The paper in @CircIntv describes how the @CHIP_BCIS3 trial uses novel methodology to optimise the chances of finding a definitive answer to this important clinical question: does elective LV unloading during high-risk PCI reduce major adverse CV events? bit.ly/4bV3VHu
The paper in @CircIntv describes how the @CHIP_BCIS3 trial uses novel methodology to optimise the chances of finding a definitive answer to this important clinical question: does elective LV unloading during high-risk PCI reduce major adverse CV events? bit.ly/4bV3VHu
1. It uses a hierarchical composite outcome that ranks clinical events in order of importance to the patient. 2. The incidence of this hierarchy in each patient assigned to LV unloading will be compared with every patient in the standard of care arm using a #WinRatio
3. Periprocedural MI (ppMI) only considered if “more important” clinical outcomes have not occurred in pairwise comparison. 4. ppMI definition specific to pre-procedure values and trends. #WinRatio comparison considers size of infarct. @CTU_LSHTM @DrMattRyan @divaka_perera