Stahelin Lab @Stahelin_Lab
Laboratory at Purdue University using biochemistry and biophysics to study lipids and viruses. Drug development against viral hemorrhagic fevers. U2 fans! West Lafayette, IN Joined April 2018-
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Candidates have been disclosed for the upcoming election for the American Society for Biochemistry and Molecular Biology. If you are an ASBMB member, don't forget to vote! #vote #asbmb #JLR #jbc asbmb.org/asbmb-today/pe…
New publication! It was a wonderful collaboration with the lab of Juan Del Valle at Notre Dame. This would not be possible without his team and their peptide design. A constrained peptide that binds the Ebola virus matrix protein #ebola #VP40 #peptide pubs.rsc.org/en/Content/Art…
I was very happy our work was chosen to the cover this month. Especially for former postdoc Souad Amiar and collaborator Andrea Marzi Cover - Journal of Lipid Research jlr.org/article/S0022-…
Check out our new preprint! biorxiv.org/content/10.110… We found sphingolipid binding to SARS-CoV-2 M protein controls its conformation to coordinate viral assembly+release. Great collaboration with @VothGroup + @Stahelin_Lab co-led by @KimDolan_UCB, Mandira Dutta, + @souadamiar.
Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly New preprint in collaboration with the @SteveBrohawn @VothGroup Excellent team effort demonstrating a ceramide-1-phosphate interaction in M! #membrane biorxiv.org/content/10.110…
Very pleased to announce a new review in Virology put together by Ph.D. student Rokaia Sultana. This article details the strenghts and limitations of virus-like particle systems for SARS-CoV-2 #virus #sarscov2 #lipid #virology sciencedirect.com/science/articl…
Fatty acids and membrane order matter for assembly and budding of the Ebola virus matrix protein VP40! New work from the lab. Big thanks to Andrea Marzi! #ebola #lipidtime #membrane #VP40 #plasma_membrane jlr.org/article/S0022-…
New collaborative work examining electrostatic interactions between the Ebola virus matrix protein VP40 and the plasma membrane at key arginine substitutions! pubs.acs.org/doi/10.1021/ac… #ebola #lipidtime #VP40 #membrane #filovirus
The N (nucleoprotein) interacts with anionic lipids including phosphoinositides and phosphatidylserine. New work from the lab and collaboration with the lab of Greg Voth. #lipidtime #sars2 #membrane jbc.org/article/S0021-…
Collaboration with Dr. Elsje Pienaar's computational lab yields a better understanding of the Ebola virus nucleoprotein's role in virus budding. #Ebola #nucleoprotein #VP40 nature.com/articles/s4200…
Collaboration with Dr. V. Jo Davisson's lab! New studies demonstrating potency and stability of diphyllin-derived Vacuolar-ATPase inhibitors #Virus #pH sciencedirect.com/science/articl…
Abstracts Due 5/26!🌟 Explore the latest in #Phospholipid Biology at #LSHSRC! Join Antonella De Matteis @Tigem_Telethon and @VolkerHaucke in July for "Phospholipids in Aging and Disease." Topics: lipid signaling, treatments for diabetes, cancer, & more. bit.ly/3xQj5yp
Abstracts Due 5/26!🌟 Explore the latest in #Phospholipid Biology at #LSHSRC! Join Antonella De Matteis @Tigem_Telethon and @VolkerHaucke in July for "Phospholipids in Aging and Disease." Topics: lipid signaling, treatments for diabetes, cancer, & more. bit.ly/3xQj5yp https://t.co/PW5co1TFJE
Learn more about how the Ebola virus matrix protein (VP40) dimer is stabilized! A wonderful collaboration with the Wiest and Chapagain labs integrating computational work with in vitro and cellular studies. #ebola #vp40 #lipidtime #Virus onlinelibrary.wiley.com/doi/full/10.10…
Happy this manuscript is published, especially for Ph.D. student Bali Motsa. Demonstrates how +1 or -1 in charge (and more) can alter lipid binding, assembly, and budding of the Ebola virus matrix protein VP40. jbc.org/article/S0021-… #ebola #lipidtime #electrostatics #VP40
New work from our collaboration with the lab of Dr. Elsje Pienaar at Purdue. A computational model of the Ebola virus matrix protein nucleation-elongation process! #ebola #lipidtime journals.asm.org/doi/10.1128/sp…
New work from the lab with integrated collaborative studies with Prem Chapagain's lab on the role of phosphatidic acid in assembly and budding of the Ebola virus. @AsbmbLrd #lipidtime #ebola #VP40 sciencedirect.com/science/articl…
We are happy to have a new preprint online! Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles biorxiv.org/content/10.110…
Excited to have this work published in the Journal of Lipid Research! How PI(4,5)P2 binding sites in the Ebola virus matrix protein modulate assembly and budding! KAJ the rockstar! @KristenAnnaJoh1 @jlipidres @AsbmbLrd #lipidtime jlr.org/article/S0022-…
It’s Dr. Emily David, Ph.D.! This degree was made possible by the incredible support from my family and friends, my mentor, @Stahelin_Lab and lab mates, @Purdue_MCMP dept., the @purduepharmacy, and @MbtpPurdue program. Boiler up! @LifeAtPurdue Photo by Chloe Smetanka
We had a wonderful week at Madeira! Thank you all for the great discussions at the FEBS Special Meeting on Sphingolipid Biology. It was a pleasure to host you all! #sphingolipidbiology #SLBiol2023 #visitmadeira @FEBSnews @EMBOevents @CoskunPLID @BassereauTeam @Stahelin_Lab

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