Chris Parker @_chrisgparker_
Professor @scrippsresearch | Department of Chemistry | chemical biology & chemical proteomics parkerresearch.org San Diego, CA Joined May 2018-
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Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation. Nice work Wesley and Roy! pubs.acs.org/doi/10.1021/ac…
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Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews. biorxiv.org/content/10.110…
Chris Parker retweeted
Really cool @biorxivpreprint from @xzhang85 on expanding the repertoire of chemically induced covalent neo-antigens! biorxiv.org/content/10.110…
A big congratulations to the newly minted Dr. Forrest @InesForrest . Super proud!
A big congratulations to the newly minted Dr. Forrest @InesForrest . Super proud! https://t.co/yJnda3qiz7
Chris Parker retweeted
I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
Check out our recent efforts in @ChemRxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes. chemrxiv.org/engage/chemrxi…
Chris Parker retweeted
Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from @AmerChemSociety for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders. ow.ly/pbwV50UBnm9
Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds
Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds
Chris Parker retweeted
Great paper by the group of @_chrisgparker_. They further developed their AceTAG technology to also recruit the lysine acetyltransferase PCAF/GCN5. Together with their p300/CBP recruiter, this allowed in-depth insights into the function of p53 acetylation pubs.acs.org/doi/full/10.10…
Chris Parker retweeted
the first project of my PhD is now out @J_A_C_S ! super proud to introduce ABAP (my first acronym!) and share our findings on how lysine acetylation modulates protein function & interactions. so surreal to see this in print pubs.acs.org/doi/10.1021/ja…
Chris Parker retweeted
Proud to share my first, first-author paper of graduate school! This year-long detour started with “we made a neat tool - what biology can we figure out with it?” Turns out we can find regulators of placental cell differentiation. pubs.acs.org/doi/10.1021/ac…
Chris Parker retweeted
We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily (biorxiv.org/content/10.110…)!
Chris Parker retweeted
Excited to share a key part of my postdoctoral work in the Cravatt lab at @scrippsresearch, published today in @NatureChemistry! Huge thanks to collaborators @brumelillo, @_RachelHayward, @VividionRx, and all coauthors.
Chris Parker retweeted
Excited to share this @CellChemBiol Review I wrote with Ben Cravatt highlighting recent applications of ABPP for ligand discovery. We highlight the expansion of ABPP beyond enzyme active sites with a special focus on covalent ligands. Enjoy! tinyurl.com/48cyaj6d
Chris Parker retweeted
Very honored to be one of 19 graduate students recognized by the @AmerChemSociety and @ACSGradsPostdoc for leadership in the important mission of promoting diversity, equity, inclusion and respect! Congrats to all the other awardees, together we are making a difference! 🌟
Happy to share new work led by recent grad @AnnyChe77788549 and @SinghaSoumya. Here, we expanded our AceTAG platform to include PCAF/GCN5 & used this toolbox to investigate functional consequences of targeted p53 acetylation. w/@Michael_A_Erb. @ACSBioMed pubs.acs.org/doi/full/10.10…
Chris Parker retweeted
pubs.rsc.org/en/content/art… No 1⃣1⃣ Check out this intriguing mechanistic study on dialkyldiazirines by @FoxGroupUD (@UDelaware), @_chrisgparker_ (@scrippsresearch), @ChrisamEnde1 (@pfizer). Grateful to be part of this work all the way from @univienna!! @azidoalcohol @MaulideLab
Chris Parker retweeted
Congrats to Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, on receiving the 2024 Heinrich Wieland Prize. His work on disease-causing proteins and activity-based protein profiling is advancing drug discovery. ow.ly/Jgze50T4xUE
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