Luke Khoury @_lukekhoury
Quantitative biology with mass spectrometry. @slavovLab Joined August 2021-
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We are excited to introduce ‘time’ as a new domain for proteomics multiplexing! It enables: -Label-free multiplexing -Combinatorial multiplexing with plexDIA Using 9-plexDIA and 3-timePlex together we demonstrate 27-plex DIA 🚀 biorxiv.org/content/10.110…
Our paper on the impact of protein leakage due to loss of membrane integrity for single cell proteomic sample prep is out in @NatureComms! We analyze thousands of primary single cells from murine tracheal tissue and record membrane permeability🧵 nature.com/articles/s4146…
Our perspective in Free Radical Biology and Medicine is now published! We highlight the risk of inducing pericellular anoxia with physioxic and hypoxic culture and provide methodologies to control pericellular oxygen. doi.org/10.1016/j.free…
How are proteins regulated across single cells of human tissues ? We developed a Bayesian model (BayesPG) for inferring protein regulation from single-cell protein & RNA data. For 28 % of proteins, abundance differs significantly from ... 🧵 biorxiv.org/content/10.110…
Cellular states prior to stimulation will be predictively associated to outcomes. By linking variable proteomes to responses, we may identify regulators. biorxiv.org/content/10.110… Here, we use single-nucleus proteomics to identify regulators of LPS-induced protein transport🧵
Our latest article is out: It focussed on the proteome remodeling during epithelial-mesenchymal transition. ◼️ Much of the remodeling was reflected only in the protein covariation across the proteomes of individual cells. biorxiv.org/content/10.110…
Our new preprint is available on biorXiv: doi.org/10.1101/2023.1… !🥳 We present scplainer, a principled computational approach to streamline and standardise #MassSpec #SingleCell #proteomics data analysis. Here's a 🧵 with our key messages.
Mass spec proteomics is rocketing 🚀 Its sensitivity & throughput are rocketing 🚀 What was impossible with bulk samples can now be performed with single cells in just a small fraction of the time! blog.slavovlab.net/2023/11/29/pro…
Large-scale multiplexed single-cell proteomic experiments require flexible and high-throughput sample preparation. nPOP can now be more seamlessly and robustly integrated into research pipelines to facilitate the demands for biological discovery. biorxiv.org/content/10.110…
Check out our detailed protocol (+ some new data) for the nPOP droplet sample preparation method for multiplexed single cell proteomics. The current version is dramatically streamlined and simplified since the first instantiation! A thread 🧵 biorxiv.org/content/10.110…
We just shared a detailed protocol for highly parallel single-cell proteomics. It allows: ◼️Preparing simultaneously > 3,000 of cells ◼️Quantifying 3,000 - 3,700 proteins / human cell (< 5min). ◼️Counting O( 10⁷ ) peptide copies / cell. biorxiv.org/content/10.110…
Our new @Dev_journal article is up at journals.biologists.com/dev/article-ab… It provides an accessible introduction to single-cell mass spec proteomics methods and suggests initial questions in development that are ripe for investigation.
Want reliable quantities? Brilliant students in my lab @ZiskaKistner @JustusGrossmann figured out how. We present QuantUMS, an ML-based algorithm for step-change better quantitation in proteomics and statistical confidence in individual quantities biorxiv.org/content/10.110……
Since 2016, @slavovLab has been developing a single-cell proteomics approach that is tailored to biological objectives. This Research Briefing tells the story rdcu.be/c84yN The @naturemethods article: nature.com/articles/s4159… 1/2
Excellent start to April - latest paper now out! Glad to have contributed - our lab is now using this workflow to study viral PTMs at single-cell level!
Excellent start to April - latest paper now out! Glad to have contributed - our lab is now using this workflow to study viral PTMs at single-cell level!
Conflicting objectives are common, but satisfying them all less so. That is the objective of prioritized mass spec proteomics, now live at @naturemethods! pSCoPE simultaneously increases coverage, data completeness, flexibility (e.g., PTM analysis), and quantitative accuracy.
Conflicting objectives are common, but satisfying them all less so. That is the objective of prioritized mass spec proteomics, now live at @naturemethods! pSCoPE simultaneously increases coverage, data completeness, flexibility (e.g., PTM analysis), and quantitative accuracy. https://t.co/12mifsHext
“We should be using every tool at our disposal to advance breakthrough discoveries,” Griffin told Forbes. “And new research models can bring together the right teams and resources to drive progress in science and medicine that will impact lives..." forbes.com/sites/alexknap…
Today, we announce ParallelSq Technology Institute (PTI): @ParallelSqTech PTI will develop scalable proteomic technologies for exploring proteome biology at unprecedented scale and resolution. We will openly share tools & data to empower research🔓 parallelsq.org/blog/welcome
We launch to accelerate proteome biology research. We aim to uncover fundamental physiological and pathological mechanism by directly analyzing proteins at unprecedented scale and resolution. As a nonprofit FRO, we will openly share methods & data 🔓 parallelsq.org/blog/welcome
A milestone for a young field: Our community recommendations for single-cell proteomics are published OA in @naturemethods: nature.com/articles/s4159… 1/n
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Parallel Squared Tech... @ParallelSqTech
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Purvi Saxena @PurviSaxen26086
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Northeastern Universi... @NUBioE1
614 Followers 223 Following Official account of the Department of Bioengineering at Northeastern University.
Christophe Vanderaa @c_vanderaa
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1K Followers 942 Following Focus on developing workflows for mass spectrometry based biolomecule characterization and proteome profiling. 2 wheels + an engine = fun!
Nico Hüttmann @NicoHuettmann
77 Followers 390 Following PhD student in the Savitski Team @EMBL Heidelberg. Alum Berezovski lab and JLHMS facility @uOttawa, @TUDarmstadt. Handball and Tennis and more coming
Teresa Kim, MD @TeresaKimMD
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B Tenge @btenge89
276 Followers 4K Following IT Specialist; Analytical Chemist (Ph.D, ‘89, UW); Fan of Public Health; Fan of Machine Learning Methods/Chemometrics
Charlotte Hutchings @CharlH_Science
174 Followers 223 Following PhD scientist training in AAV gene therapy and proteomics in the Lilley lab🧪🧬❤️ Also a big fan of scuba diving, cooking and espresso martinis. (She/Her).
Shohreh @ShohrehVanaei
18 Followers 86 Following
Northeastern Universi... @NUCommLab
52 Followers 35 Following The Northeastern Comm Lab offers online workshops and peer-to-peer coaching for graduate-level writing and communication tasks for course work and research.
Consortium for Top-Do... @TopDownProteome
2K Followers 2K Following Collaboration, education, and innovative research accelerating the comprehensive analysis of all human proteoforms. https://t.co/BNhhb78Wdk https://t.co/pTAjgMwCEh
Tami Geiger (lab) @LabGeiger
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Jason Derks @_JasonDerks
252 Followers 310 Following Increasing throughput of proteomics @ParallelSqTech
Nick Drachman @ndrach1
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Kristina Ulicna 👩�... @KristinaUlicna
14K Followers 11K Following AIxBio Research Scientist 👩🔬 | PhD Comp Bio 👩💻 | BSc Biomed 🧫 | "Singlecellologist" 🦠 into biologically meaningful representation learning 🧬 | LDN 🇬🇧
Aleksandra Petelski @aleks_petelski
143 Followers 204 Following PhD Student excited about proteomics, ribosomes, and single cell analysis! Experimenting in the @slavovLab @NUBioE1 @ParallelSqTech
Michal Gregus @gregus_michal
46 Followers 134 Following Analytical Chemist. Research Scientist at Northeastern University. Slovak Expat in US.
Carolyn Lee-Parsons @CLeeParsons
118 Followers 125 Following Prof in Chemical Engineering, Chemistry & Chemical Biology, studying & engineering how plants regulate the production of their specialized metabolites
Muralidharan V @V_MuraleeDhar
77 Followers 238 Following Early career researcher interested in Mass Spectrometry, Proteomics, Natural products-based drug discovery, Snake Venom #massspectrometry # proteomics
Mohd Altaf Najar, Ph.... @MohammadAltafN3
438 Followers 2K Following Mass-spectrometry, proteomic, post translational modifications of proteins, signalling, lysine modifications, protein homeostasis
Slavov Laboratory @slavovLab
3K Followers 125 Following We seek principles in the coordination among protein synthesis, metabolism, cell growth and differentiation PI: @slavov_n Videos: https://t.co/tfkuZB7tgw
Fabian Theis @fabian_theis
35K Followers 426 Following Computational biologist @HelmholtzMunich, prof @TU_Muenchen & associate PI @sangerinstitute. Dad of 4 and mountain lover. Department news, see @CompHealthMuc
Science in Seattle @science_seattle
2K Followers 988 Following Your complete source for all the life science news and events in the Seattle area. Brought to you by the Science in the City program @STEMCELLTech.
Niko McCarty. @NikoMcCarty
37K Followers 1K Following Science. Biology. Progress. Founding Editor @AsimovPress / Subscribe!
Genome Biology @GenomeBiology
90K Followers 442 Following Tweets about latest articles in the journal Genome Biology, conferences & more. Part of @SpringerNature. Also read our blogs (https://t.co/7GgHTUIKaX).
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1K Followers 624 Following GI Medical Oncologist at MD Anderson Cancer Center. Opinions my own. Follow me on Instagram @gi.onc.doc
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416 Followers 371 Following Surgeon, scientist, OHSU | Family - Hepatopancreatobiliary cancer patients - Scientific discovery | T cells I https://t.co/bNHg1oCEC2
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