Sarah H. Shahmoradian @ShahmoraLab
Assistant Professor @UTSWBrain. Using electrons to dissect how proteins behave and misbehave in the brain. Engineering new tools for cryoEM in situ. ⚙️🧠❄️⚛️🔬 labs.utsouthwestern.edu/shahmoradian-l… Dallas, Texas Joined October 2021-
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Sarah H. Shahmoradian retweeted
A UT undergrad wrote a very interesting paper that uses neural cellular automata to solve some of the Abstraction and Reasoning Corpus (ARC) AGI benchmark problems. @TexasScience arxiv.org/abs/2506.15746
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Sarah H. Shahmoradian retweeted
1/8 Cryogenic electron tomography (cryoET) is a revolution already in motion! @MishaKudryashev argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: tinyurl.com/4x4bf9ze Let’s unpack that 👇 #CryoET #StructuralBiology
Sarah H. Shahmoradian retweeted
We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena Vazquez-Sarandeses, Vasya @v_mikirtumov Jeff Noel&Oli Daumke biorxiv.org/content/10.110…
Sarah H. Shahmoradian retweeted
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... @theliulab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️biorxiv.org/content/10.110…
Sarah H. Shahmoradian retweeted
Our manuscript for remote focus stabilization for oblique plane microcopy is online: opg.optica.org/boe/fulltext.c…
Sarah H. Shahmoradian retweeted
Last night my brilliant friend with 20 years of expertise in Neuroscience including a decade at NIDA was fired because she was recently promoted for her outstanding performance and it triggered the probation period. This is not making NIH more efficient, this is not making us…
Sarah H. Shahmoradian retweeted
"Don't be afraid!" Randy Schekman says that the most successful scientists are willing to take risks. He uses 2024 chemistry laureate David Baker as an example of how embracing risk can lead to significant rewards. Before Baker transitioned to researching structural biology he…
Sarah H. Shahmoradian retweeted
Hi, it’s nice to meet you. I am a #brain scientist. My life's mission is to prevent #Alzheimer’s disease and related dementias...or to contribute enough puzzle pieces so that someone else can unlock the mysteries of disease. I might take a day off, but if I’m being honest, maybe…
Sarah H. Shahmoradian retweeted
Interesting in learning to process cryo-ET data in the latest version of Warp? I'll be running a workshop on April 22nd in central London, UK details+registration: forms.gle/u4Hk73jhenMvpN… Hope to see you there!
Sarah H. Shahmoradian retweeted
The self driving multi-scale microscope from @Daetwyler_St is out. It can image a whole zebrafish embryo longitudinally and follow a region of interest with high resolution. We use it to study immune-cancer cell interactions. nature.com/articles/s4159…
Sarah H. Shahmoradian retweeted
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" biorxiv.org/content/10.110… We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during vesicle fusion ❄️🔬⏱️
Sarah H. Shahmoradian retweeted
We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics
Sarah H. Shahmoradian retweeted
Our experience with #alphafold3 🤖 (code recently released) and some of our most recent #cryoEM 🔬 structures (thread below) nature.com/articles/s4158… nature.com/articles/s4146…
Sarah H. Shahmoradian retweeted
HHMI Investigator Joshua Mendell (@Mendell_lab) at @UTSWMedCenter helped discover that tRNAs play a role in stabilizing or degrading some mRNAs during translation. Their findings could one day help tailor vaccines and disease therapies. Learn more: hhmi.news/4hZMqJa 👈
Sarah H. Shahmoradian retweeted
I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…
Sarah H. Shahmoradian retweeted
🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances . Equal-first co-authors @LuptonCJ & @sci_laura. Work lead by @Dr_Ellisdon. Funding from @DeptofDefense & @arc_gov_au. science.org/doi/10.1126/sc…
Sarah H. Shahmoradian retweeted
RhoFold+ is an end-to-end language model-based deep learning approach for predicting 3D structures of RNAs. nature.com/articles/s4159…
Sarah H. Shahmoradian retweeted
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…
Sarah H. Shahmoradian retweeted
Oh wow. This is gonna be super tricky to figure out what to do now. There isn’t any easy automated way to install a full deep learning stack from scratch after this change afaict.
Oh wow. This is gonna be super tricky to figure out what to do now. There isn’t any easy automated way to install a full deep learning stack from scratch after this change afaict.
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438 Followers 346 Following Post doc @swuliuslab , CryoET, Convolutional neural network segmentation, Image analysis, https://t.co/LTsqVGFBYD
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5K Followers 2K Following asst prof @UTAustin physics interested in chaos, fluids, & biophysics.
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591 Followers 515 Following Assistant Professor at School of Biological Sciences, Nanyang Technological University, Singapore. NRF fellow, Postdoc@Cornell, PhD@Tokyo Tech
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397 Followers 506 Following PhD in Structural Biology. cryo-electron microscopist. Scientist by day, sewist by night. #CryoEM Product Specialist @ Thermo Fisher Scientific
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843 Followers 542 Following Hijai R.Shin in publications. PhD @SeoulNatlUni, Postdoc @berkeleymcb, Assistant professor @CRI_UTSW. Interested in #autophagy #lysosome, metabolism, cancer.
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Amar Sahay @AmarSahay_
3K Followers 1K Following Professor @harvardmed & MGH. Engineering strategies to enhance cognition since 2011. Dad. Husband. Marathoner. 🦈 Diver. Also at https://t.co/WOlBKYMhirTrends for United States
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