Yi Sun @YiSun1212

Joined October 2022

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Stanford Bioengineering @bioe_stanford

a year ago

In @bioe_stanford’s Professor Possu Huang’s lab, Haotian Du is engineering novel proteins which could enhance our ability to detect more cancer types.@PossuHuangLab

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SgourakisLab @SgourakisLab

2 years ago

Congratulations @PossuHuangLab! Such a versatile platform!

Possu Huang Lab @PossuHuangLab

2 years ago

Congratulations @PossuHuangLab! Such a versatile platform!

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Deciding which patients can receive #CAR T therapy is an important clinical question. By uncovering the structural basis of #MHC antigen recognition by a #neuroblastoma-targeting CAR we double the patient cohort and limit off-target toxicity @SciImmunology science.org/doi/10.1126/sc…

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SgourakisLab @SgourakisLab

2 years ago

By solving the crystal structure of the 10LH-PHOX2B-HLA-A*24:02-β2m complex, we identify critical interactions b/w the CAR + pHLA & validate them w/ alanine scanning + SPR binding studies. The key residues are the peptide P6 arginine & framework residues along the HLA α1 helix.

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SgourakisLab @SgourakisLab

2 years ago

.@YiSun1212 attended the @CancerGrand #NexTGen conference and presented a poster on our latest work – structure-guided therapeutic expansion of a peptide-centric #CAR. Great opportunity to explore new research from different labs!

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SgourakisLab @SgourakisLab

2 years ago

.@YiSun1212 attended the 37th #Gibbs Conference in Carbondale. It was a great opportunity to present our work on #MHC/#TAPBPR #xeno interaction and tell the story of using biophysical tools to solve immunological problems!