Tenzer Lab @TenzerLab

Focusing on quantitative proteomics using ion mobility and data-independent acquisition techniques Mainz, Germany Joined December 2019

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

3 PostDocs and 2 PhD students drive the project #BETTERWHEAT. Besides large coordination efforts, tasks encompass phenotypic analyses of field data, genome-wide association mapping, proteome profiling and the use of machine learning for prediction of baking quality

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 1: 282 wheat cultivars originated from D and surrounding countries from different decades of breeding. They differed in agronomic and quality traits; e.g. yield ranged from 7.3-10.7 t/ha, bread loaf volume between 472-782ml & flour yield between 35-60%

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 2: Loaf volume from rapid-mix-test correlated most strongly (r = 0.7) with protein content and Extensograph, followed by SDS, Glutograph and Glutopeak. Methods describing starch quality (falling, RVA, amylase activity) did not correlate with loaf volume.

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 3: Three different spectrometers were used to predict quality parameters of wheat cultivars. Correlations between predicted and measured values were surprisingly high (r > 0.8) for many quality traits like loaf volume, SDS and water uptake of dough.

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 4: Starch properties measured by RVA correlated tightly with falling number (r>0.8), while correlation between α-amylase activity and falling number was lower (r = -0.68). Joint major QTLs influencing at least two of these traits were found

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 5: Testing cultivars registered during different decades of breeding, we show that breeding has improved disease resistance & grain yield, and bread loaf volume was maintained due to improved SDS although a reduction in protein content was visible

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 6: Mineral content (Fe, Zn, P, S) of wheat cultivars was positively correlated with their protein content (r > 0.6), but negatively with yield (r < -0.5). Selection for baking quality needs compromise for yield but could be combined with mineral content.

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 7: One joint genomic region (major QTL) was found influencing protein & mineral content but 2 of 4 major QTLs found for Zn and yield were in close genomic vicinity with opposite trait effects explaining partly the negative correlation of yield and Zn content

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 9: Protein content & grain yield were strongly correlated, which was partly influenced by genes located in similar genomic regions. Similarly, 11 proteins influenced grain yield and protein content with 5 of them having QTLs within above genomic regions

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Prof. Dr. Friedrich Longin @friedrichlongin

9 months ago

#Betterwheat results 8: High-throughput LC-MS proteomics was established @TenzerLab delivering >6.000 proteins for 1.200 samples (282 wheat cultivars grown at 4 locations) representing the first “pan-proteome” of wheat grain. ~100 proteins had high correlations to quality traits

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Julian Beyrle @JulianBeyrle

11 months ago

Big shoutout to @TenzerLab, @DavidGomezZep, and my fantastic colleagues for their support. Learn more about MAETi and stay tuned for the upcoming preprint! (3/3) #TeamMassSpec #immunopeptidomics

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Julian Beyrle @JulianBeyrle

11 months ago

The event was an incredible learning experience in #proteomics while reconnecting with old friends and making new ones in the community. Special thanks to #DGPF and @hupo_org for supporting my journey with a travel grant. (2/3)

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Julian Beyrle @JulianBeyrle

11 months ago

Thrilled to have shared our latest research on "MAETi: Mild Acid Elution in a Tip enables MS-based immunopeptidomics profiling from as low as 50,000 cells" at #HUPO2024 in Dresden! (1/3)

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Human Protein Atlas @ProteinAtlas

11 months ago

A new version 24 of the Human Protein Atlas resource has been released at the HUPO meeting in Dresden, Germany. The data is summarized in eight resources covering different aspects of human protein-coding genes in tissues, cells, cell lines and blood. proteinatlas.org/news/2024-10-2…

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Mushtaq Bilal, PhD @MushtaqBilalPhD

a year ago

☹️Google Scholar is a great tool. But it doesn't show how papers are connected with each other. 😀Here's how to fast-track your literature review with a "visual search." And export your papers to Zotero, Mendeley, or EndNote. You can learn this workflow in 15 min:

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DKFZ Immunology Infection and Cancer @DKFZImmunology

a year ago

Follow this excellent tutorial if you want to improve your DDA-PASEF acquisitions with Thunder-DDA-PASEF and ensure high-coverage immunopeptidomics analyses ⬇️ Huge congrats to @TenzerLab @DavidGomezZep and co-authors for this fantastic work recently published in @NatureComms! 👏

DavidGZ @DavidGomezZep

a year ago

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DKFZ @DKFZ

a year ago

Apply now for the Summer Selection of the International #PhD Program at the German Cancer Research Center, covering all areas of #cancerresearch, including #datascience, #bioinformatics, #epidemiology, #medicalphysics. To apply for your #PhDatDKFZ visit ➡️ t1p.de/3f58d

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Tenzer Lab @TenzerLab

a year ago

Job Alert 🌟 We are recruiting a postdoc in #lcms based #immunopeptidomics in our group @HITRONMainz - position is fully funded for two years. Check the job description and apply here: jobs.dkfz.de/en/jobs/166492… Please RT!

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Tenzer Lab @TenzerLab

2 years ago

Want to learn how to optimize your #DDA-PASEF acquisition for #immunopeptidomics? Use Thunder-DDA-PASEF! See our paper by @DavidGomezZep from @HITRONMainz: rdcu.be/dA7di Thanks to a wonderful collaboration with @compomics and @ChristineCARAP1!