Pritesh Jain @jain_pritesh30
PhD in Computational and Systems Biology | Postdoctoral Research Fellow | Chambers Lab - Nanyang Technological University| Human and Population Genetics Singapore Joined March 2019-
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My first Postdoc paper is now out on medRxiv. We performed the largest Epigenome wide association study (EWAS) of Type 2 Diabetes in an Asian Population. Happy to receive feedback and comments!! doi.org/10.1101/2025.0…
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Pritesh Jain retweeted
A fascinating new study just published online today in @NatureMedicine reports an extraordinary case of an individual carrying the PSEN2 (p.Asn141Ile) mutation—a known driver of dominantly inherited Alzheimer’s disease (DIAD)—who remained cognitively healthy well into his…
Pritesh Jain retweeted
Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
Pacbio party at ASHG2024. @PacBio #ashg24 #pacbiostarrynight
Pritesh Jain retweeted
Excited to share this discovery: Huntington's disease is a DNA process for almost all of a cell's life. Inherited HD alleles are innocuous, just unstable – CAG repeats slowy expand throughout life, acquiring toxicity only when quite long (>150 CAGs). biorxiv.org/content/10.110…
Pritesh Jain retweeted
🧬 Our #ENCODE4 paper is out now @GenomeBiology! Dissecting uncharted regions in our DNA and their influence on our health. 🧬 Dive into the world of disease genetics and genomic "dark matter" with us as we explore our trailblazing new method. Ready? Let’s go! 🚀 🧵 #Genomics…
Pritesh Jain retweeted
PWAS Hub (pwas.huji.ac.il) A nice web tool to explore proteome-wide association study results of 99 common diseases in the UK Biobank Kelman, Zucker, et al. medrxiv.org/content/10.110…
Pritesh Jain retweeted
Great work on the genetics of Parkinson's disease in the Indian population by The Parkinson's Research Alliance of India, in collaboration with MedGenome and Denali therapeutics. Andrews, Kukkle & Menon et al. Mov Disord 2023. …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md… The authors have done a…
Pritesh Jain retweeted
We’re excited to share that the RGC-ME Browser is live! The RGC-ME Browser offers allele frequencies, ancestry estimates, constraint metrics, and transcript annotations based upon a catalog of human protein-coding variations from the exome data of ~1M individuals.
Pritesh Jain retweeted
New GWAS meta-analysis of polycystic ovary syndrome based on ~7.5k cases and ~500k controls. Peterson, Brixi, Liang et al. medRxiv medrxiv.org/content/10.110…
Pritesh Jain retweeted
Today, the flagship paper of the @uk_biobank Pharma Proteomics Project was published in @Nature. nature.com/articles/s4158… The results are fully browsable at ukb-ppp.gwas.eu. The underlying protein measures will become available to UKB researchers in the next few weeks.
Pritesh Jain retweeted
Hi everyone, Our paper about boosting the power of GWAS using polygenic scores (PGS) is just out in @NatureGenet. Please check it out here: nature.com/articles/s4158…
Pritesh Jain retweeted
Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 Chandrayaan-3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3 #Ch3
Pritesh Jain retweeted
A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from…
Pritesh Jain retweeted
An important paper on the genetic architecture of South Asians is published by a fantastic team of industry and academic researchers. I recommend you read the paper to learn about all the interesting findings. But here are some general thoughts. I am not involved in this study,…
Pritesh Jain retweeted
"Here, we discuss ethical concerns surrounding the results of genome-wide association studies for individuals, society and researchers." Great & timely review by Matthieu C. de Hemptinne & @DPosthu in @NatureNeuro nature.com/articles/s4159…
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