Prashant Bhat @_prashantbhat
Uncovering the functions of genome organization | M.D. @UCLA👨🏽⚕️| Ph.D. '23 @mitchguttman @Caltech | Previously worked on #CRISPR @doudna_lab @UCBerkeley '14 guttmanlab.caltech.edu/prashant-bhat/ Pasadena and Los Angeles, CA Joined November 2017-
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Prashant Bhat retweeted
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…
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Prashant Bhat retweeted
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…
Prashant Bhat retweeted
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…
Prashant Bhat retweeted
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…
Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link: forms.gle/LopwGCc8RbuCqS…
Prashant Bhat retweeted
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…
Delighted to read this article by @TheScientistLLC featuring our work on nuclear speckles! Also features quotes from @mitchguttman and @belmont_andrew. the-scientist.com/gene-proximity…
Elegant study by @ejkk0 & @daSpliceIsRight identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter + higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!
Elegant study by @ejkk0 & @daSpliceIsRight identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter + higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!
Prashant Bhat retweeted
Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…
Prashant Bhat retweeted
How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our lab & @LafontaineLab + Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.110…
Prashant Bhat retweeted
We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA. biorxiv.org/content/10.110…
Prashant Bhat retweeted
Cheer on @UCSFDeptofEM’s Kishan Patel, MD, as he competes on @CBS #Survivor47 in the Fiji islands! This ER doctor thrives in high-pressure situations. Tune in to see how he outwits and outlasts the competition. #UCSFProud @ucsfhealth tiny.ucsf.edu/CvJpUD
I’ve had the chance to interact with all of these amazingly bright and kind humans - congrats to all on their amazing PhDs from @lpachter lab! Go @Caltech!
Prashant Bhat retweeted
Now Online Splicing regulation through biomolecular condensates and membraneless organelles dlvr.it/T7Bmcw
It was fun to present at my first @RNASociety meeting in Edinburgh! Thanks to the organizers for a great meeting and the audience for the engaging questions! #RNA24 Want to chat about speckles and splicing in different cellular contexts, including disease processes? DM me!
Prashant Bhat retweeted
Proximity to nuclear speckles–areas dense in mRNA splicing regulators–determines mRNA splicing efficiency. Variation in distance between genes and nuclear speckles drives cell-type specific differences in splicing. @_prashantbhat @mitchguttman ow.ly/cszr50RHV4h
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