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Interested in adding a splash of water to your ligand discovery campaign? Check out our latest article: nature.com/articles/s4159…
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A GUI that seamlessly integrates FLEXR electron density based multi-conformer model building into Coot1's modeling and validation tools. journals.iucr.org/j/issues/2024/…
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Exemplifies the power of collaboration at @StJudeResearch by CBT Chemistry Centers, @KlcoLab and @TheFischerLab funded by @AlexsLemonade. nature.com/articles/s4146…
The opus magnum of our PhD student Fatemeh, now @KymeraTx, is out in @BloodJournal in collaboration with the @CMullighan lab: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia. ashpublications.org/blood/article-…
TheFischerLab retweeted
We're at it again, but even better! Please join us virtually or in person at St. Jude for 2023 Bringing Chemistry to Medicine! @StJudeResearch bit.ly/BC2M_2023
TheFischerLab retweeted
Like comparing apples to apples, comparing similar proteins can be challenging. Scientists in @TheFischerLab developed a tool to help, which garnered new insights into the chaperone protein HSP90—an essential target in cancer. Read about their work. bit.ly/3LMhQVf
TheFischerLab retweeted
FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing conformations in ligand-binding sites that were undetected using other methods. #CrystallographicRefinement #ModelBuilding doi.org/10.1107/S20597…
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B doi.org/10.7554/eLife.…
TheFischerLab retweeted
Interested in water in ligand binding sites? Our newest paper applies RE-EDS to study the thermodynamics of water networks in protein cavities. pubs.acs.org/doi/10.1021/ac…
TheFischerLab retweeted
New research from @TheFischerLab published in the Journal of Medicinal Chemistry has revealed distinct targetable hotspots on #HSP90, an important target in cancer. bit.ly/3SRxpwt @ACSBioMed
Thrilled to see @TheFischerLab's latest work on how "Water Networks Repopulate Protein-Ligand Interfaces With Temperature" out in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…
Excited to see our collaborative work on the “Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia” appear as a Plenary Paper in @BloodJournal with @CMullighan and #stjuderesearch CBT Chemistry Centers. authors.elsevier.com/a/1eDN%7E1UYwb…
What's under your mask? Happy #Movember2021! Support here: movember.com/m/mogul123?mc=1 Join here: movember.com/t/memstache?mc…
TheFischerLab retweeted
The Nabet lab @fredhutch is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in developing targeted protein degradation technologies and advancing proximity-induced therapeutic strategies? Please RT & apply here: careers-fhcrc.icims.com/jobs/20699/pos…
Phenyl-Glutarimides improve PROTAC stability. Another great collaboration with the CBT ChemistryCenters @StJudeResearch and @TheFischerLab (and many others) just appeared in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…
Postdoc position in computational structural biology in @TheFischerLab available right now! Please re-tweet :)
Postdoc position in computational structural biology in @TheFischerLab available right now! Please re-tweet :)
TheFischerLab retweeted
Expanding the chemical toolbox for bromodomain PHD finger transcription factor BPTF in a fun whirlwind collaboration with @fewill26 and @TheFischerLab. pubs.acs.org/doi/10.1021/ac…
Thanks to RSC @ChemistryWorld for a *cool* feature of our recent @ChemicalScience article pubs.rsc.org/en/content/art…
Thanks to RSC @ChemistryWorld for a *cool* feature of our recent @ChemicalScience article pubs.rsc.org/en/content/art…
TheFischerLab retweeted
🎉 Issue 34 is here! 🎉 Marcus Fischer (@TheFischerLab) et al.'s recent #ChemSciPicks article is featured on the front cover 😍 Read it here ➡️ Temperature artifacts in protein structures bias ligand-binding predictions 🔗 ow.ly/htjA50G2PSZ 📍 @UCIrvine | @StJudeResearch
St. Jude Research @StJudeResearch
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Kresten Lindorff-Lars... @LindorffLarsen
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John Chodera (he/him) @jchodera
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Gabriel Rocklin @grocklin
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Dan Nomura @DanNomura
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Ryan Potts @pottslab
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Olalla Vázquez @OlallaLab
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Milka Kostić, PhD @MilkaKostic
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Vajja Krishna Rao @VKRMedChem
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Chase @Chase22555361
194 Followers 492 Following SMC, CWRU, UCSF, Columbia. My views are my own. Into rock climbing, basketball, chemistry, opioids, and GPCRs.
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Lucas Souza @lucassansouza
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Matthew Bowler @moncourvoisier
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Faten Okda @OkdaFaten
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Hsp90 Chaperone Machi... @Hsp90Machine
438 Followers 177 Following
Brittany Pioso @brittpioso
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neet @neet9898
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Some_guy @Herr_Flow
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Baharul Islam, Ph.D. @DrBee_9
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Istaq Ahmad @istaqahmad
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Ilona Jóźwik @IlonaJozwik
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Iva Marković @MarkovichIva
87 Followers 271 Following 💎 Structural biology 🛠 Protein engineering 🟠 Cytokines Postdoc @SavvidesLab, @InflamResCen & @UGent || @VIBLifeSciences
Mohit @mohitasya
446 Followers 1K Following Team Leader @iDikic2 lab @Proxidrugs Ubiquitin enthusiast with expertise in structural biology
BenCree @ChemCree
264 Followers 1K Following Postdoc @RIKEN, PhD from @ColegroupNCL Newcastle University. Computational Chemist/Drug Design & Open Source Dev. Fan of SC2. An English flavoured scientist.
M. A. Shehata @MoSjeDK
218 Followers 26 Following
Sthitadhi Maiti @sthitadhi_m
317 Followers 3K Following Truthseeker, Chemistry Ph.D student at Arizona State University
Shantanu Shukla, Ph.D @shaanbdu
149 Followers 763 Following Postdoctoral fellow at Fred Hutchinson Cancer Center . Structure and dynamics of bacterial and viral proteins and their molecular function. Views are my own.
Cowen Lab @CowenLab
2K Followers 640 Following Research team at the University of Toronto working to better understand fungal pathogens and how to treat them! Account managed by @NM_Robbins
Carrie Crunk @Carrie_CrunkSJ
4 Followers 28 Following Providing support to the postdoctoral fellows at St. Jude Children's Research Hospital
Hannah Snoke @SnokeHannah
20 Followers 68 Following
van Oosten-Hawle lab @HawleLab
691 Followers 556 Following Twitter feed of the van Oosten-Hawle lab Assistant Professor @unccharlotte
Agard Lab @AgardLab
804 Followers 71 Following Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members
Kiran T. Patil @KiranPatil98
36 Followers 589 Following M.Pharm in Pharmaceutical(Medicinal) Chemistry @cup_bathinda 🇮🇳 | Pharmacist
BioBRU Lab @Bio_BRU
338 Followers 787 Following Official Twitter account of Edkins lab and the Biomedical and Biotechnology Research Unit (BioBRU) at Rhodes University, RSA. Views personal not Rhodes Uni.
Kasia Tych @BiophysK
2K Followers 4K Following Single molecule biophysicist, Tenure track assist. prof. at the University of Groningen. Enjoys food, bouldering, silliness & science. @biophysk.bsky.social
Anthony Harrison @antmarkharrison
150 Followers 113 Following Director of The Collaborative Library, Clinical Psychologist in Bradford, Teaching Fellow at King's College. Varied research interests. All views my own.
Ogunsola Oluwatosin @Ogunsolatosin_1
109 Followers 940 Following Lover of God|Mother|Biochemist|Data Analyst|Data Scientist| Drug Discovery enthusiast| Fellow, Women in Artificial Intelligence
Sara J. Weaver, Ph.D. @sarajweaver
1K Followers 2K Following Structural biologist in pharma. Post doc @GonenLab @UCLA. PhD @theJensenLab @Caltech. https://t.co/KqIWKvaWLd
MariaGiovannaEva @MGEPapadopoulos
29 Followers 126 Following
St. Jude Graduate Sch... @stjudegraduate
876 Followers 178 Following #StJude Graduate School of Biomedical Sciences: leading-edge science, unparalleled resources & unique clinical experiences for the next generation of scientists
Gabriele D'Uva @gabrieleduva
349 Followers 923 Following Researcher in #HeartRegeneration, #Cardiotoxicity and #Cancer. Professor of Molecular Biology at University of Bologna/IRCCS Sant'Orsola. President of RIE.
Siyawaka @siyawaka_handz
197 Followers 1K Following
St. Jude Research @StJudeResearch
33K Followers 2K Following St. Jude Children’s Research Hospital: a leader in research & treatment of pediatric cancer & childhood diseases. #BestHospitals #StJudeResearch
Kresten Lindorff-Lars... @LindorffLarsen
14K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰
John Chodera (he/him) @jchodera
9K Followers 7K Following Changing drug discovery one ratio of partition functions at a time. Heading up antiviral discovery for pandemics: https://t.co/uN4XpX1mjt https://t.co/YAg9PBYuBl
Structural Biology at... @StJudeStructBio
2K Followers 13 Following Dept. of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch
Craig Crews @CraigMCrews
9K Followers 951 Following Yale Professor, Founder of @ArvinasInc, Halda Therapeutics, https://t.co/YoR6Yo3d3u, @[email protected]
Gabriel Rocklin @grocklin
3K Followers 595 Following High-throughput protein design and biophysics | Asst Prof, Northwestern Pharmacology @NuFeinbergMed @NUSynBio.
Jen Heemstra @jenheemstra
94K Followers 13K Following Professor and Chair of @WashUChem, proud member of @HeemstraLab. I'm a researcher, but I'm a #MentorFirst. Author of Labwork to Leadership.
Keith Hornberger @KRHornberger
12K Followers 260 Following TPD-med chem-hiking-cocktails / while I have a connection to Arvinas, all opinions expressed are mine and do not represent the views or positions of the company
Practical_Fragments @PracticalFrag
1K Followers 13 Following A blog founded by Teddy Zartler and run by Dan Erlanson for Fragment-based Drug Discovery devotees to discuss non-confidential issues regarding fragments.
Kriwacki Lab @kriwacki
1K Followers 116 Following The Kriwacki lab seeks to understand the role of conformational disorder in protein function. Account run by lab members. @StJudeStructBio
JK Lyu @Jiankun_Lyu_
464 Followers 566 Following Assistant professor @RockefellerUniv, former postdoc in @BShoichet lab @UCSF.
Tamir Gonen @gonenlab
6K Followers 463 Following Drug discovery; chemistry; Biophysics; Membrane proteins; #cryoEM; crystallography; #MicroED; Opinions my own. 👋👋👋
HalicLab @LabHalic
702 Followers 257 Following Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio
London Lab @london_lab
4K Followers 670 Following A computational and chemical biology lab at the Weizmann Institute of Science.
Ryan Potts @pottslab
2K Followers 357 Following VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
Jay Bradner, M.D. @jaybradner
23K Followers 906 Following Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen
The Roberts Lab @TheRobertsLab1
1K Followers 249 Following The lab of Charlie Roberts at @stjuderesearch studying SWI/SNF chromatin remodeling complex. Tweets are from lab members unless signed CR.
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
Mehdi Mollapour PhD @MedMol
598 Followers 320 Following Professor of Urology, Biochemistry & Molecular Biology | Upstate Medical University
Stuart Schreiber @SchreiberStuart
12K Followers 370 Following Truth-seeking scientist; equal parts Cajun, Mississippian, Irish, Hungarian.
Stefan Gahbauer @GahbauerStefan
257 Followers 271 Following Principal Scientist | Deep Apple Therapeutics | #CompChem | #CompBio | Drug Discovery | Docking | Molecular Dynamics | GPCRs
Doug Kojetin @DougKojetin
1K Followers 3K Following Structural biologist & molecular pharmacologist | #nuclearreceptors | #NMR | @VanderbiltU @VUBasicSciences @VandyBiochem @VanderbiltCSB | same handle on 🦋
The Klco Lab @KlcoLab
268 Followers 230 Following The Klco lab at @stjuderesearch - Defining the molecular and biological causes of pediatric myeloid tumors
Chia-Hsueh Lee @TheCHLeeLab
583 Followers 339 Following Associate Member, Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio
Richard @Richard_E_Lee
566 Followers 878 Following A medicinal chemist with a passion for antibacterial drug discovery. My thoughts are my own.
Roland Dunbrack 🏳�... @RolandDunbrack
4K Followers 2K Following Comp struct bio. Gay&proud 🏳️🌈. Views my own & not my employer's.
Johannes Morstein @mo_hannes
1K Followers 1K Following Assistant Professor @CaltechCCE | Chemical Biologist
Matthew Bowler @moncourvoisier
696 Followers 1K Following 🇪🇺 🇬🇧 🇺🇸 🇫🇷 scientist, project leader @EMBL @esrfsynchrotron #beamline @ID30_MASSIF1 #kinases #pathogens co-editor 📓 @ActaCrystF opinions my own
Christina Wang @cewang35
195 Followers 121 Following PhD candidate in the @Ogden_Lab at @stjudegraduate | Vandy ‘19| Views are my own
Kate Stafford @kastacholamine
2K Followers 3K Following AI/ML for proteins, small molecules, and everything in between. Scientist @AtomwiseInc. (she/her) 🌈 Previously: UCSF, Columbia, DE Shaw Research, MIT.
Zuzanna Kozicka @zkozicka
664 Followers 508 Following Postdoc @DFCI @HarvardMed @BroadInstitute, previously PhD @LabThoma, Forbes 30U30 Science&Technology 2023, @EdinburghChem graduate (she/her)
Shantanu Shukla, Ph.D @shaanbdu
149 Followers 763 Following Postdoctoral fellow at Fred Hutchinson Cancer Center . Structure and dynamics of bacterial and viral proteins and their molecular function. Views are my own.
Cowen Lab @CowenLab
2K Followers 640 Following Research team at the University of Toronto working to better understand fungal pathogens and how to treat them! Account managed by @NM_Robbins
Matthew O’Meara @momeara
798 Followers 3K Following Assistant professor at UMich with a focus on computational pharmacology. (he/him)
M. A. Shehata @MoSjeDK
218 Followers 26 Following
Will Pomerantz @Fe_Will26
477 Followers 303 Following Prof. of Chemistry at UMN, Fluorophile, epigenetics afficiando, coffee geek, and proud dad
Riniker lab @ ETHZ @rinikerlab
930 Followers 30 Following
BioBRU Lab @Bio_BRU
338 Followers 787 Following Official Twitter account of Edkins lab and the Biomedical and Biotechnology Research Unit (BioBRU) at Rhodes University, RSA. Views personal not Rhodes Uni.
Kasia Tych @BiophysK
2K Followers 4K Following Single molecule biophysicist, Tenure track assist. prof. at the University of Groningen. Enjoys food, bouldering, silliness & science. @biophysk.bsky.social
Agard Lab @AgardLab
804 Followers 71 Following Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members
van Oosten-Hawle lab @HawleLab
691 Followers 556 Following Twitter feed of the van Oosten-Hawle lab Assistant Professor @unccharlotte
Ranok Therapeutics @RanokTx
333 Followers 115 Following Ranok is pioneering Chaperone-mediated Protein Degradation (CHAMP) technology to treat cancer. #proteindegradation
Understanding Life in... @AstburyCentre
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Nature Chemistry @NatureChemistry
273K Followers 1K Following A chemistry journal from @NaturePortfolio & @SpringerNature.
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192 Followers 493 Following Senior Publishing Editor at the Royal Society of Chemistry. @SheffieldChem alumnus. All views my own.
William L. Jorgensen @JorgensenWL
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Rommie Amaro @RommieAmaro
8K Followers 953 Following Professor @UCSanDiego. Computational chemist & biophysicist, multiscale modeler. Viruses. Cancer. Unapologetically molecular.
SunLab @JiSunLab
659 Followers 310 Following The Sun Lab | Dept. of Biological Science @ National University of Singapore
André Richters @AndreRichters
108 Followers 146 Following Scientist | Chemical Biology | Cancer Research | Drug Discovery | Targeted Degradation Strategies | Spartan Race Enthusiast
The Colombo Lab @lab_colombo
2K Followers 2K Following Giorgio Colombo's Computational Chemistry and Biology Lab; Always Room for Improvement; University of Pavia, Italy. @lab-colombo.bsky.social
Paul Robustelli @PaulRobustelli
3K Followers 1K Following Assistant Professor at Dartmouth College Computational Biophysics / Disordered Proteins / Molecular Recognition
Structural Biology @ActaCrystD
3K Followers 421 Following Acta Crystallographica Section D: Structural Biology is a leading structural biology journal published by the IUCr.
hai dao @ongnghiem
270 Followers 321 Following Assistant Member, St. Jude Faculty/Chemist, Chromatin Biochemist
Behnam Nabet @behnamnabet
1K Followers 536 Following Assistant Professor @fredhutch | dTAG designer | Proud Husband & Baba | He/Him/His
Dorothee Kern @DorotheeKern
1K Followers 78 Following Professor at Brandeis University and HHMI. Using biophysical techniques to unravel the dynamic personality of proteins and study their evolution.
Debora Marks @deboramarks
4K Followers 189 Following Mission: design of biological interventions for environment and human health (to save the world)
Simon Olsson @smnlssn
2K Followers 1K Following Associate Professor at @chalmersuniv. @WASP_Research Fellow. ELLIS Member.
Phil Biggin 🇪🇺 @philbiggin
2K Followers 409 Following Computational biochemist, interested in neuronal signalling at the atomic level and computer-aided drug design. All views my own. @[email protected]
Inês Chen @Ineschen0
391 Followers 86 Following Director of Scientific & Strategic Operations Department of Structural Biology St. Jude Children's Research Hospital @StJudeStructBio Opinions my own.
Björn Rissiek @BjrnRissiek
159 Followers 409 Following Father of one, likes neuroimmunology, T cells, purinergic signalling, nanobodies, fly fishing and electric guitars. My opinion are my own.
Angewandte Chemie @angew_chem
111K Followers 3K Following Angewandte Chemie, a journal of the German Chemical Society (GDCh, @GDCh_aktuell) - a leading journal in #chemistry published by @WileyVCH in @Weinheim
ProfG @ProfG101
2K Followers 278 Following Professor at the University of York; workwise interested in enzymes, carbohydrate & chemical biology. I have stopped tweeting now. Views are my own.Trends for United States
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