Institute for Protein Design @UWproteindesign
We create proteins that solve challenges in medicine, technology & sustainability // Co-developers of @Foldit // @UWMedicine | https://t.co/1PR2DtKdeB ipd.uw.edu Seattle, WA Joined September 2013-
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“I believe this collaboration between a stem cell institute, a dental school, and experts in genetic sequencing and protein design could only happen in a few places, and one of them is in Seattle.” @UWDentalSchool @RuoholaL @UWproteindesign @BrotmanBaty bit.ly/4aIfBMT
Register today for this free @SynBioBeta event: synbiobeta.zoom.us/webinar/regist…
We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
We’re really happy to share our preprint demonstrating the atomically-accurate design of single-domain antibodies (VHHs) with RFdiffusion!
Structure-based VHH design preprint is now up! @naterbennett0 @_JosephWatson @RobertRagotte @andrewjborst and special shoutout to @dejsee and Buwei who I collaborated with on this study. Watch this space closely, there's more coming :) @UWproteindesign biorxiv.org/content/10.110…
Super excited to finally see the publication of this great paper in @Nature; this was one of the first projects I got to work on in grad school! Home Depot inspired #ProteinDesign @UWproteindesign Work led by @tim_huddy @kribler Yang and @xu_jinwei nature.com/articles/s4158…
📈 Read one of our recent most read #OpenAccess articles, "Improving Protein Expression, Stability, and Function with ProteinMPNN" @BilbaoChem @UWproteindesign @CICbioGUNE @brta_eus @Ikerbasque Read the article here ➡️ go.acs.org/7Kk
Our director David Baker recently shared his thoughts on the impact of AI on life sciences and healthcare startups. He spoke with Jenny Cronin at a @UWCoMotion event. ipd.uw.edu/2024/03/david-…
With transformer #AI protein design and major advances in DNA synthesis, how do we deal with biosecurity concerns? Editorial @ScienceMagazine science.org/doi/10.1126/sc… David Baker @UWproteindesign and @geochurch
Protein design pioneer David Baker on why sharing code is key to building biotech startups. @UWproteindesign @schubertcm @geekwire bit.ly/49LEyGD
Paper is now live on @ScienceMagazine! Congrats to @r_krishna3 @jueseph @woodyahern for leading this work. Big leap for protein modeling and design! Paper: science.org/doi/10.1126/sc… Code: github.com/baker-laborato…
Paper is now live on @ScienceMagazine! Congrats to @r_krishna3 @jueseph @woodyahern for leading this work. Big leap for protein modeling and design! Paper: science.org/doi/10.1126/sc… Code: github.com/baker-laborato…
Protein binding a small molecule designed with RFDiffusion-AA yesterday. I'm such a huge fangirl for these all-atom models. Baker Lab is awesome!
Signed. A good idea for safety in protein design (AI powered or not): regulate and control the protein synthesis machines and firmware, not the AI research itself. This is an idea I promoted at the UK AI Safety Summit.
Signed. A good idea for safety in protein design (AI powered or not): regulate and control the protein synthesis machines and firmware, not the AI research itself. This is an idea I promoted at the UK AI Safety Summit.
Scientists are getting ahead of potential downsides of #AI for protein design. There are so many compelling and important uses for new #proteins #enzymes. nytimes.com/2024/03/08/tec…
Our work on modeling and designing biomolecular assemblies is now in @ScienceMagazine. science.org/doi/10.1126/sc… RFAA Code: github.com/baker-laborato… RFdiffusionAA Code: github.com/baker-laborato…
Sergey Ovchinnikov �.. @sokrypton
12K Followers 3K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist
Kevin K. Yang 楊凱�.. @KevinKaichuang
16K Followers 5K Following Senior Researcher in BioML @MSFTResearch (@MSRNE). He/him/他. 🇹🇼
Kresten Lindorff-Lars.. @LindorffLarsen
13K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰 Same usr @ 🦋
Noelia Ferruz @ferruz_noelia
4K Followers 599 Following Group leader at @IBMB_CSIC in Barcelona. On a mission to speak the protein language fluently 💂♂️🫡
Brady Johnston @bradyajohnston
15K Followers 2K Following structural biologist, scientific animator, creator of #MolecularNodes, he/him #rstats #b3d mstd: [email protected] bsky: @bradyajohnston.bsky.social
Joseph Watson @_JosephWatson
3K Followers 108 Following Co-Founder @ Xaira Therapeutics Former Baker Lab PostDoc at @UWproteindesign. Interested in generative modelling for molecular design. Views my own.
David Juergens @DaveJuergens
2K Followers 2K Following Machine learning for molecular design. PhD student @UWMolES @UWproteindesign. B.S. @UWChemE
rcsb pdb 💉🧬💻.. @buildmodels
14K Followers 473 Following RCSB PDB promotes a structural view of biology. Funded by @NSF, @thenci, @NIAIDNews, @NIGMS, @NIH, & @doescience. Contact [email protected] with service questions.
Protein Data Bank @PDBeurope
22K Followers 872 Following PDBe is a founding member of the wwPDB. The PDBe team is also responsible for the PDBe-KB, AlphaFold DB and 3D Beacons resources.
Sjors Scheres @SjorsScheres
15K Followers 660 Following Joint Head of Struct. Studies @MRC_LMB #RELION, #cryoEM, #amyloids, #OpenScience All opinions my own. Same name on https://t.co/7ZvFwboaIY and https://t.co/DCRukHhSh7
Michael C. Jewett @MichaelCJewett
7K Followers 483 Following Professor of Bioengineering, Stanford University
Gabriel Rocklin @grocklin
2K Followers 537 Following High-throughput protein design and biophysics | Asst Prof, Northwestern Pharmacology @NuFeinbergMed @NUSynBio. Former @UCSF, @UWproteindesign
Patrick Hsu @pdhsu
30K Followers 3K Following co-founder @ArcInstitute, @BerkeleyBioE professor | researcher & investor in genome editing, biotech, AI | 🇨🇦 @harvard @broadinstitute @editasmed, Fast Grants
Jeffrey J. Gray @jeffreyjgray
4K Followers 1K Following @JHU_ChemBE Professor, Director of @RosettaCommons, protein engineer, Baltimore resident, father of two. he/him @jeffreyjgray.bsky.social
Machine learning for .. @ml4proteins
6K Followers 103 Following Seminar series on machine learning for protein engineering. Details for seminars and slack are on our website. DM us if you're interested in presenting!
Structura Biotechnolo.. @structurabio
5K Followers 449 Following Algorithms, Software and Systems for Cryo-EM. Makers of CryoSPARC.
ShorterLab @ShorterLab
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Basile Wicky @BasileWicky
1K Followers 451 Following Protein design & synthetic biology • Incoming asst. prof. @ETH_BSSE • Currently post-doc Baker lab @UWproteindesign
Nature Chemical Biolo.. @nchembio
24K Followers 629 Following A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
Kevin Litchfield @kevlitchfield
1K Followers 2K Following Research Leader @IsomorphicLabs and honorary Group Leader at UCL Cancer Institute
Kevin Yu @ykevu_
7 Followers 93 Following
Haixun Wang @haixunwang
241 Followers 353 Following VP Engineering & Distinguished Scientist @ Instacart, ex Amazon, Facebook, Google, Microsoft, IBM
Nicole Gull @nicoleversetwo
159 Followers 315 Following Bioinformatics, DNA Methylation, Cancer Genetics, Sailing, Hiking, Nerding
Abhinav Gupta @backpropper
796 Followers 5K Following phd student @Mila_Quebec | ms @CILVRatNYU @NYU_Courant | previously @GoogleDeepMind @AIatMeta @GoogleAI @labsdotgoogle @MSFTResearch @AdobeResearch
Bimal Desai @bimald
2K Followers 3K Following Assoc Prof. Dept of Pharmacology, UVASOM. All views personal | I study ion channels in immunity & tissue homeostasis. RT and Likes may not be endorsements.
lenatschki @lenatschki
47 Followers 299 Following
damiano cianferoni @damianocianfe
1 Followers 67 Following Biomolecular design aficionado, with a penchant for computation.
Mathieu Alain @miniapeur
19K Followers 2K Following Researching @ai_ucl. Co-organises @uclcsml and @logconference. FR, EN, trying ES. 🇹🇼🇨🇦🇬🇳🇺🇸🇩🇴🇫🇷🇪🇸🇬🇧🇿🇦
Kks @Kks99049980
3 Followers 11 Following
Faiza Ashraf @FaizaAshraf903
11 Followers 123 Following #Don't run after the one who tries to avoid you.😊😊
Liza Chernova @eliza_chernova
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Krzysztof Potempa @BRAINCURES
3K Followers 5K Following Founder & CEO @BRAINCURESLtd and dreamster dedicated to prevention and treatment of mental health disorders that affect at least 1 in 6 people worldwide
ez @ez6456909858323
3 Followers 678 Following
Curtis Szmania @CurtisSzmania
173 Followers 474 Following Founder & CEO @CytoCyncBiz | Introducing Productized Health Software Services
Said SALHI @salhiSAId9
311 Followers 5K Following
MG @gaur_gaur3
38 Followers 662 Following MS,IITR 🇮🇳 Exploring biological intricacies. Stargazing and admiring sunsets otherwise
Wunna Kyaw @wunniess
61 Followers 223 Following PhD Student, Computational Biology, 'Omics, Biophysics, Imaging
Inge Kühl @IngeKuhl
284 Followers 317 Following Scientist, into mitochondria & everything related; Group leader #CNRS @I2BCParisSaclay #UnivParisSaclay
Chao Cui @ChaoCui761605
9 Followers 60 Following
Muhtashim Shafin @itsshafin91
100 Followers 463 Following I’m a young Genetic Engineer ,Geneticist,Researcher and a responsible citizen . Love,respect and integrity are my world.💖 https://t.co/6ZpKWByPcz
Alireza Noroozi @Alireza_N0roozi
14 Followers 53 Following
Ouranios @OuraniosK98
26 Followers 124 Following
Roberto Sanhueza @rsanhuezaaballe
0 Followers 8 Following
E.Fazelpour @EFazelpour
7 Followers 151 Following PhD in Computational chemistry, Oklahoma State University
Shafi Azam @shafaz_micro
388 Followers 2K Following Postdoctoral Scholar, University of Chicago. I study protein secretion and localization in Staphylococcus aureus
Jafar Ali @phantom_jj80
23 Followers 347 Following
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Wanwan Feng @oner25867756
52 Followers 376 Following Computational Biology, spatial-temporal transcriptomics，GNN, Transformer，Pretraining
Jarin Tasnim @Jarin_Tasnim71
38 Followers 926 Following Wanderlust, Creative and Curious👀 #PhD student of Molecular Biology #CancerBiologyResearch
serge-andre @sergeandre_
9 Followers 161 Following
cancelself @cancelself
0 Followers 717 Following += nothing to add, -= nothing to delete, := nothing is complete.
UkraineForGoodPeople @UkraineVSterror
500 Followers 3K Following
Dimitar Pachov @dpachov
223 Followers 274 Following Physics. Some serious things - science @Stanford | co-founder @Matternet | ... Now enjoying @Roche. Twitter is a personal game. Only my (unserious) rules apply.
Avezov lab @AvezovL
2K Followers 1K Following Based in @UKDRI @Cambridge_Uni, study neuronal cell biology, ER structure function by: Superresolution, Single particle tracking FP/Chem probes #lab_videoRxiv
Ada Fang @AdaFang_
150 Followers 101 Following PhD Student @harvardccb | Geometric ML and Chemistry @marinkazitnik lab | @KempnerInst graduate research fellow
Dr. Biswapriya Misra @BiswapriyaMisra
6K Followers 3K Following BiOmician #Delhite #Omics #Metabolomics #LCMS #Drugs |Alumni: @IITKgp @ETH_en @USMOfficial1969 @UF @txbiomed @wakehealthHM|
Santy Gegenschatz @santygegen
505 Followers 1K Following Research Scientist & Software Engineer | Studied @Udesa | Ex @Google
Salomé Llabrés Prat @s_llabres
135 Followers 917 Following
3DSIG @3DSIG_ISCB
164 Followers 134 Following 💻 We are the Structural Bioinformatics and Computational Biology track of the International Society for Computational Biology (ISCB) @iscb
Sergey Ovchinnikov �.. @sokrypton
12K Followers 3K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist
David R. Liu @davidrliu
64K Followers 59 Following Professor at Harvard, Broad Institute, & HHMI. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Kresten Lindorff-Lars.. @LindorffLarsen
13K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰 Same usr @ 🦋
Joseph Watson @_JosephWatson
3K Followers 108 Following Co-Founder @ Xaira Therapeutics Former Baker Lab PostDoc at @UWproteindesign. Interested in generative modelling for molecular design. Views my own.
David Juergens @DaveJuergens
2K Followers 2K Following Machine learning for molecular design. PhD student @UWMolES @UWproteindesign. B.S. @UWChemE
rcsb pdb 💉🧬💻.. @buildmodels
14K Followers 473 Following RCSB PDB promotes a structural view of biology. Funded by @NSF, @thenci, @NIAIDNews, @NIGMS, @NIH, & @doescience. Contact [email protected] with service questions.
Protein Data Bank @PDBeurope
22K Followers 872 Following PDBe is a founding member of the wwPDB. The PDBe team is also responsible for the PDBe-KB, AlphaFold DB and 3D Beacons resources.
Michael C. Jewett @MichaelCJewett
7K Followers 483 Following Professor of Bioengineering, Stanford University
Gabriel Rocklin @grocklin
2K Followers 537 Following High-throughput protein design and biophysics | Asst Prof, Northwestern Pharmacology @NuFeinbergMed @NUSynBio. Former @UCSF, @UWproteindesign
Jeffrey J. Gray @jeffreyjgray
4K Followers 1K Following @JHU_ChemBE Professor, Director of @RosettaCommons, protein engineer, Baltimore resident, father of two. he/him @jeffreyjgray.bsky.social
Tamir Gonen 🎗️ @gonenlab
6K Followers 526 Following Professor @UCLA School of Medicine @HHMINEWS Investigator; Membrane proteins; #cryoEM; crystallography; #MicroED; #firstgen; Opinions my own. 👋👋👋🎗️
Tom Ellis @ProfTomEllis
23K Followers 602 Following Synthetic Biology & Synthetic Genomics @ Imperial College London and the Sanger Institute. Bilingual in English and DNA. Also at https://t.co/f2Na2PES8R
Basile Wicky @BasileWicky
1K Followers 451 Following Protein design & synthetic biology • Incoming asst. prof. @ETH_BSSE • Currently post-doc Baker lab @UWproteindesign
David S. Goodsell �.. @dsgoodsell
26K Followers 115 Following ~molecular art | molecular science~ free digital files of my paintings at RCSB PDB: https://t.co/gJwOxh1GXU…
James Fraser (A$AP J) @fraser_lab
7K Followers 1K Following Professor and Chair @UCSF/@UCSF_BTS, VP @ASAPbio_ - dynamic structural biology and open science - (he/him)
Roland Dunbrack 🏳�.. @RolandDunbrack
3K Followers 2K Following Computational structural biologist at the Fox Chase Cancer Center. Out and proud. Pronouns: he, his, him. Living with CLL/SLL. @rolanddunbrack.bsky.social
Ellen Zhong @ZhongingAlong
7K Followers 901 Following Assistant Professor @PrincetonCS. #proteins247 #ml #cryoem #compbio #cryodrgn ❄️🐉#ai4science Prev: @MIT @DeepMind @DEShawResearch
Martin Steinegger �.. @thesteinegger
6K Followers 672 Following Developing data intensive computational methods • PI @ Seoul National University 🇰🇷 • #FirstGen • he/him • Hauptschüler • @[email protected]
Liz Kellogg ❄️�.. @kellogg_liz
4K Followers 1K Following Assoc. Member @St Jude Structural Biology, Pew Biomed. Scholar 2021, Margaret Dayhoff Oakley Awardee 2023, Co-host of #ThePlungePodcast w/@mcianfro & @mimi1inh
Rick Bright @RickABright
47K Followers 3K Following Practical, Innovative, Hyper-focused on saving lives. Immunologist, Virologist, Pandemic Nemesis. Posts are mine.
XairaTherapeutics @Xaira_Thera
179 Followers 10 Following An integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease
Pascal Sturmfels @PascalSturmfels
365 Followers 291 Following PhD student at @uwcse + @UWproteindesign working on machine learning for protein design, protein language models, etc.
Bingxu Liu @BingxuL
461 Followers 919 Following Postdoc @UW IPD David Baker group. PhD @mit bio, Darrell Irvine lab and Nir Hacohen lab.
Anish Mulchandani @AnMulchandani
142 Followers 263 Following Aspiring protein designer. Undergrad @IISERPune.
Cole DeForest @coledeforest
4K Followers 2K Following Weyerhaeuser Associate Professor of Chemical Engineering & Bioengineering, University of Washington | Husband | Father | Outdoor Enthusiast
Ryan Kibler @kribler
146 Followers 127 Following Protein whisperer and resident 3D printing artist @UWproteindesign
Florian Praetorius @FloPraetorius
558 Followers 194 Following Biomolecular designer; currently postdoc @UWproteindesign; starting my lab @ISTAustria in March 2024 @flopraetorius.bsky.social
Khmelinskaia Lab @akhmelinlab
372 Followers 153 Following The group of Protein Design 🧬 and Self-Assembly @LMU_Muenchen, Germany
Green Research Group @GreenGroupMIB
764 Followers 48 Following Student-run account for the Green group (MIB). Enzyme design. Directed evolution. Genetic code expansion. Metalloenzyme engineering. Industrial biocatalysis.
Green Ahn @Green_Ahn
471 Followers 195 Following Postdoc in David Baker’s Lab at IPD @UWproteindesign. PhD w/ @CarolynBertozzi @Stanford #TPD
Davian Ho @iceindavain
173 Followers 2K Following
Lucas Arnoldt @Lucas_Arnoldt
232 Followers 663 Following Bioinformatics Student @ Uni Heidelberg | Intern at @UWproteindesign | Interested in Digital Health, Deep Learning, Protein Design & Synthetic Biology.
Andres Ardon @shepargon
3K Followers 1K Following Researching protein design @UWproteindesign, discussing biosecurity @UN_Disarmament, and supporting @iGEMcommunity.
Paul T Kim @paultkim_ipd
524 Followers 409 Following PhD Student, @UWproteindesign - excited to work on machine learning methods for rational protein design. Also core @DNADeviants.
Fundación BBVA @FundacionBBVA
7K Followers 564 Following Impulsamos el conocimiento a través del apoyo a la investigación científica y la creación cultural. Reconocemos el talento y la excelencia.
CHARM Therapeutics @CHARMTherapeutx
995 Followers 1K Following Discovering & developing small molecule medicines against difficult-to-drug targets with our proprietary 3D deep learning-enabled platform, DragonFold
Sanjay Srivatsan @SRsrivatsan
2K Followers 3K Following Assistant Professor at @fredhutch. Previously, @UWproteindesign, @uwgenome, and @NIAIDNews. Building sequencing tools to explore biology.
Jacob Gershon @JacobMGershon
204 Followers 230 Following The future is sustainable 🌱🦠🧪 @UWproteindesign
Elias 👾 @EliasKinfu
77 Followers 84 Following PhD student in the King lab at UW. Psalm 111:2 Biochem grad student studying viruses + stuffffff 🌲🐛👾🧬
Andrew Hunt @Andrew_C_Hunt
305 Followers 415 Following #protein enthusiast and #cellfree evangelist | @newmexicotech to @nu_chbe to @UWproteindesign | Team lead EBRC In Translation Podcast
Cameron Glasscock @cam_glasscock
516 Followers 938 Following Washington Research Foundation Postdoctoral Fellow @UWProteinDesign @WRFSeattle | Formerly @LucksLab and @DeLisaGroup | he/him
BioInnovation Institu.. @BioCPH
1K Followers 2K Following BII's Twitter account seeks to highlight the achievements of our community as well as to promote the agenda of life science innovation in the Nordics
Preetham Venkatesh @PreethamVi
525 Followers 287 Following PhD student at University of Washington. 2023 QUAD Fellow. Interested in protein design and machine learning for therapeutics. BS-MS at IISc Bangalore.
Woody Ahern @woodyahern
108 Followers 12 Following
Sam Tipps @SamTipps
381 Followers 235 Following Deep learning + vaccine design @UWproteindesign | King Lab
Ljubica Mihaljevic, P.. @Lyoobitsa
225 Followers 169 Following A scientist trying to do art | Postdoc fellow @UWproteindesign, Baker lab | Pottery 💚🏺| She/her
Jason Yim @json_yim
1K Followers 225 Following PhD student @MIT_CSAIL. Generative models, protein design.
Will Chen @wchenomics
580 Followers 633 Following @DamonRunyon Fellow at Baker lab @UWproteindesign. PhD with @JShendure. A genomicist with a biophysical lens. Genomic technology developer
Possu Huang Lab @PossuHuangLab
1K Followers 74 Following Our lab uses experimental and computational methods to design de novo proteins | @Stanford
Shunzhi Wang @wang_shunzhi
558 Followers 491 Following Postdoc @UWproteindesign | @CHADNANO alum | De novo protein designs for programmable self-assembly | Colloidal crystal engineering with DNA
ISCRM at UW @UWISCRM
1K Followers 437 Following The Institute for Stem Cell and Regenerative Medicine at the University of Washington is changing the way human beings confront chronic disease.
Linna An @alchemist_an
265 Followers 212 Following Protein designer @UWproteindesign & natural product biochemist @ChemistryUIUC
Amir Motmaen @AMotmaen
510 Followers 438 Following Exploring the applications of ML/DL/RL for intelligent design of SynBio systems. BioE Grad Student at Baker lab @UWproteindesign 🧑🏻🔬🔬🏳️🌈
Susan Kleinfelter she.. @SKleinfelter1
397 Followers 590 Following Protein modeling nerd, Foldit fangirl, grad student at UW BPSD!
Julius Wenckstern @j_wenckstern
175 Followers 400 Following Protein Design and Structure Prediction.
Jacob North @picodase
89 Followers 438 Following University of Washington BPSD PhD candidate in the DiMaio lab. Want to model and engineer complete catalytic competency into de-novo enzymes using MD and ML
Helen Eisenach @HelenEisenach
635 Followers 269 Following @UWproteindesign Baker & King labs | @Harvard alum | interested in novel nanomaterials and machine learning | views my own
Gizem Gökçe Alpkıl.. @gizemgokce92
102 Followers 136 Following Fulbrighter 🇹🇷 🇺🇸 University of Washington 💜 - PhD Candidate, Bhardwaj Lab @UWproteindesign TOBB ETU - Biomedical Engineering BSc & MSc
Inca Dieterich, PhD @IncaDieterich
372 Followers 419 Following building at ARCH | co-founder at Rippl & Vilya | tweeting about science, aging, digital & mental health | neuroscience PhD | outdoor trekker
AI Proteins @AI_Proteins
2K Followers 22 Following better medicines, created rapidly through de novo protein design
Microsoft Research @MSFTResearch
553K Followers 2K Following We advance science and technology to benefit humanity. https://t.co/kz0nARXbwT Register for Microsoft Research Forum on June 4 ⬇️ Get our newsletter
Amijai Saragovi @AmijaiSaragovi
214 Followers 1K Following Proteins designer by day, Angel investor (a small one) by night. Interested in non-conventional biotech, ecotech and anything super-creative
#AI -powered protein design is used to create new therapeutics, vaccines, biosensors, materials and more. The field is moving fast, and @UWMedicine's @UWproteindesign research is behind many of the advances. bit.ly/4aS5ULU
“I believe this collaboration between a stem cell institute, a dental school, and experts in genetic sequencing and protein design could only happen in a few places, and one of them is in Seattle.” @UWDentalSchool @RuoholaL @UWproteindesign @BrotmanBaty bit.ly/4aIfBMT
Interested in Generative AI for BIO? Please Join George Church, David Baker and Sarah Carter for an interactive SynBioBeta Town Hall on "Generative AI for Protein Design: Balancing Risks with Opportunities". Tuesday Apr 16th at 12 noon pacific. You can register here:…
@definitelyphil @naterbennett0 @_JosephWatson @RobertRagotte @andrewjborst @dejsee @UWproteindesign Very cool stuff this!
Excited to share the release of our pre-print unveiling the design of de novo single-domain #antibodies with atomic-level precision, as revealed by #CryoEM! @UWBiochemistry @UWproteindesign Work co-led by @_JosephWatson @naterbennett0 @RobertRagotte biorxiv.org/content/10.110…
@definitelyphil @naterbennett0 @_JosephWatson @RobertRagotte @andrewjborst @dejsee @UWproteindesign Congrats!! Super cool work
Amazing progress!
We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
Here comes the antibody design with RFDiffusion!
We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
Very excited to see this work! 👍
We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
These diffusion designed proteins are the most sci fi thing to come out of AI. I could imagine watching something like this in a Marvel movie a few years ago, I would have scoffed and rolled my eyes.
We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!
@dejsee @wanderingriti @definitelyphil @SingerBenedikt ... Dionne Vafeados, Mariana Garcia Sanchez, Ho Min Kim, @SusanaVazTor and Sidney Chan. Thanks also to. @ichaydon for making the VHH diffusion graphic! And thanks to everyone at @UWproteindesign for making projects like this possible. Great collaborations are so good for science!
Thanks, as always, to David Baker, and to all the coauthors who helped make this project a reality @dejsee, Connor Weidle, @wanderingriti, Ellen Shrock, @definitelyphil, Buwei Huang, Inna Goreshnik, Russell Ault, Kenneth Carr, @SingerBenedikt, Cameron Criswell...
This work *does not* solve drug design, but it shows for the first time that accurate antibody design is possible. Hopefully this work will lay the groundwork for future developments. I hope one day that making therepeutic antibody will be as easy as pressing “go”!
The question was though, would these antibodies actually work? @RobertRagotte and @andrewjborst, co-lead authors on the study, led the experimental effort. We designed VHH binders to four unrelated targets. A structure of one of them shows that it binds almost exactly as designed
Antibodies have many advantages as therapeutics, and are as such the biggest class of therapeutics globally. However, to date, design of structurally accurate novel antibodies has not been demonstrated. We wondered if generative models like RFdiffusion could be the answer.
We therefore built upon RFdiffusion to train a generative model specifically for antibody design. This model is capable of designing diverse and truly de novo antibodies.
These binders typically bound via rigid secondary structure-based interactions, however, which contrasts to how nature has “solved” the binder design problem. Nature uses antibodies to bind to targets, which interact with proteins through more flexible CDR loops.
RFdiffusion excels at protein interface design (making a binder to something). We demonstrated very high experimental success rates in the paper, and across the Institute for Protein Design scientists were making binders to historically extremely challenging targets.
This project grew out of discussions with my friend and co-lead author @naterbennett0 last year. As a reminder, last year we published and released RFdiffusion: x.com/UWproteindesig…
Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. bakerlab.org/2023/03/30/rf-…
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