Target 2035 @target2035
🌍 open science movement to develop by 2035 pharmacological tools for all human proteins; https://t.co/7QqI6Xb48s & https://t.co/SR2W97oLbs target2035.net Worldwide Joined August 2021-
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Wow!! Congratulations @BShoichet and others.
Wow!! Congratulations @BShoichet and others.
Need a #chemicalprobe? @Chemical_probes has reached 1000 chemical tools that have been reviewed by #drugdiscovery experts.
Need a #chemicalprobe? @Chemical_probes has reached 1000 chemical tools that have been reviewed by #drugdiscovery experts.
#AstraZeneca publishes on the challenges and impact on developing #highthroughput #thermalshift based #drugdiscovery High-throughput differential scanning fluorimetry (DSF) and cellular t... sciencedirect.com/science/articl…
Great to see the write-up of the GID4 E3 ligase handle PFI-E3H1. Kudos to the teams of #Pfizer and @thesgconline for their important contribution to the #Taget2035 initiative. More handles to come! @EUbOPEN #openscience #PROTAC biorxiv.org/content/10.110…
Stefan Knapp and Susanne Muller talk about how different stakeholders can contribute to high-quality research using small molecule tools. nature.com/articles/s4158…
“The hundreds of underperforming antibodies identified…were found to have been used in a large number of published articles” Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications elifesciences.org/reviewed-prepr…
We are happy to share that @target2035 will be featured in the upcoming @ChemBioSociety 2023 with a scientific session chaired by @CherylArrowsmi1. Among the speakers will be our very own @mattschap and Serah Kimani from @HalabelianLab. More details: chemical-biology.org
We are happy to share that @target2035 will be featured in the upcoming @ChemBioSociety 2023 with a scientific session chaired by @CherylArrowsmi1. Among the speakers will be our very own @mattschap and Serah Kimani from @HalabelianLab. More details: chemical-biology.org
A recent review by Edelris and AstraZeneca on "Affinity selection mass spectrometry speeding drug discovery" pubmed.ncbi.nlm.nih.gov/37660985/
@CarlLaflamme7 and @YCharOS1 were awarded for their work on antibody quality control experiments and for openly sharing data. Thank you @aimos_inc for acknowledging our effort to help researchers overcome a key problem in biomedical research. aimos.community/winners
@CarlLaflamme7 and @YCharOS1 were awarded for their work on antibody quality control experiments and for openly sharing data. Thank you @aimos_inc for acknowledging our effort to help researchers overcome a key problem in biomedical research. aimos.community/winners
Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning biorxiv.org/cgi/content/sh… #bioRxiv
Which is the best small molecule to validate the function of a protein in a disease setting? Diligence in the selection & use of such @Chemical_probes is needed. Here are some recommendations written w/ industrial & academic colleagues in @CD_AACR: @AACR aacrjournals.org/cancerdiscover…
Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels academic.oup.com/nar/advance-ar…
Excited to share our labs first preprint, where we develop a chemoproteomic approach to map the cellular interactomes of inhibitors and molecular glues! biorxiv.org/content/10.110…
Vivideon's first molecule, KEAP1 activator VVD-037, is in the clinic nature.com/articles/d4157…
Working with GSK, we find KLHDC2 is an effective proximity-induced degrader! cell.com/cell-chemical-…. Congratulations to @SaschaRoth41726, @nurkocaturk, @CartonBill, @PSathyamurthi and everyone who contributed. #TPD #PROTACs #degradation @mrcppu @UoDLifeSciences @maqueisser
📣The abstract submission deadline for #ICBS2023 has been extended to September 18th!!! Register before August 31 for early-bird price! Join ICBS membership to get member’s discount for the conference. For details, go to: chemical-biology.org
Experimental data for CACHE#2 Round#1 are out (1957 compounds predicted by 23 participants). 46 hits from 18 groups advance to hit expansion round. The wind is coming from expected AND unexpected places. Final results for CACHE#1 are next - in December. bit.ly/47uxBcq
All 1739 compounds shipped by Enamine in Kyiv and predicted by 25 CACHE#3 participants to bind SARS-CoV-2 NSP3 Mac1 are now received in Toronto. Screening by HTRF and DSF @thesgconline and by crystallography at UCSF's @fraser_lab about to begin! bit.ly/41HIW4X
Discover how SGC combines #protein expertise and partners of choice with #computational prowess to create a globally unique #OpenScience #drugdiscovery technology hub and get closer to the visionary goals of @target2035. Read more in our new blog post🔽 thesgc.org/node/1649631
Derek Lowe on the use and misuse of chemical probes and new criteria for degraders and covalent inhibitors. Appropriate use of probes is "just common sense" but sadly not that common. science.org/content/blog-p…
Dan Nomura @DanNomura
17K Followers 9K Following Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley; Departments of Chemistry and Molecular and Cell Biology
Stuart Schreiber @SchreiberStuart
11K Followers 367 Following Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Structural Genomics C.. @thesgconline
4K Followers 711 Following A public-private partnership supporting the discovery of medicines through open science. Sharing our news, science and reagents!
Katherine A Donovan @kdonovan1008
2K Followers 368 Following 🇳🇿 Kiwi | Scientist @DanaFarber @harvardmed | Targeted Protein Degradation | Chemoproteomics | Tweets are my own.
Radek Nowak @RPNowak
2K Followers 747 Following Professor @UniBonn. Former @DanaFarber @harvardmed | Targeted Protein Degradation | Chemical and Structural Biology | @UniofOxford alumni. Tweets are my own.
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
aled edwards @aledmedwards
3K Followers 41 Following Open access science and drug discovery. Founded and (still) direct @thesgconline. My comms folks shudder when I tweet.
Georg Winter @georg_e_winter
4K Followers 993 Following Chemical Biologist with passion for Cancer Research, Targeted Protein Degradation & Transcription.Scientific Founder of Proxygen & Solgate. Pats Fan. Dad.
Stephan Hacker @StephanHacker2
5K Followers 2K Following Assistant Professor @LeidenScienceEN. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. Also on https://t.co/OnUZrMJH69 and https://t.co/5xQ0wrIide. he/him/his.
Varun Shah @shahvarun28
360 Followers 433 Following Scientist @Dikiclab @ibc2_gu @proxidrugs | Targeted Protein Degradation
Luke Simpson @lukemsimpson
1K Followers 1K Following PROTAC Drug Discovery Scientist | Cell Biology | @AlessioCiulli @Boehringer Collaboration Team | Centre for Targeted Protein Degradation @UoDCeTPD
Michael Erb @Michael_A_Erb
2K Followers 903 Following Associate Professor @scrippsresearch. Chemical biology and gene regulation.
Matthieu Schapira @mattschap
1K Followers 115 Following Structural / Medicinal chemistry of epigenetic and ubiquitination target classes - CACHE challenges
Chris Parker @_chrisgparker_
2K Followers 820 Following Associate Professor @scrippsresearch | Department of Chemistry | chemical biology & chemical proteomics
Chemical Probes Porta.. @Chemical_probes
973 Followers 258 Following Expert recommendations and info about #ChemicalProbes, particularly small molecule inhibitors, and their use in biomedical research and #DrugDiscovery.
Fleur Ferguson @FleurMFerguson
2K Followers 942 Following Assistant Professor @UCSDChemBiochem @UCSDSkaggsSOP | Chemical Biology | Views my own | she/her/hers
Sergey Ovchinnikov �.. @sokrypton
12K Followers 3K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist
RSC Medicinal Chemist.. @rsc_medchem
8K Followers 1K Following Research and review articles in medicinal chemistry and related drug discovery science from the Royal Society of Chemistry (@RoySocChem)
Danette Daniels @danetteldaniels
1K Followers 543 Following Scientist, biophysics, cell biology, targeted protein degradation, and drug discovery. Adventure athlete, runner, and mountain biker | Opinions are my own
Christian Steinebach @c_steinebach
396 Followers 249 Following Dr. rer. nat.; Pharmacist; Dad; Postdoctoral Researcher in Medicinal Chemistry. Developing bifunctional probes for targeted protein degradation (PROTACs).
Wanetta Koenen @WKoenen60945
60 Followers 5K Following
Rebecka Isaksson @IsakssonRebecka
53 Followers 86 Following Research Fellow at UCL School of Pharmacy | FIP Scientific Secretary
Vikram Thimaradka @VikramT08
241 Followers 1K Following Postdoctoral Research fellow Broad Institute/Harvard Medical School | Ph.D. @Kyoto Univ. Chemical biology/Bioorganic chemistry/Therapeutics/Neuroscience
schlukas @schlukas1
13 Followers 273 Following
chunhiroshi @chunhiroshi1
0 Followers 10 Following
Maria @mariakutera
2 Followers 36 Following Graduate student in the Arrowsmith lab | structural biology @mbpatuoft
Open Chemistry De Gru.. @OpenChemistry
195 Followers 1K Following a peer-reviewed, and Open Access journal in the field of #chemistry from @DeGruyterOA! | IF(2023) = 2.3
Magnus Walter @magnuswwalter
70 Followers 413 Following Drug discovery scientist with eclectic interests; Anglo-German medicinal chemist; views are irrelevant and my own. He/him/his
Mercedes @loberame
14 Followers 435 Following
John Junwen Wang @wang_junwen
146 Followers 1K Following I develop #bioinformatics #methods for #SingleCell, #omics #DataIntegration, #DeepLearning Bioinformatician@MayoClinicCIM, @MayoGradSchool. Dad of 3 kids.
Anne-Sophie Pépin @annesopepin
342 Followers 770 Following Postdoc in Epigenetics at @HelmholtzMunich | BSc & PhD in Pharmacology at @mcgillu | she/her
S NP @SNP16349516
0 Followers 40 Following
ChemB @ChemBellenie
340 Followers 523 Following I’m a medicinal chemist and also teach medchem! Views my own. Mastodon @[email protected]
Daisuke Ogasawara @d_ogasa
45 Followers 109 Following Postdoc@Cravatt lab, Schreiber lab. @ScrippsResearch
Balakumaran Chandrase.. @kbcbkumaran7
318 Followers 1K Following Assistant Professor, BITS-Pilani India Carbohydrate analytics, Glycobiology, Plant-pathogen interactions, ChemicalProteomics, Plant/fungal Cell Walls
Dr. Jesse Coker @jcoker10
640 Followers 1K Following Structural & Chemical Biologist—Post-Doc @CCLRI—PhD @UniofOxford—Consultant @AgainstAMD—BS/BA @OUArtsSciences. Julie’s worse half.
OnlyGoodAntibodies @OGA_Community
74 Followers 84 Following OGA @OGA_Community Community with a primary goal of increasing the availability and use of high-performance antibodies.
ぐるー @molecular_gluer
12 Followers 142 Following Drug Discovery🧪, Chemical Biologist🧬, Induced Proximity🧲, Japan🇯🇵
Porkchop Express @jackburtonernie
109 Followers 294 Following
M H Shanto @Calcifer26
90 Followers 4K Following why talk about all the known n the unknown see how the unknown merges into the known why think separately of this life n the next when one is born from the last
W Yenjai @Proteoentist
35 Followers 996 Following Student at @MahidolU working on target deconvolution. #CellDeath #Ferroptosis Views are my own.
Theo @theodkatz
59 Followers 212 Following
Pete Sampson @pbsampson
68 Followers 329 Following
Larissa Delamare @DelamareLa19584
73 Followers 5K Following
Jin Wang 王津 @JinWangLab
671 Followers 745 Following Dad, husband, Michael E. DeBakey, M.D., Professor in Pharmacology @bcmhouston. Chemical biology, drug discovery, PROTACs & ADCs. We do🧪🧬 🐁 Views are my own.
Solveigh Koeberle @skoeberle9
137 Followers 173 Following Ferroptosis-modulating Redox Therapeutics ▪ Electrophilic Natural Products ▪ Redox Signaling ▪ Inflammation ▪ Cancer ▪ Degenerative Diseases
Jaimeen Majmudar @MajmudarJaimeen
73 Followers 375 Following
Michael Ronzetti @MRonzetti
462 Followers 1K Following NIH grad student in drug-discovery against #Lyme. Either bouldering or talking biotech. #UMich '16
Hannah Hope @hjhope
2K Followers 1K Following Open Research Lead, Research Environment @wellcometrust. Director @oaswitchboard. Wannabe cake maker and gardener extraordinaire.
Triangle @triangleperiod
337 Followers 5K Following
Agnieszka Konopacka @agako7
192 Followers 910 Following Scientist, Biologist, Targeted Protein Degradation drug discovery. All opinions are mine.
Manifesting @Zainab_ike
352 Followers 1K Following Young Theo Cray 😜 | winging life 🙃| learning to cook @emblebi
Conscience @consciencemeds
159 Followers 57 Following Conscience is a Canadian non-profit focused on AI drug discovery and open science.
Ben Reisman MD PhD @BenjaminReisman
1K Followers 3K Following PGY2 @OslerResidency via @VanderbiltMSTP • chemical biologist ⚗️• incoming fellow @Hopkins_HemOnc
ABDELMOUJOUD FARIS @ABDELMOUJO97961
49 Followers 493 Following Computer-Aided Drug Design Researcher. https://t.co/UzzXukvanc…
Xianke Meng @Xianke_Meng
13 Followers 406 Following Chemical Biology Research Fellow @DanaFarber @harvardmed PhD @UniUtrecht
JanF @jfscholtes
21 Followers 342 Following
Lisa Boatner @lisa_boat
120 Followers 355 Following computational scientist & chemical biologist @UCLA 🏔️ hiker | 🧗🏻♀️climber | 🎨 artist | 🤘🏻alum @UTAustin
Ari Selzer @Structzers
15 Followers 41 Following MBSB PhD Candidate in the Smithgall Lab at the University of Pittsburgh School of Medicine (he/him)
Mona AlQazzaz @mqazzaz
3K Followers 2K Following Human rights activist w/ focus on promoting rights of people w/ mental health& psychosocial disabilities. Personal views. RT≠endorsement. Tweets:Arabic&English.
Takahiro Maeda @TMHemOnc
394 Followers 407 Following Physician scientist, hematology/oncology @[email protected]
Peter Skopp @PeterSkopp
31 Followers 143 Following
Ingo Hartung @HartungIngo
14K Followers 779 Following MedChem @Merckgroup; drug discovery nerd in oncology, immunology & targeted protein degradation, soccer, politics or tapas can get into the way; my own views
Craig Crews @CraigMCrews
9K Followers 1K Following Yale Professor, Founder of @ArvinasInc, https://t.co/YoR6Yo3d3u Mastodon account: @[email protected]
Guillaume Laconde @Glaconde34
4K Followers 115 Following Medicinal chemist, specialized on PROTAC and #TPD technology OXELTIS Scientist, https://t.co/F8c4eERuOA Communication Deputy for the SCT, https://t.co/8j34whJXIQ Tweets = my own.
Carolyn Bertozzi @CarolynBertozzi
78K Followers 3K Following Prof. @StanfordUChem; Baker Family Director, @Stanford_ChEMH; @HHMINews Investigator; EIC of @ACSCentSci; She/Her 🏳️🌈
Dan Nomura @DanNomura
17K Followers 9K Following Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley; Departments of Chemistry and Molecular and Cell Biology
Jay Bradner, M.D. @jaybradner
22K Followers 938 Following Physician-scientist making medicines with friends, memories with family. EVP R&D and CSO at Amgen
Keith Hornberger @KRHornberger
11K Followers 288 Following Exec. director, medicinal chemistry @ArvinasInc | PhD @Columbia | hiker | beer & cocktail enthusiast | he/him/huz/dad | dreaming of @SedonaAZ | all posts my own
Stuart Schreiber @SchreiberStuart
11K Followers 367 Following Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Structural Genomics C.. @thesgconline
4K Followers 711 Following A public-private partnership supporting the discovery of medicines through open science. Sharing our news, science and reagents!
Darryl B McConnell @D_B_McConnell
7K Followers 379 Following drug discoverer, medicinal chemist, wannaberunner, wannabeartist, builder of ponds
Katherine A Donovan @kdonovan1008
2K Followers 368 Following 🇳🇿 Kiwi | Scientist @DanaFarber @harvardmed | Targeted Protein Degradation | Chemoproteomics | Tweets are my own.
Radek Nowak @RPNowak
2K Followers 747 Following Professor @UniBonn. Former @DanaFarber @harvardmed | Targeted Protein Degradation | Chemical and Structural Biology | @UniofOxford alumni. Tweets are my own.
Covalent Modifiers @CovalentMod
4K Followers 348 Following A feed for the blog https://t.co/pXYAKACULR. Discusses the covalent modification of proteins. Available on bsky and mass std don
David R. Liu @davidrliu
64K Followers 59 Following Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Alessio Ciulli @alessiociulli
6K Followers 382 Following Prof @Dundeeuni. Founder and Director @UoDCeTPD. Founder @AmphistaThera. We develop molecules that induce protein interactions and degradation
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
aled edwards @aledmedwards
3K Followers 41 Following Open access science and drug discovery. Founded and (still) direct @thesgconline. My comms folks shudder when I tweet.
Ryan Potts @pottslab
2K Followers 351 Following VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
Adam Gilbert @adammgilbert911
3K Followers 217 Following Executive Director of Medicinal Chemistry at Pfizer. Novel drug discovery strategies #proteindegradation #Covalents #dels #vaccines #PFEcolleague
Georg Winter @georg_e_winter
4K Followers 993 Following Chemical Biologist with passion for Cancer Research, Targeted Protein Degradation & Transcription.Scientific Founder of Proxygen & Solgate. Pats Fan. Dad.
Membrane Protein PDB @MemProtPDB
1K Followers 10 Following Listing publications containing membrane protein structures. #MembraneProteins #PDB #transporter #ionchannel #GPRC #cryoEM #crystallography #NMR #cryoET
Structure @Structure_CP
7K Followers 716 Following Structure is a monthly publication of @CellPressNews dedicated to research at the cutting edge of #structuralbiology. Tweets are by the Editors.
Peter J. Cullen @PeterJCullen1
1K Followers 352 Following Royal Society Noreen Murray Research Professor, University Bristol. Endosomal biology - molecular mechanisms in development, physiology and disease.
Charlotte Crowe @CharlCrowe
898 Followers 1K Following Final year PhD @dundeeuni with @AlessioCiulli / MChem 2020 @univofstandrews / originally from Strasbourg 🇫🇷
Zuzanna Kozicka @zkozicka
578 Followers 440 Following Postdoc @DFCI @BroadInstitute, previously PhD @LabThoma, Forbes 30U30 Science&Technology, @EdinburghChem graduate (she/her)
Margarida Espadinha @MargaridaEspad1
522 Followers 643 Following Postdoctoral Researcher at University of Antwerp | Medicinal Chemistry, Targeted Protein Degradation
Stegmaier Lab @KStegmaier_DFCI
1K Followers 193 Following Our research program focuses on the integration of "omic" approaches for the identification of new protein targets and small-molecule modulators of malignancy.
neomorphinc @neomorphinc
244 Followers 2 Following Solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’.
Proxygen @ProxygenTx
502 Followers 24 Following Proxygen develops innovative therapies against cancer and other life-threatening diseases by reprogramming the cellular protein quality control system
Coon Lab @Coon_Labs
3K Followers 1K Following Innovating mass spectrometry to drive biological discovery and advance human health.
PROXIDRUGS @proxidrugs
583 Followers 114 Following #Clusters4Future focusing on developing proximity-inducing drugs. Partners from pharma industry & @goetheuni, @Fraunhofer, @TUDarmstadt, @MPIbp, @UniHeidelberg.
Vienna BioCenter Scie.. @TrainingVbc
4K Followers 660 Following Vienna BioCenter Scientific Training Unit, we tweet about opportunities that exist @ViennaBioCenter, which include our PhD, Post Doc and Summer School programs
U of T Emerging and P.. @UofTEPIC
2K Followers 342 Following Preventing future pandemics and advancing public health through innovation, research and training. A partnership between @UofT and five affiliate hospitals.
CHARM Therapeutics @CHARMTherapeutx
992 Followers 1K Following Discovering & developing small molecule medicines against difficult-to-drug targets with our proprietary 3D deep learning-enabled platform, DragonFold
RSC BMCS @RSC_BMCS
2K Followers 3K Following Biological and Medicinal Chemistry Sector of the RSC. Dedicated to furthering interests of those involved in pursuit and understanding of bioactive molecules.
Viva Biotech @viva_biotech
55 Followers 228 Following We provide one-stop services ranging from early-stage structure-based drug R&D to commercial drug delivery for global biopharmaceutical innovators. #CDMO #CROs
Kedar Puvar @KPuvar
364 Followers 368 Following Easily inspired. @AbbVie Targeted Protein Degradation. Formerly @DanaFarber, @PurdueChemistry
Varun Shah @shahvarun28
360 Followers 433 Following Scientist @Dikiclab @ibc2_gu @proxidrugs | Targeted Protein Degradation
Adam Fletcher @E3ligase
661 Followers 744 Following New recruit at @CVRinfo, asking how cells deal with nasty viruses #UKRIFLF
Juha Huiskonen @JuhaHuiskonen
2K Followers 1K Following Director of Institute of Biotechnology @BIOTECH_UH, Professor of Structural Biology @helsinkiuni, Visiting Honorary Research Fellow @UniofOxford
Christopher Cooper @cooperotein
476 Followers 579 Following Director & Head of Protein Sciences @CHARMTherapeutx. Previously PI studying DNA replication/repair & archaea. Prokaryotic Div Chair-Elect @MicrobioSoc
ASAP Discovery @asap_discovery
436 Followers 27 Following The AI-driven Structure-enabled Antiviral Platform uses open science to develop accessible antivirals to prevent pandemics and seed global antiviral discovery.
Caroline Lynn Kamerli.. @kamerlinlab
9K Followers 7K Following Prof @GT_Chem @ga_res_alliance Eminent Scholar. Pianist, photographer, foodie, dreamer, mom. She/they. #FirstGen #MENA ❤️☀️💚 All views my own.
Joseph Watson @_JosephWatson
3K Followers 108 Following Co-Founder @ Xaira Therapeutics Former Baker Lab PostDoc at @UWproteindesign. Interested in generative modelling for molecular design. Views my own.
Wei Zhang @WeiZhangTO
890 Followers 698 Following Associate Professor @UofG_MCB My lab creates synthetic proteins as intracellular probes and novel therapeutic agents
Daniel Schramek @DanielSchramek
509 Followers 208 Following
Jody Mason @JodyMMason
603 Followers 547 Following Professor of Biochemistry, University of Bath. Tweeting (mostly) about our peptide and protein-based research.
MSD @MSDInvents
24K Followers 230 Following We aspire to be the premier research-intensive biopharmaceutical company.
Umesh Nair PhD @umeshjnair
144 Followers 574 Following Passionate about Advancing Research in Healthcare⚕️and Driving Innovation in Pharma 💊 Biotech 🧬 Life Science🔬
Boris Vauzeilles @BorisVauzeilles
2K Followers 1K Following director @ICSN_lab - president @SCF_ChemBio - BoD member and Secretary @ChemBioSociety - chemical biologist - synthetic chemist - glycochemist - views my own
FAIRplus @FAIRplus_eu
1K Followers 686 Following @IHIEurope project to improve data management and data governance in European health research. Coordinated by @ELIXIREurope and @JanssenGlobal
Stuart Conway @conway_group
5K Followers 2K Following Medicinal Chemistry and Chemical Biology research group. Stuart holds the Michael and Alice Jung Endowed Chair in Medicinal Chemistry & Drug Discovery at UCLA.
Will Farnaby @farnaby84
1K Followers 642 Following Father, friend, PI, scientist. Love discovering molecules that bring proteins together almost as much as I love bringing people together to discover molecules.
Ulrich Betz @UlrichBetz
885 Followers 460 Following Senior Vice President Innovation Merck KGaA, Darmstadt, Germany Member of the German Council for Science and Humanities
atai Life Sciences @atai_life
12K Followers 503 Following Healing #mentalhealth disorders so that everyone everywhere can live a more fulfilled life. Interested in #psychedelics & #drugdevelopment. $ATAI CEO @FloBrand.
Haselbach lab @HaselbachLab
2K Followers 581 Following #cryoEM enthusiast now also at @[email protected]
DegroBot @DegroBot
162 Followers 2 Following I am a bot retweeting #ubiquitin, #degron, #proteostasis, #PROTAC, and other protein degradation-related tweets. Creators: @n_szulc and @wojtek_pokrzywa
Rockefeller Universit.. @RockefellerUniv
20K Followers 1K Following The Rockefeller University is a world-renowned center for research and graduate education in the biomedical sciences, chemistry, bioinformatics and physics.
Mark Lautens @MarkLautens
7K Followers 364 Following Chair • ChemProf @UofT • Opinionated Science Advocate • @GlobeDebate • @NSERC Leader • @thiemechemistry EIC • #educateadvocate • my views only • science ++ more
European Biopharmaceu.. @EBRmagazine
952 Followers 421 Following European Biopharmaceutical Review (EBR) is a leading journal that provides beneficial information to players in the biopharma industry. #bio #pharmaceutical
Ubiquigent @ubiquigent
385 Followers 126 Following Ubiquigent enables the discovery and development of novel #deubiquitinase (DUB) modulators as powerful new #therapeutics
AI Proteins @AI_Proteins
2K Followers 22 Following better medicines, created rapidly through de novo protein design
Mark Dawson @MAF_Dawson
5K Followers 1K Following Fully support🇺🇦 Haematologist & Scientist @PeterMacCC and @UMCCR Group Leader @TheDawsonLab - views expressed are my own
Matchpoint Therapeuti.. @matchpointtx
106 Followers 1 Following Acing the future of covalent medicines
Roberta Tesch @RobertaTesch_
30 Followers 104 FollowingIn-depth perspective on the first CACHE challenge in @NatRevDrugDisc nature.com/articles/d4157… #compchem @thesgconline @consciencemeds
Excited to announce that qFit, an automated multiconformer modeling tool for X-ray and cryoEM, is now on @SBGrid! Try it out on your structures with 2Å resolution or above. And keep an eye out for our updated eLife paper elifesciences.org/reviewed-prepr…
Wow!! Congratulations @BShoichet and others.
Structure-based discovery of CFTR potentiators and inhibitors | bioRxiv biorxiv.org/content/10.110…
📅 Reminder: This is the last week to get your applications in for our Summer Undergraduate Research Program. The application window closes Friday at midnight!
📣Calling Canadian undergrads with an interest in Accelerated Discovery! Applications for our Summer Undergraduate Research Program are open. Gain exposure & training in machine learning, robotics, AI and automation, mentoring & more: acceleration.utoronto.ca/programs/summe…
🗨️ "It’s fantastic we have reached this milestone, both as a team and as the wider community. A huge thank you to our Scientific Expert Review Panel and the chemical probes community for helping us." - Paul Workman, Director of the Portal and Professor @ICR_London
Kudos to @Chemical_probes for reaching 1,000 compounds! A great collaboration with @target2035 to expedite chemical probe discovery.
🎉The Chemical Probes Portal has reached 1,000 compounds! We review hundreds of high-quality protein inhibitors and other tools for biomedical research, as well as 255 Unsuitables. Read more: chemicalprobes.org/news/1000-comp… #OpenScience #DrugDiscovery #TPD #degraders #ChemicalProbes
Great to see the write-up of the GID4 E3 ligase handle PFI-E3H1. Kudos to the teams of #Pfizer and @thesgconline for their important contribution to the #Taget2035 initiative. More handles to come! @EUbOPEN #openscience #PROTAC biorxiv.org/content/10.110…
Stefan Knapp and Susanne Muller talk about how different stakeholders can contribute to high-quality research using small molecule tools. nature.com/articles/s4158…
“The hundreds of underperforming antibodies identified…were found to have been used in a large number of published articles” Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications elifesciences.org/reviewed-prepr…
We are happy to share that @target2035 will be featured in the upcoming @ChemBioSociety 2023 with a scientific session chaired by @CherylArrowsmi1. Among the speakers will be our very own @mattschap and Serah Kimani from @HalabelianLab. More details: chemical-biology.org
🔬 Join us at #ICBS2023 for a special scientific session featuring @target2035, a global open science movement with to develop a modulator for every protein in the human proteome by 2035. Sponsored by @EUbOPEN. More details: chemical-biology.org
New @biorxivpreprint from @xzhang85 on: CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation biorxiv.org/content/10.110…
It’s just 4 hours until our 2023 #PDBArt exhibition opening event, celebrating the work of students in this year’s project, including scientific speakers and a guided tour of the virtual exhibition. 🗓️ 19th Sept 1700 BST ⬇️Register now embl-org.zoom.us/webinar/regist…
@CarlLaflamme7 and @YCharOS1 were awarded for their work on antibody quality control experiments and for openly sharing data. Thank you @aimos_inc for acknowledging our effort to help researchers overcome a key problem in biomedical research. aimos.community/winners
Honoured to have been selected, alongside our leader @CarlLaflamme7 , as the winner of the September 2023 AIMOS commendation award. Thanks @aimos_inc for recognizing our work that enhances research by openly sharing antibody quality control experiments! aimos.community/winners
Seminar Time Change:::::::Remember we are now starting webinars an hour earlier at 11am EDT/EST! See you on Thursday
Attend this week's #TPDWebinar featuring William Gibson @wgibson & Yevgeniy Serebrenik @YSereb. Update your Zoom calendar for the new start time: 11 am EDT/EST, 8 am PT/PST, 4 pm BST/BDT, 5 pm CEST/CE. We are starting 1 hour earlier!
WD40-repeat protein WDR91 is a Rab7 effector that couples Rab switching with #phosphoinositide conversion during #endosomal maturation x.com/jcellbiol/stat…
Spotlight—A new Rab7 effector controls phosphoinositide conversion in endosome maturation jcb.rupress.org/content/early/…
Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning biorxiv.org/cgi/content/sh… #bioRxiv
Which is the best small molecule to validate the function of a protein in a disease setting? Diligence in the selection & use of such @Chemical_probes is needed. Here are some recommendations written w/ industrial & academic colleagues in @CD_AACR: @AACR aacrjournals.org/cancerdiscover…
Wow!! Now this is really cool …biorxiv.org/content/10.110… @JustinGEnglish
Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels academic.oup.com/nar/advance-ar…
On September 14th, 12-7pm, dive deep into the world of protein degradation! Choose between in-person or virtual attendance. 🎙Seminars by: Bill Sellers (@TheSellersLab) Fleur Ferguson (@FleurMFerguson) Katherine Donovan (@kdonovan1008), panel, flash talks, networking.
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