Parallel Squared Technology Institute (PTI) @ParallelSqTech
PTI is a nonprofit focused research organization scaling proteomic technologies to explore proteome biology. A member of the @SchmidtFutures & @Convergent_FROs. parallelsq.org Boston, MA, USA Joined February 2023-
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We share our technologies to maximize the benefit for the community. PSMtags enable 9-plexDIA with better sequencing and multiplexing. PSMtags support sensitive proteomic analysis of over 1,000 samples / day. parallelsq.org/psmtags
Protein degradation is often considered as a final step in regulating gene expression. It also regulates the first step: Transcription Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥: ⬛️ It has a key advantage. 👇
Protein degradation is often considered as a final step in regulating gene expression. It also regulates the first step: Transcription Many TFs, including p53, HIF-1α and c-Myc, are regulated by 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧-𝐠𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐭𝐫𝐨𝐥: ⬛️ It has a key advantage. 👇
The registration for SCP2026 is open ! Join us next July for the the 9th Single Cell Proteomics Conference. single-cell.net/proteomics/scp…
Scaling DNA sequencing is a notable success story. Scaling protein analysis is harder since the proteome is a much taller mountain: nature.com/articles/s4159… @AsimovPress writes about @ParallelSqTech's approach to scale up proteomics.
Increasing throughput is particularly helpful when it also increases data quality. 🚀
Increasing throughput is particularly helpful when it also increases data quality. 🚀
A succinct and clear presentation of multiplexing proteomic technologies that we developed at @ParallelSqTech.
A succinct and clear presentation of multiplexing proteomic technologies that we developed at @ParallelSqTech. https://t.co/V4lHih4SKr
PTI will be represented at #ASMS2025 with with two posters (TP203 and ThP 533) and two talks (TOA 2:30 pm and WOA 8:30 am). Find us to hear about our PSMtag, and applications in Alzheimer's and aging biology!
🟦 Label-free single-cell proteomics (blue bars). 🟧 Multiplexed single-cell proteomics affords higher throughput (orange bars). ⬛️Proteome depth & quantitative accuracy are comparable. We aim to make the 🟧 bars taller. parallelsq.org/psmtags biorxiv.org/content/10.110…
The next generation plexDIA tags are looking promising !
The next generation plexDIA tags are looking promising !
Find PTI's preprints at the PTI bioRxiv channel: connect.biorxiv.org/relate/summary…
Find PTI's preprints at the PTI bioRxiv channel: connect.biorxiv.org/relate/summary… https://t.co/NH7XOLQ6ep
Leading these (and many ongoing) projects has been demanding, exhilarating & rewarding. They required highly coordinated collaborations among diverse experts within PTI, MIT, MGH and beyond. 1/2
Leading these (and many ongoing) projects has been demanding, exhilarating & rewarding. They required highly coordinated collaborations among diverse experts within PTI, MIT, MGH and beyond. 1/2 https://t.co/14S0QzNe5P
Furthermore, we identify coherent sets of ubiquitin system enzymes, proteins that target substrates for proteasomal degradation, whose levels robustly discriminate AD from non-AD samples. One subset exhibited consistent increases in AD, while another exhibited consistent…
Alzheimer's disease (AD) is associated with numerous proteome changes. We find large & consistent decrease in the abundance and stoichiometry of 20S proteasome subunits. ⬛️ It leads to abnormal accumulation of 20S substrate proteins. biorxiv.org/content/10.110…
Alzheimer's disease (AD) is associated with numerous proteome changes. We find large & consistent decrease in the abundance and stoichiometry of 20S proteasome subunits. ⬛️ It leads to abnormal accumulation of 20S substrate proteins. biorxiv.org/content/10.110… https://t.co/0Z164cZGGp
We performed global and systematic proteome analysis of Alzheimer's disease (AD). Our results suggest that decreased ubiquitin-proteasome system capacity and impaired clearance of proteins contribute substantially to proteopathic burden in AD. biorxiv.org/content/10.110…
#SCP2025 continues with a hands-on workshop at PTI @ParallelSqTech single-cell.net/proteomics/scp…
We just released JMod: an open source software supporting multiplexed DIA. It supports parallelization in both the mass domain (plexDIA) using small mass offsets and in the time domain (timePlex). It enabled 27-plex DIA & much further scaling 🚀 biorxiv.org/content/10.110…
We just released JMod: an open source software supporting multiplexed DIA. It supports parallelization in both the mass domain (plexDIA) using small mass offsets and in the time domain (timePlex). It enabled 27-plex DIA & much further scaling 🚀 biorxiv.org/content/10.110… https://t.co/b05SODOKui
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