Now online, a study in collaboration with @LeopoldParts in which we asked how often natural variants can suppress deleterious mutations So what did we find? embopress.org/doi/full/10.15…

First, we crossed ~1000 temperature-sensitive (TS) alleles into a bunch of genetically diverse wild yeast strains to isolate segregant haploid progeny that carried the TS allele.

We then looked for cases where the segregants could suddenly grow a high temperature -- suggesting that natural variants coming from the wild strain could suppress the TS allele

We found a (to me) surprisingly high amount of suppression -> ~25% of all tested genes could be suppressed! Suppression was consistent across genes with similar function and across genetically similar yeast strains