Evelyn Jagoda, PhD👩🏻🔬 @evelynjagoda
Research Scientist at the Broad Institute w/ PhD in Human Evolutionary Biology. Connecting the non-coding human genome to biology and disease. Cambridge, MA Joined January 2019-
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Excited to share our collaboration with ENCODE to map enhancer-gene regulatory interactions across the human genome! We developed a new model that beats ABC by incorporating additional information on promoter class and enhancer-enhancer interactions. Thread 👇
Excited to share our collaboration with ENCODE to map enhancer-gene regulatory interactions across the human genome! We developed a new model that beats ABC by incorporating additional information on promoter class and enhancer-enhancer interactions. Thread 👇
So glad we can finally share this! Proud to be part of this wonderful team!
So glad we can finally share this! Proud to be part of this wonderful team!
Neanderthal inheritance makes people more vulnerable to severe Covid-19. More on this in my latest for @NatureItaly ! @TDCapellini @CBUuniTo @Harvard #Neanderthal #COVID19
Neanderthal inheritance makes people more vulnerable to severe Covid-19. More on this in my latest for @NatureItaly ! @TDCapellini @CBUuniTo @Harvard #Neanderthal #COVID19
If anyone knows of any data science / pop gen positions in industry please get in touch! NYC area or remote. @Color laid off ~50% of the company. Genomics R&D work basically out. Frustrating news, but proud of my contributions and grateful for all I learned & great colleagues.
"There is grandeur in this view of life—that from so simple a beginning, endless forms most beautiful and most wonderful have been, and are being, evolved." Happy birthday to the one and only Charles Darwin. #DarwinDay
We are hiring! Join us in Engreitz Lab @ Stanford to map the regulatory wiring of the genome to understand the genetic basis of heart diseases Multiple roles: Experimental and/or computational. Multiple levels: post-bac, postdoc, staff scientist engreitzlab.org/join 1/
Beautiful example of how insights into genetic linkage of human alleles—originating via introgression from Neandertals—can accelerate identifying the genetic causes of health outcomes today: in this case, severe Covid-19. @evelynjagoda @TDCapellini elifesciences.org/articles/71235
Really excited for people to check out this work! So glad I got to collaborate with an amazing group of scientists!
Really excited for people to check out this work! So glad I got to collaborate with an amazing group of scientists!
Very proud to have contributed to this publication!
Very proud to have contributed to this publication!
Awesome news!
Excited to share our latest work on enhancer-promoter compatibility in preprint form! Compatibility logic of human enhancer and promoter sequences biorxiv.org/content/10.110… With an amazing team: co-first author @ThouIs, @jengreitz, @FulcoCharles and more 🧵👇 1/15
Advanced access for our publication is out in today! We use MPRA to identify introgressed Neanderthal variants that affect gene expression in immune cells and use TF binding, GWAS data, and CRISPR KOs to connect variants to immune function. Thx to @TDCapellini and all co-authors!
Advanced access for our publication is out in today! We use MPRA to identify introgressed Neanderthal variants that affect gene expression in immune cells and use TF binding, GWAS data, and CRISPR KOs to connect variants to immune function. Thx to @TDCapellini and all co-authors!
Our genome-wide functional screen of 3’UTR causal variants in human disease + evolution, using an MPRA for UTRs is out at @CellCellPress! An amazing team: @dsgriesemer, @r_tewhey, J. Xue, and @PardisSabeti, with new highlights since our preprint: cell.com/cell/fulltext/… 1/11
Check out this thread by another colleague explaining how even the biology of sex is complicated!
Check out this thread by another colleague explaining how even the biology of sex is complicated!
As a person in @HarvardHEB whose gender expression does not fit within the binary, it means a lot to me to have @LauraSimoneLew stand up for gender inclusive language in scientific and medical communication…of course she’s getting tons of hate from the trolls for it 🙄.
As a person in @HarvardHEB whose gender expression does not fit within the binary, it means a lot to me to have @LauraSimoneLew stand up for gender inclusive language in scientific and medical communication…of course she’s getting tons of hate from the trolls for it 🙄.
ICYMI it’s not too late to donate to our #juneteenth and #pride fundraiser for the Black Trans Advocacy Coaltion👇🏼
ICYMI it’s not too late to donate to our #juneteenth and #pride fundraiser for the Black Trans Advocacy Coaltion👇🏼
In honor of both Juneteenth and Pride, please consider donating to my and @LauraSimoneLew’s fundraiser for the Black Trans Advocacy coalition!! blacktrans.org/campaigns/june…
Terence Capellini @TDCapellini
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338 Followers 612 Following 👩🏻🏭 Making the world a little more accessible. 👩🏻💼 Google Creative Lab 👩🏻🎓 ColumbiaOur latest in @Nature: Convergence of coronary artery disease genes on endothelial cell programs nature.com/articles/s4158… Incredible work led by Gavin Schnitzler and @kanghelenyihua — a long-standing partnership between our lab and @Dr_RajatGupta My comments below: 1/
A new story from the lab: Rewriting regulatory DNA to dissect and reprogram gene expression biorxiv.org/content/10.110… Using CRISPR prime editing and new readout tech, we tile mutations across regulatory elements and design small edits to turn gene expression up or down! 👇👇
Excited to share the first part of my PhD in the @jengreitz lab, co-led with @gabmartyn. We developed and applied Variant-FlowFISH, a new high-throughput technology to measure the quantitative effects of hundreds of designed DNA edits on gene expression doi.org/10.1101/2023.1…
Excited to share our collaboration with ENCODE to map enhancer-gene regulatory interactions across the human genome! We developed a new model that beats ABC by incorporating additional information on promoter class and enhancer-enhancer interactions. Thread 👇
Excited to share our latest work on bioRxiv! biorxiv.org/content/10.110… A highly collaborative effort with @ksmualim @karbalayghareh, @mayayayas, @kanishkadey, @evelynjagoda,@WangXijhu, @LarsMSteinmetz, @anshulkundaje, @jengreitz and many others from @ENCODE_NIH! Thread👇
Super excited to take a look! biorxiv.org/content/10.110…
Nice piece on our work with @evelynjagoda @sci_questions and so many others!
Neanderthal inheritance makes people more vulnerable to severe Covid-19. More on this in my latest for @NatureItaly ! @TDCapellini @CBUuniTo @Harvard #Neanderthal #COVID19
@TDCapellini @evelynjagoda @eLife Great work! Congratulations Evvie and Terry!
me and the gang heading to do some BSL-3 work
"There is grandeur in this view of life—that from so simple a beginning, endless forms most beautiful and most wonderful have been, and are being, evolved." Happy birthday to the one and only Charles Darwin. #DarwinDay
Thrilled to share my first publication @NatureComms! We found >6000 TFBSs under accelerated evolution in primates using a pooling-based approach GroupAcc. nature.com/articles/s4146…
44 years ago today, our native country fell into darkness. Hoping this year brings light and solidarity #zanzendegiazadi
Great work! Perturb-seq on 42 cleavage/polyadenylation regulators with 3' scRNA-seq to infer polyA site usage + Sequence-based deep learning model to predict the perturbation responses and reveal the cis-regulatory code Cool ensemble-based multi-task perturbation network 👌
#strikes are part and parcel of what makes us human. Join us on the picket line today! @ucu #strike #ucuRISING
@sheinalew Well ok then! it's how we became human -- on the picket line. Source of all human solidarity and consciousness ✊✊✊ We did this talk on the World's First Picket Line a while back vimeo.com/761202065
MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations buff.ly/3IemRnL #science #evolution #biology #genome #SciComm #evolgen_paper
👇Check out this great collaboration by @TDCapellini, @evelynjagoda and our Davide!👏🧬🧪💻#Neanderthal #COVID19
1/10. Pleased to see our latest work by the awesome @evelynjagoda and Davide Marnetto is out in @eLife on identifying causal variants at a major COVID-19 risk locus introgressed from Neandertals and under adaptive evolution in humans. elifesciences.org/articles/71235
We are hiring! Join us in Engreitz Lab @ Stanford to map the regulatory wiring of the genome to understand the genetic basis of heart diseases Multiple roles: Experimental and/or computational. Multiple levels: post-bac, postdoc, staff scientist engreitzlab.org/join 1/
Bringing this old meme back for good times #RStats
@johnhawks @evelynjagoda Thanks John! It was a concerted effort amongst a great group of collaborators! Hopefully, more work can be done to study these variants in vivo
I have so much stuff to do. Work I really really care about. But the future of our sector is at stake. That's why I'm on #strike today. #ucuRISING
Beautiful example of how insights into genetic linkage of human alleles—originating via introgression from Neandertals—can accelerate identifying the genetic causes of health outcomes today: in this case, severe Covid-19. @evelynjagoda @TDCapellini elifesciences.org/articles/71235