assay to detect in cells the binding of β-catenin to the E3 ligase subunit FBXW11. #openscience report: bit.ly/3kwNdmQ Blog: bit.ly/3osT8LU #PROTAC

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Alma Seitova @thesgconline shares her protocol to produce and purify the receptor-binding domain of the #SARSCoV2 Spike protein from a transiently transfected mammalian cell. #Openscience report: bit.ly/2T5emkC Blog: bit.ly/35bYpPo #COVID19

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Alma Seitova @thesgconline shares her protocol to express and purify human ACE2, the cell-surface receptor for the SARS-CoV-2 Spike protein. #Openscience report: bit.ly/377cujp Blog: bit.ly/2SSqTHU #COVID_19

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Setayesh Yazdani @thesgconline analyzes the druggability and genetic variability of Remdesivir-bound SARS-CoV-2 RNA-dependent RNA polymerase. #Openscience report: bit.ly/2EkwbbB, blog: bit.ly/3kunb3c #COVID19 #remdesivir

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

David Drewry @thesgconline works on optimizing a chemical fragment that binds Brachyury, a possible protein target against chordoma : bit.ly/3gnPnCs @ChordomaFDN

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Liz Brown @thesgconline optimizes her protocol for RNP electroporation into patient derived #DIPG cell lines. #Openscience report: bit.ly/34iLc8j Blog: bit.ly/34jdXlA @M4KPharma

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Joseph Newman @thesgconline crystallizes the #SARS_CoV_2 helicase Nsp13 and screens a fragment library by crystallography. #Openscience report: bit.ly/3kRXGd9 Blog: bit.ly/3awawJn #COVID19

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Jong Fu Wong @thesgconline generates stable mammalian cell lines for the expression of proteins related to #COVID19. #Openscience report: bit.ly/2Bsx6oZ Blog: bit.ly/2ZXIi6x

SGClabNotebooks Profile Picture

SGC Open Lab Notebooks @SGClabNotebooks

5 years ago

Setayesh Yazdani @thesgconline evaluates genetic variability at the ADP-ribose binding site of the #SARS_CoV_2 Macrodomain Mac1, a potential target for antiviral small-molecules. #Openscience report: bit.ly/2EdoIeh Blog: bit.ly/2UQagOs #COVID19

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