Wiep Klaas Smits @SmitsLab
Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social lumc.nl/smits Leiden, Nederland Joined August 2015-
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Wiep Klaas Smits retweeted
Out Now! Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism bit.ly/3U4vFlt #Polypeptides #GutHealth #Microbiome
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Wiep Klaas Smits retweeted
You may have heard of combination antibiotic therapy 💊💊but have you heard of antibiotic potentiator 💊➕combination therapy? Find out more below 👇 nature.com/articles/s4425…
Looking back at a great #clostpath2025 (Paris), and ahead to #icds2026 (Bled) and #clostpath2027 (Rio de Janeiro).
Ancient host-associated microbes obtained from mammoth remains sciencedirect.com/science/articl…
Our collaborative work with colleagues from Serbia on the notable RT955 is now out in EMI: tandfonline.com/doi/full/10.10… cc @EdKuijper2
Hallmarks of DNA replication stress responses in Escherichia coli and Bacillus subtilis academic.oup.com/femsre/article…
Veillonella intestinal colonization promotes C. difficile infection in Crohn’s disease: Cell Host & Microbe cell.com/cell-host-micr…
Wiep Klaas Smits retweeted
Out Now! Metabolic reprogramming enhances the susceptibility of multidrug- and carbapenem-resistant bacteria to antibiotics bit.ly/3HsuQA8 #MetabolicReprogramming #Antibiotics #BacterialResistance
Wiep Klaas Smits retweeted
A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a…
The Escherichia coli replication initiator DnaA is titrated on the chromosome nature.com/articles/s4146…
Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters microbiologyresearch.org/content/journa…
Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile | ACS Infectious Diseases pubs.acs.org/doi/10.1021/ac…
An endoribonuclease of the YicC-like family delays sporulation via sRNA degradation in Clostridioides difficile academic.oup.com/nar/article/53…
Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases | The EMBO Journal embopress.org/doi/full/10.10…
Now online at Emerging Microbes and Infection: tandfonline.com/doi/full/10.10…
Now online at Emerging Microbes and Infection: tandfonline.com/doi/full/10.10…
Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-L-methionine biorxiv.org/content/10.110…
c-di-GMP-Dependent Regulation of Motility by comFB and comFC biorxiv.org/content/10.110…
Clostridioides difficile toxins alter host metabolic pathway and bile acid homeostasis gene expression in colonic epithelium | Infection and Immunity journals.asm.org/doi/10.1128/ia…
Wiep Klaas Smits retweeted
New paper published in Nature Microbiology! 🆕 📃 🥼 Led by Narciso Martín from IBFG in collaboration with the University of Salamanca and Université Laval ⚙️ This study introduces FungAMR and ChroQueTas — two groundbreaking tools to tackle antifungal resistance 🧶⬇️
Kabli, A.F., Ng, I.W., Read, N. et al. Coupling chromosome organization to genome segregation in Archaea. Nat Commun 16, 6759 (2025). doi.org/10.1038/s41467…
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