Sharp Laboratory @Sharp_Lab
Assistant Professor @USFHealth, Cardiovascular Scientist, #Cardiometabolic Disease, #HeartFailure @ECI_ISHR https://t.co/0hfSNN8buc healthscholars.usf.edu/sharplab Joined July 2023-
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Save the Date 2027. @LeferLab @VCUHealthHeart @SALLOUMFN @Sharp_Lab
Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction jamanetwork.com/journals/jama/…
In the STEER study, there were 15 (0.1%) cardiovascular events recorded with Wegovy®, and 39 events (0.4%) were recorded with tirzepatide. The average follow-up duration was 3.8 months for the Wegovy® group and 4.3 months for the tirzepatide group. #ESC2025 #CVD #Heartdisease
In the STEER study, there were 15 (0.1%) cardiovascular events recorded with Wegovy®, and 39 events (0.4%) were recorded with tirzepatide. The average follow-up duration was 3.8 months for the Wegovy® group and 4.3 months for the tirzepatide group. #ESC2025 #CVD #Heartdisease https://t.co/TPbqYPpvaB
🚨 #HFpEF ≠ #HFrEF! Turns out, the #immunesystem knows the difference. We profiled #immunecells in HFpEF patients (scRNA-seq) & mice-showing conserved inflammatory programs & the therapeutic potential of #NO₂-OA. 👉 doi.org/10.1161/CIRCRE… @jasminkneuer
💊 Can an exercise pill ever replace the gym? A new review says no, and here’s why: 🏃♂️ Exercise upgrades every system at once: ✳️Mitochondria fuse, burn fuel & handle ROS ✳️Inflammation falls as exerkines flood the blood ✳️Vessels dilate, plaques stabilize, BP drops ✳️Heart…
In rodents, there is evidence that alcohol intake induces a re-organization of the gut microbiome, driving up levels of a microbial metabolite (PAGln) that promotes cardiovascular disease. This effect can be transferred to other mice via microbiome transplantation.
Acute exercise doesn’t just stress muscles; it reshapes the gut. 🧬🏃♂️ Even one workout transiently rewires gut microbial activity, hinting at a mechanistic link between exercise, microbiota, and host performance. A review in Experimental Physiology shows a single bout of…
🚨New Publication Alert!🚨 A collaborative study between @TheElrodLab & @LeferLab out now in #JACCBTS ! The team reports the metabolic and gene expression changes driving heart failure with preserved ejection fraction (HFpEF). This study lays the groundwork for future therapies!
Editorial to jacc.org/doi/10.1016/j.… Cracking the Code of a Preclinical Rodent Model of HFpEF: The Mitochondrial Link | JACC: Basic to Translational Science @LeferLab @SmidtHeart @Sharp_Lab @CardioMetaboSci jacc.org/doi/10.1016/j.…
Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF | JACC: Basic to Translational Science @LeferLab @SmidtHeart @Sharp_Lab @CardioMetaboSci jacc.org/doi/10.1016/j.…
Editorial to - jacc.org/doi/10.1016/j.… Smells Like Therapy: Targeting Sulfur Signaling in Cardiometabolic HFpEF | JACC: Basic to Translational Science @LeferLab @SmidtHeart @Sharp_Lab . jacc.org/doi/10.1016/j.…
H2S Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergy w/ GLP-1/Glucagon Agonism | JACC: Basic to Translational Science @LeferLab @SmidtHeart @Sharp_Lab @HFpEFSummit jacc.org/doi/10.1016/j.…
Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy: Cell cell.com/cell/fulltext/…
“Physiological Principles of Exercise” Fundamentals of “Aerobic” and “Anaerobic” respiration mechanisms within the Skeletal Muscle 👇🏼 NEJM 2025 Review #exercise #muscle #cardiorespiratory #physiology evidence.nejm.org/doi/full/10.10…
2 new interesting gut microbiome studies: —Reshaping via diet rich in fermentable CHO and metformin for better glycemic control, RCT nature.com/articles/s4225… @NatMetabolism —Common gut bacteria make polypeptides that may have therapeutic value nature.com/articles/s4156……
🚨 Session 14: Pathophysiologic and Systemic Axes Beyond the Heart is live at #BCVS25! From renal denervation to fat-heart crosstalk, brain-heart axis, and splenic B cells—today’s talks are bridging systems for deeper insight into heart disease. @Sharp_Lab @AHAScience
Here Professor Schertzer and colleagues identify that microbial-derived D-lactate contributes to host glucose and lipid metabolism and can be trapped therapeutically to improve metabolic disease during #obesity cell.com/cell-metabolis…
A new comprehensive review of the proglucagon-derived peptides #disbetes #obesity #shortbowelsyndrome journals.physiology.org/doi/abs/10.115…
New content online: Body weight regulation models in humans: insights for testing their validity bit.ly/45js611
RESEARCH | @clarissamliu, @DanielJDrucker, M Véniant et al (@Amgen, @SinaiHealth) Part 1: This study and a co-pub delve into how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms. nature.com/articles/s4225…
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The Journal of Cardio... @JCA_Journal
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