Amit Sud @amit_sud
haemato-oncologist & @wellcometrust early career fellow. @DanaFarber @broadinstitute @harvardmed @UniofOxford @ICR_London 🧬🔴🔬💻🚴🏽♂️🥁🌱🌍 scholar.google.co.uk/citations?user… Boston, MA Joined October 2008-
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Amit Sud retweeted
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new @Nature paper, Miranda Hunter found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
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Amit Sud retweeted
Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l_cmurphy below. Check out the news feature science.org/content/articl… and terrific editorial from Dennis Lo
Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l_cmurphy below. Check out the news feature science.org/content/articl… and terrific editorial from Dennis Lo
Amit Sud retweeted
Please check out or new paper describing a novel relationship between DNMT3A and telomeres. It truly was a team effort ! Even better when your former @Goodell_Lab baymate @TheKingLab publishes in @CellStemCell in the same issue!
Please check out or new paper describing a novel relationship between DNMT3A and telomeres. It truly was a team effort ! Even better when your former @Goodell_Lab baymate @TheKingLab publishes in @CellStemCell in the same issue!
Amit Sud retweeted
📜New in @ScienceMagazine: not one but two papers from team MATCHMAKERS! The labs of David Baker @UWproteindesign and Chris Garcia @StanfordEMED published work that could revolutionise immunotherapy. The Baker lab unveil a generative AI pipeline to design precise binders for…
Amit Sud retweeted
🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @ScienceMagazine! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.
Amit Sud retweeted
1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇
Amit Sud retweeted
1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too…
Amit Sud retweeted
Detecting Foldback Artifacts in Long Reads biorxiv.org/content/10.110… #biorxiv_bioinfo
Amit Sud retweeted
Incidental vs. symptomatic diagnosis of follicular lymphoma: implications of earlier detection | Blood Cancer Journal @MayoCancerCare nature.com/articles/s4140…
Amit Sud retweeted
Researchers have been sneaking secret messages into their papers in an effort to trick AI tools into giving them a positive peer-review report Read the full story: go.nature.com/4eVTIwC
Amit Sud retweeted
Meet RESOLVE, our new method for mutational signature analysis just published in Nucleic Acids Research! Applied to 20,000 adult and pediatric cancers, it reveals key links to driver mutations and clinical outcomes. 🔗 doi.org/10.1093/nar/gk… #CancerGenomics #MutationalSignatures
Amit Sud retweeted
Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. msft.it/6010S7T8n
Amit Sud retweeted
Never stop being a proud physicist @DimaKrotov , it's a pleasure working with you 🥳. research.ibm.com/blog/dmitry-kr… "Computation is a physical process. We can study the flow of bits just as we study the flow of atoms" More juicy Dima snippets in 🧵
Amit Sud retweeted
When #AlphaFold2 came out, we wondered: Could it help us understand how enzymes evolve? So we tried it—and it worked! nature.com/articles/s4158…
Amit Sud retweeted
Our new work @biorxivpreprint 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. @semeigazin @katsu_s_minami @MasaAShimazoe
Amit Sud retweeted
cc. @Jimllpaintit
Amit Sud retweeted
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158…
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158… https://t.co/nMmfCBswlK
Amit Sud retweeted
Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
Amit Sud retweeted
Here's a new, very exciting paper from our #CDlab: cell.com/cell-reports/f… Here, Brian Analikwu, Alice Deshayes et al show that dense linear protein arrays (such as telomeres) stop loop-extruding SMC motors! Great collaboration with Marcand lab. see bsky.app/profile/ceesde…
Amit Sud retweeted
New preprint: Allostery is a widespread cause of loss-of-function variant pathogenicity by the great @liao_xiaotian biorxiv.org/content/10.110….
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