Adrian Gervais @grvsadrian
PhD @casanova_lab, @InstitutImagine. @AgroParisTech, @UnivParisSaclay & @univ_paris_cite alumni. Auto-antibodies, viruses, innate immunity, IEIs🔬 Paris, France Joined June 2023-
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The Phenocopies of IEI session at #ESID2024 features experts Steve Holland, @anne_puel, @BenHalePhD, Aude Magerus, Sophie Hambleton, and @grvsadrian exploring how similar phenotypes emerge from different genetic causes. #IEI #ESID
Just published in @NatureComms! We show that Usutu virus is the only mosquito-borne flavivirus to resist ISG20-mediated inhibition, thanks to a unique domain in its 3'UTR that protects its genome from degradation. A project led by @JimZPhD at @IRIM_life. rdcu.be/dVMK1
1/ Excited to report in @JExpMed more about the causes and consequences of human autoantibodies neutralizing type I IFNs through the study of a rare disease: shorturl.at/cWcCa
About 10% of people who develop severe Covid have autoantibodies to Type 1 interferon, which doesn't get diagnosed. Now there's a simple assay. It's also relevant for other life-threatening viral illnesses, and these Abs exist in ~100 million people worldwide.…
We report here in @PNASNews a simple assay to detect human type I interferon (IFN-I) deficiency. This test could revolutionize the diagnosis and management of patients with autoantibodies against IFN-I and inborn errors of immunity (IEI) affecting the IFN-I pathway!
We report here in @PNASNews a simple assay to detect human type I interferon (IFN-I) deficiency. This test could revolutionize the diagnosis and management of patients with autoantibodies against IFN-I and inborn errors of immunity (IEI) affecting the IFN-I pathway!
Thrilled to share my second first-author paper out in @JExpMed. We show that about 10% of severe tick-borne encephalitis cases are due to auto-Abs neutralizing type I IFNs. Thanks to all our wonderful collaborators!
Thrilled to share my second first-author paper out in @JExpMed. We show that about 10% of severe tick-borne encephalitis cases are due to auto-Abs neutralizing type I IFNs. Thanks to all our wonderful collaborators!
🦟 5 cas d'infections à virus du Nil occidental ont désormais été rapportés dans le Var, et plus de 70 dans toute l'Europe (dont 8 décès). L'infection, par piqûre de moustique, est généralement asymptomatique mais elle peut provoquer de rares formes neurologiques graves. 1/3
West Nile virus season in full swing in Europe Austria reports 7 West Nile virus infections after mosquito bites (Lower Austria, Burgenland), including 3 hospitalized with neurological symptoms. One imported from Hungary Several others under investigation ecdc.europa.eu/en/news-events…
The title tells it all ! Severe West Nile virus and Sars-CoV-2 infections in a patient with thymoma and anti-type I IFN antibodies pubmed.ncbi.nlm.nih.gov/38976510/
I was delighted to share my work about West Nile virus encephalitis at the @Encephalitis2023 in London! And this is an honor to be awarded with the best platform presentation🙏 I met great people in with outstanding scientific level. Thank you Ava and the team! 🧠🧑🔬🤩
#encephalitis2023 is now underway. @encephalitisava & Dr Nick Davies are leading the first session. Speakers include Dr Tarun Dua @WHO , Dr Sophia Michael, Dr Christine Strippel, @grvsadrian & Dr Tina Damodar. Excited to hear what they have to say about #encephalitis research.
👏🙏🚀
I will have the great honor of presenting part of my PhD work at the @encephalitis 2023 meeting next December, in London. Thanks a lot for the amazing opportunity! 🤩
I will have the great honor of presenting part of my PhD work at the @encephalitis 2023 meeting next December, in London. Thanks a lot for the amazing opportunity! 🤩
Screening for auto-Abs neutralizing type I IFNs is key to design prevention strategies. Check out doi.org/10.1038/d43978… @grvsadrian @BarzonLuisa @ShenYingZhang1 @casanova_lab @JExpMed
Screening for auto-Abs neutralizing type I IFNs is key to design prevention strategies. Check out doi.org/10.1038/d43978… @grvsadrian @BarzonLuisa @ShenYingZhang1 @casanova_lab @JExpMed
Félicitations à @casanova_lab pour leur nouvel article dans @JExpMed ! Après leur rôle dans les formes sévères de COVID et de grippe, ils éclairent le lien des autoanticorps avec les formes sévères d'encéphalites dues au Virus du Nil @Inserm @APHP @univ_paris_cite
Félicitations à @casanova_lab pour leur nouvel article dans @JExpMed ! Après leur rôle dans les formes sévères de COVID et de grippe, ils éclairent le lien des autoanticorps avec les formes sévères d'encéphalites dues au Virus du Nil @Inserm @APHP @univ_paris_cite
One fantastic collaboration with @casanova_lab, @grvsadrian, @ShenYingZhang, and all the co-authors - just go through the thread to discover more !
One fantastic collaboration with @casanova_lab, @grvsadrian, @ShenYingZhang, and all the co-authors - just go through the thread to discover more !
1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/22…).
Very happy to share my 1st paper as 1st author! Thanks to all our amazing collaborators for this fantastic journey. More to come! #WNV #autoAbs 🤩@esiborghe @casanova_lab
Very happy to share my 1st paper as 1st author! Thanks to all our amazing collaborators for this fantastic journey. More to come! #WNV #autoAbs 🤩@esiborghe @casanova_lab
In @JExpMed, @grvsadrian et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ~40% of cases of West Nile virus (WNV) encephalitis. bit.ly/3qZIeDh @AurelieCobat @ShenYingZhang1 @casanova_lab @esiborghe
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