Trace Henry @_Trace_Henry
Med Affairs @AdaptiveBiotech | Occasional thoughts https://t.co/G5mUQHleTZ | UMich PhD @UM_MNI Joined April 2009-
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Mathematician and genius John Conway, inventor of The Game of Life has succumbed to COVID-19 today. What a terrible loss for the world. RIP.
New modular ion channels and selective, sub-nanomolar potency agonists (uPSEMs) were developed from Scott Sternson's lab @HHMIJanelia. This system is effective in the brain of rodent and primate models. #chemogenetics hubs.ly/H0h9V8c0
In collab. w/ @OICE_Imaging we present an animated transformation of a growing #zebrafish nervous system via 3Dscript, imaged on a custom-built #lightsheet microscope. While the time-lapse progresses, the image volume is spatially transformed. Read more: nature.com/articles/s4159…
10,000 compound, multibehavioral zebrafish screen to ID neuroactive drugs w/ appetite modulating effect. With validation in mice! advances.sciencemag.org/content/4/10/e…
Our new perspective suggesting that 3D chromatin organization is an emergent property of chromatin-bound proteins was just published nature.com/articles/s4157…
Our paper describing improved CaMPARI variants for marking neuronal activity is out: rdcu.be/92hc We also describe an antibody that is selective for the photo converted (red) form. Reagents are available, let us know how we can help!
Say you pick 100 random bioinformatics software tools -- how many will you actually be able to access, install, and run? Our new paper: biorxiv.org/content/early/…
Say you pick 100 random bioinformatics software tools -- how many will you actually be able to access, install, and run? Our new paper: biorxiv.org/content/early/…
Our preprint describing how adaptive disinhibitory gating by VIP interneurons supports associative learning is now online: biorxiv.org/content/early/… @FMIscience @imed_tweets
'a library of 230 AAVs. ~11% target expression to neuronal + glial cell types in mouse retina, mouse brain, non-human primate retina in vivo, and in human retina in vitro... recording, stimulation, characterization, intersectional labeling of cell types' biorxiv.org/content/early/…
Thread: A picture is worth a thousand words, and your brain needs billions of neurons to process it. Why do we need so many neurons? To find out, we recorded thousands of them in mouse visual cortex. Here’s some data, and a link to the paper: biorxiv.org/content/early/…
And, a preview of what the whole fly brain EM dataset's user community has been up to while we rewrote, etc. ~5 mm traced cable length shown here! beautiful visualization by @uni_matrix, somewhat mangled by my downsizing & trimming to only 180° rotation #ASAPbio #bioRxiv
More evidence for presynaptic translation from the Schuman Lab: biorxiv.org/content/early/…. Follows a spate of recent articles from other groups describing molecular components (sciencedirect.com/science/articl…) and unique functional contexts (sciencedirect.com/science/articl…)
At long last, in Nature, from our lab and Lew Cantley's lab.. can diet be used as a drug ? For centuries, it was the ONLY drug... why not reinvent diet ? For cancer patients ? nature.com/articles/s4158…
I read the paper regarding "volume transmission" theory when I was grad-student, and I thought "haa, interesting". It is still alive, and looks like important for energy homeostasis /cell.com/cell-metabolis…
Our latest @biorxivpreprint What are the candidate genes in schizophrenia-associated loci? What are their functions? Phenotypic atlas of 132 zebrafish mutants will help answer these questions. Heroic effort by postdoc Summer Thyme et al. biorxiv.org/cgi/content/sh…
What approach(es) do you prefer for clustering #singlecell #transcriptomics data? As datasets get bigger and bigger, we will need to put more thought into runtime and memory usage. jef.works/blog/2018/06/2… #bigdata #bioinformatics #datascience #rstats #rtutorial
Wow: every tissue shows a strong correlation between mRNA&protein levels. The central dogma may be correct afterall! biorxiv.org/content/early/… A deep proteome and transcriptome abundance atlas of 29 healthy human tissues @biorxivpreprint
Suddenly my alignment issues don't seem quite so bad...
Really cool idea here: extract Ca2+ dynamics from multiple cell types via post-hoc immuno-labeling of tissue previously imaged in vivo: nature.com/articles/s4159…
Nice example of detailed smFISH for post-hoc validation of predicted marker genes from scRNAseq. This level of characterization should really be standard nature.com/articles/s4159…

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