Kevin Blake PhD 💊🧫 @kevinsblake
Scientist + Writer + Illustrator kevinsblake.com St. Louis, MO Joined September 2011-
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Kevin Blake PhD 💊🧫 retweeted
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at genomes from the NCTC historical collection now out in : microbiologyresearch.org/content/journa…
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Each week is a cycle pop media misusing The March of Progress or left-handed DNA, on and on, forever
Kevin Blake PhD 💊🧫 retweeted
The bacterial flagellum looks like a simple tail, or whip. But it’s actually a rotating motor, and perhaps the most sophisticated protein complex nature has ever evolved. In e. coli, these motors are capable of astonishing speeds; about 15,000 rpm. (The world record, according…
Kevin Blake PhD 💊🧫 retweeted
Two recent papers used deep learning to either create, or discover, new antibiotics. I'll first look at the paper that made new antibiotics from scratch (and then maybe write another post about the discovery paper.) The crazy thing about this paper, in particular, is that they…
Kevin Blake PhD 💊🧫 retweeted
For over a century, the hunt for new antibiotics has focused almost exclusively on bacteria and fungi. Today, that paradigm shifts. By coupling state-of-the-art AI with the vast, largely uncharted diversity of Archaea, we open a new frontier for molecular discovery. Our APEX…
.@nytopinion DNA is right-handed, not left-handed like this image. It's a minor thing (though maybe not so minor as a jeans commercial), but it's worth getting right.
Kevin Blake PhD 💊🧫 retweeted
In 2006, scientists isolated 500 random microbes from soil & exposed them to 21 antibiotics. On average, microbes were resistant to 7 or 8 of them. 2 strains were resistant to 15 antibiotics, incl. compounds that were entirely synthetic and recently approved for clinical use.
Don't: Blindly trust AI Do: Read old papers rachel.fast.ai/posts/2025-06-…
Are chromosomes merely a laundry list of genes? I wrote for @STCmicrobeblog about new research which finds that natural selection has organized nearly 2/3s of bacterial genes into specific positions on the chromosome 🧪🧫🧬 schaechter.asmblog.org/schaechter/202…
HMMER was essential to my research on finding new antibiotic resistance genes. It's loss will only make Americans sicker. communities.springernature.com/posts/sequence…
HMMER was essential to my research on finding new antibiotic resistance genes. It's loss will only make Americans sicker. communities.springernature.com/posts/sequence…
Kevin Blake PhD 💊🧫 retweeted
@delafuentelab, Presidential Associate Professor at @PennEngineers, is leading research that uses AI to search ancient DNA—from Neanderthals to woolly mammoths—for new antibiotics. Their findings were published in @Nature and featured in @WSJ. on.wsj.com/45uiMb7
Kevin Blake PhD 💊🧫 retweeted
Most people don’t get that “Harvard” isn’t one thing, it’s three: a fictional college, a shorthand for elitism, and a real school with smart, dedicated people The administration thinks they are attacking the first, justifying it with the second, and it’s the third who get hurt
Kevin Blake PhD 💊🧫 retweeted
When two of the same experiment get different results in different hands, that often means some critical variable wasn’t controlled for when repeated and we have an incomplete understanding of important factors at play. As we gain understanding, these results can become less…
When two of the same experiment get different results in different hands, that often means some critical variable wasn’t controlled for when repeated and we have an incomplete understanding of important factors at play. As we gain understanding, these results can become less…
Kevin Blake PhD 💊🧫 retweeted
This article taught me many new things. Its basic premise is that antibiotic resistance genes emerge in the environment first, and are often millions of years old; only later do they pass into pathogens that infect humans. But what is the evidence for this? 1. In 2006,…
This article taught me many new things. Its basic premise is that antibiotic resistance genes emerge in the environment first, and are often millions of years old; only later do they pass into pathogens that infect humans. But what is the evidence for this? 1. In 2006,…
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