Explore how #macrocyclization enhances #kinaseinhibitors, improving selectivity, overcoming resistance, and optimizing #druglikeproperties. Read More: amm-journal.org/index.php/2025… #macrocyclizationstrategy #Drugdesign #Bindingaffinity #Kinaseselectivity @Science_Open @NUSingapore

Converting Amyloidogenic Islet Amyloid Polypeptide into Potent Nonaggregating Peptide Ligand by Side Chain-to-Side Chain Macrocyclization | JACS @otago @AucklandUni @sciencesUQAM @UQAM #Amyloidogernic #Polypeptide #NonAggregating #Macrocyclization pubs.acs.org/doi/10.1021/ja…

Explore the potential of #nitriles 🧪 in #macrocyclization and #bioconjugation with the latest research by @NitscheLab. The game-changing cyanopyridine–aminothiol click reaction enables selective and biocompatible peptide/protein modifications 💪 👉 brnw.ch/21wLKXA

One-Step Catalyst-Transfer Macrocyclization: Expanding the Chemical Space of Azaparacyclophanes | Journal of the American Chemical Society @BonifaziGroup @univienna #Catalyst #Macrocyclization #Azaparacyclophanes pubs.acs.org/doi/10.1021/ja…

Researchers @fudan University 🇨🇳 focus on #chemoenzymatic synthesis of macrocyclic peptides and polyketides via #thioesterase-catalyzed #macrocyclization. #biosynthesis ➡️ beilstein-journals.org/bjoc/articles/… Thanks for guest editing @LabRudolf, @barra_lena and Takayoshi Awakawa! 💎🔓 #BJOC

#Macrocyclization of Quinazoline-Based #EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR #L858R and #Del19 | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.102…

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization | Journal of the American Chemical Society @LcsoLab @EPFL_CHEM_Tweet @TotalSyntheses #Fluorescent #Cyclic #Peptides #Au #Macrocyclization pubs.acs.org/doi/10.1021/ja…

Multicopper Clusters Enable Oxidative Phenol Macrocyclization (OxPM) of Peptides | Journal of the American Chemical Society @bengurionu @PappoDoron @Totalsynth #Multicopper #Clusters #Oxidative #Phenol #Coupling #Macrocyclization pubs.acs.org/doi/10.1021/ja…

A new spotlight on #proximity-induced #one-pot #macrocyclization, where the required electrophile jumps out of the cleavage step: “It's happening like magic!” #peptidecyclization is like a piece of cake! Learn more from @AlexManicardi @GroupObcr pubs.acs.org/doi/10.1021/ac…

Tyrosinase-Catalyzed Peptide Macrocyclization for mRNA Display @BowersRangers @UNCResearch @UNC #Tyronase #Catalysis #Peptide #Macrocyclization #mRNA #Display pubs.acs.org/doi/10.1021/ja…

Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase @uncchemistry @UNCPharmacy #Genetic #Code #Expansion #Peptide #Macrocyclization #mRNA #tRNA #Synthetase pubs.acs.org/doi/10.1021/ja…

Angew. Chem. online: Total #Synthesis of #Mutanobactins A, B from the Human #Microbiome: #Macrocyclization and #Thiazepanone Assembly in a Single Step @angew_chem @isciverse @CHNSci @ETH_en @CarreiraGroup @TotalSynthesis #Chemistry #Science #Catalysis onlinelibrary.wiley.com/doi/10.1002/an…

Stimuli-Responsive Macrocyclization Scaffold Allows In Situ Self-Assembly of Radioactive Tracers for Positron Emission Tomography Imaging of Enzyme Activity @njuniversity #Macrocyclization #Radioactive #Tracers #PET #Enzyme #PositronEmissionTomography pubs.acs.org/doi/10.1021/ja…

#RecommendedPaper #InterestingPaper From Target-Oriented to Motif-Oriented: A Case Study on Nannocystin Total Synthesis By Weicheng Zhang 👉mdpi.com/1420-3049/25/2… #totalsynthesis #motiforiented #nannocystin #macrocyclization

Online NOW | @J_A_C_S Rapid #Arene #Triazene Chemistry for #Macrocyclization. This strategy should find application in various fields of chemical biology, selective drug delivery, and identification of cyclic peptide hits after library screening. pubs.acs.org/doi/10.1021/ja…

Natural #scaffolds-inspired synthesis of #CF3-substituted #macrolides enabled by Rh-catalyzed C–H #alkylation #macrocyclization. #synthesis @ELSchemistry Read it: sciencedirect.com/science/articl…

🔥 New advance article for RSC Chemical Biology! 🔥 Joshua Price @BYU et al exploring "Long-range #PEG stapling: #macrocyclization for increased protein conformational stability and resistance to #proteolysis" 🧐 Get the full #openaccess story here 👉 ow.ly/WIkz50B3l7P

✳️ Gellman and co-authors report a foldamer-catalyzed #macrocyclization of dialdehydes to form 14- to 22-membered rings. ✨ This method can be used as the key step in a total synthesis of robustol! ✨ Great work! 👏 👉 fal.cn/381Tx

✳️Great Progress in Peptide Chemistry from @MonikaRaj_lab❗👏 Monika Ray and co-workers describe a #stereoselective #macrocyclization of #peptides through click chemistry. Great job! Enjoy reading this #SYNFACT of the month❗👉✨fal.cn/37J1y✨

Last speaker for today at #flowChemistry Asia conference: Prof. Shawn Collins from the Université de Montréal about #macrocyclization processes in #flow @SelectBio