Amit Agrawal @amitmechaging
Decoding immune system's role in aging| Postdoc @YosefLab | @WeizmannScience (Systems Immunology) | @UCBerkeley (EECS) mechanismofaging.com Weizmann Inst. Science Joined March 2012-
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Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional), we mapped week-by-week changes starting from preconception to months-long postpartum recovery.
The power of Longitudinal studies for comprehensive view of physiology and pathology. How pregnancy changes our body? Can systemic inflammaging precedes cancer diagnosis? Check out below.. science.org/doi/10.1126/sc… doi.org/10.1073/pnas.2… @UriAlonWeizmann @mark M Davis
Last sunset before we kick off #SCG24! Truly excited to engage with the global single cell family. Wondering about what Harreman, Nativ and CytoVI mean? Come by our posters!
📑: @JuliaMMagdalena @amitmechaging et al fr/@KrizhanovskyLab show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1, by downregulating its proteasomal degradation to accumulate in ageing and chronic inflammation. nature.com/articles/s4155…
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells nature.com/articles/s4155…
Immunotherapy as an anti-aging treatment? @KrizhanovskyLab we show that immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! @amitmechaging @UriAlonWeizmann @IdoAmitLab @WeizmannScience nature.com/articles/s4155…
Congrats @JuliaMMagdalena @amitmechaging . Thanks @UriAlonWeizmann for great collaboration.
Congrats @JuliaMMagdalena @amitmechaging . Thanks @UriAlonWeizmann for great collaboration.
Morphological features of the skin can predict aging with a mean absolute error comparable to state-of-the-art epigenetic clocks. Download our paper here: biorxiv.org/content/10.110…
Quantifying the stochastic component of epigenetic aging nature.com/articles/s4358…
Congratulations @NRachmian for this elegant study on senescent microglia in Alzheimer's disease published at @NatureNeuro. Exciting collaboration with Michal Schwartz and the first study from our lab on the role of senescence in neurodegenerative diseases.
Congratulations @NRachmian for this elegant study on senescent microglia in Alzheimer's disease published at @NatureNeuro. Exciting collaboration with Michal Schwartz and the first study from our lab on the role of senescence in neurodegenerative diseases.
Judy will always be remembered as scientific giant who pioneered the senescence field. Her conceptually transformative work provided the basis of the tremendous progress from mechanisms to therapies. Judy will be dearly missed by all of us. Rest in peace.
Judy will always be remembered as scientific giant who pioneered the senescence field. Her conceptually transformative work provided the basis of the tremendous progress from mechanisms to therapies. Judy will be dearly missed by all of us. Rest in peace.

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