Kotlarz Lab @kotlarz_lab
We aim to decipher disease mechanisms in intestinal inflammation and help children with IBD. Opinions are our own. ccrc-hauner.de/ccrc LMU Klinikum, Munich Joined December 2020-
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Congratulations to @AleixoMMuise and team! Their latest paper shows that ITGAV deficiency leads to immune dysregulation, brain abnormalities, and colitis. Following our report on TGFB1 deficiency, this study in #JEM underscores the critical role of TGF-b in intestinal homeostasis
Congratulations to @AleixoMMuise and team! Their latest paper shows that ITGAV deficiency leads to immune dysregulation, brain abnormalities, and colitis. Following our report on TGFB1 deficiency, this study in #JEM underscores the critical role of TGF-b in intestinal homeostasis
Huge thanks to @LissydeRidder, our former leader of the Scientific Task Force, and team for shaping the first ESPGHAN Research Curriculum! @ESPGHANSociety @Young_ESPGHAN #Science #TranslationalResearch
Exciting presentation by @Zilbauer_M on in-vitro pre-clinical research methodologies: from cell lines to organoid cultures. @ESPGHANSociety @Young_ESPGHAN #Science #TranslationalResearch #organoids
Big Thanks to Federica Giachero to introduce the SIG on Basic and Translational Science of the @ESPGHANSociety at the ESPGHAN Winter School @Young_ESPGHAN #Science #TranslationalResearch
Thrilled to be part of the ESPGHAN Winter School on Basic Science & Translational Research in beautiful Naples! Great to connect with friends and an inspiring group of talented, motivated young clinician-scientists. @ESPGHANSociety @Young_ESPGHAN #Science #TranslationalResearch
Exciting insights from @RobertHirten on the potential of wearable optical and sweat devices to identify digital biomarkers for predicting flares in #IBD. A promising step forward for personalized healthcare! #my_UEG #uegweek2024
Ver important initiative, thanks!
Excited to hear @bruce_sands1 sharing interesting updates on #IBD treatment with Obefazimod, which modulates immune responses via miR-12 upregulation. Promising Phase 2 trial data show efficacy and safety in #UlcerativeColitis. @my_ueg #UEGWeek2024
Great talk by Dr. Sachen! Inflammatory macrophages coexpressing IL-23 and FCGR1A are elevated in #IBD tissue. Interestingly, Guselkumab (unlike Risankizumab/Mirikizumab) may enhance the potency of neutralizing IL-23 signaling by binding to FCGR1A+ IL-23–producing myeloid cells.
Honored to hear from Marla C. Dubinsky, a pioneer in pediatric #IBD biologics research. The Phase 2 UC study on Mirikizumab over 52 weeks shows similar response and remission rates in children compared to adults. Looking forward to Phase 3! @my_ueg #UEGWeek2024 #IBD
What a lineup! Next, @PeyrinBiroulet reviews S1PR modulators in #IBD - an oral therapy showing clinically improvement in responders soon after initiation and a favorable risk-benefit profile. Still, its place in our treatment landscape needs to be defined." @my_ueg #UEGWeek2024
Grateful to @silviodanese for presenting an insightful review on IL-23 inhibitors in #IBD, highlighting their promising therapeutic potential and excellent safety profile. Appreciate your expert practical guidance on when to consider IL-23 blockade. @my_ueg #UEGWeek2024
Excellent review by esteemed colleague @SebastianZeissig on JAK inhibitors in #IBD - an effective option for (acute severe) ulcerative colitis with a solid safety profile when used with appropriate precautions and consideration of contraindications. @my_ueg #UEGWeek2024
Great presentation by @KlombergRenz showcasing comparable effectiveness of EEN and steroids in achieving clinical outcomes. Emphasizing the importance of shared decision-making when selecting therapy for children with newly diagnosed #CrohnsDisease and L1 phenotype. #UEGWeek2024
Interesting results from Dr. Noviello show that risankizumab, but not ustekinumab or vedolizumab, downregulates IL-23-induced mucosal pathogenic Th17 cells in #Crohn’s disease. The distinct mechanisms between ustekinumab and risankizumab remain puzzling ... @my_ueg #UEGWeek2024
Our fantastic colleague and collaborator Holm Uhlig presenting on our favorite topic: What can adult gastroenterologists learn from monogenic IBD? Important: Monogenic IBD can present at any age! #IBD #VEOIBD veoibd.org @my_ueg #UEGWeek2024
The Transition Readiness Score is a highly useful tool for pediatric gastroenterologists to track patient skills and readiness for transition. A great resource for ensuring smooth care transitions! @my_ueg #UEGWeek2024 #IBD
Our amazing IBDPorto group member @hankjeescher presenting on the importance of translational care. Improving transition is key, and here are 10 items linked to successful transition outcomes: @my_ueg #UEGWeek2024 #IBD
Session: IBD - A lifelong journey. Fantastic presentation by @JulsgaardMette on biologics and small molecules for IBD during pregnancy and breastfeeding, highlighting key principles of quality care. #UEGWeek2024 #IBD #pregnancy
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