Alexandre @alexandre__h
R&D Scientist | Chemistry | Biotechnology | Nucleotides | Nucleobases | Nucleic Acids | he/him | All views my own bsky.app/profile/hofale… Joined March 2018-
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Alexandre retweeted
📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/chemr…
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Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/chemr…
Alexandre retweeted
🚨Less than a week left to apply (deadline 19/03/25) for this exciting fully funded 4 Year Phd position in my group. Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT! Apply here: crick.ac.uk/careers-study/…
Alexandre retweeted
PhD opportunity @TheCrick and @kclchemistry 🚨 Are you passionate about pushing research frontiers? This project offers the chance to develop cutting-edge skills across multiple disciplines. Application deadline 19th of March!!! Retweet appreciated 🫶🏻crick.ac.uk/careers-study/…
Alexandre retweeted
@Jeannine__Hess Exciting joint PhD project availble with @Jeannine__Hess at the interface of biomedicinal chemistry and chemical biology through @The_MRC DTP. kcl-mrcdtp.com/project/ration…
Alexandre retweeted
Exciting opportunity🚨 Joint PhD position with @lab_mueller 👇🏻Application deadline 29th October 24! kcl-mrcdtp.com/project/ration… Retweets much appreciated!
Exciting opportunity🚨 Joint PhD position with @lab_mueller 👇🏻Application deadline 29th October 24! kcl-mrcdtp.com/project/ration… Retweets much appreciated!
Thanks @CambridgeIndy for publishing my view on closing the Mill Road Bridge for private vehicles.
"Prioritizing family life has earned me respect in my field — and my research has improved, too" nature.com/articles/d4158…
Alexandre retweeted
Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases | Journal of the American Chemical Society @KingsCollegeLon #Peptide #Cyclization #Modular #Logic #Nonribosomal #Synthetases pubs.acs.org/doi/10.1021/ja…
Alexandre retweeted
Our scientists have discovered a rapid method of making cyclic peptides - an important class of antibiotic molecules! ⭕ 🦠 The approach could speed up efforts to produce new antibiotics in the fight against #AntimicrobialResistance Find out more 👇 loom.ly/kDRYpR4
Alexandre retweeted
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry! Support by sharing!
Alexandre retweeted
🚨🚨🚨Exciting opportunity to join our labs @impchemistry and @TheCrick and work on an exciting project! RT appreciated. #chemtwitter
Alexandre retweeted
🚨🚨🚨 Exciting PhD opportunity to join Sasi Conte's lab and mine @KCLBMBioscience and @TheCrick on an adventure of identifying new RNA-protein inhibitors! Deadline 9th of November 🔔🔔 #chemjobs RT highly appreciated! crick.ac.uk/careers-study/…
Structures-Who-Cannot-Be-Named and other wizardry in this paper ⬇️
Alexandre retweeted
Did you know that bacterial #viruses glue #RNA to proteins? We discovered that a T4 #phage #ART links NAD-RNA to E. coli proteins. We call this an #RNAylation. Great collaboration with @JaeschkeLab and Urlaub Lab. Congratulations to @MaikSchauerte 🍾 nature.com/articles/s4158…
Alexandre retweeted
This WWF ad is genius.
TCIP, Transcriptional/epigenetic chemical inducers of proximity – or how to use proximity-inducing small molecules to re-activate apoptosis in cancer cells. nature.com/articles/s4158…
Alexandre retweeted
Looking for some Friday morning reading☕️🫖? Our new review discusses metal-specific modes of action of antibacterial candidates. Nicely put together by @JessicaWaters11 @CullinaneLars Lukas Siebenmann sciencedirect.com/science/articl…
A mechanochemical phosphorylation to make phosphonates from polyphosphate: pubs.acs.org/doi/full/10.10…
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