📢The CHMP recommends authorising a new treatment for early #AlzheimersDisease in the EU.
Leqembi is intended for treatment of mild dementia and cognitive impairment in a restricted patient population with a specific genetic make-up.
👉 ema.europa.eu/en/news/leqemb…
🚨 Just out in Theranostics: ☢️ we developed a new microglia specific Cu64-labeled TREM2-PET radiotracer ☢️ importantly this antibody based tracer has an integrated brain shuttle system (hTfR) to cross the blood-brain barrier. thno.org/v14p6319.htm#Theranostics
Nick Fox making the case that excess brain volume loss associated with Lecanemab (or other effective mAB’s) is associated with the removal of “space-occupying” structures, as amyloid plaques occupy ~6-8% of the cortex in autopsy studies. #AAIC24
Homozygosity for R47H in TREM2 and the Risk of Alzheimer’s Disease
Another AD-relevant publication @NEJM this week.
TREM2 variants like R47H may induce partial loss of function by interfering with binding of ligands such as low-density lipoprotein (LDL), apolipoprotein E…
'Mis-localization of endogenous #TDP43 leads to #ALS-like early-stage metabolic dysfunction and progressive motor deficits'
Yiying Hu, Alexander Hruscha, Chenchen Pan...Bettina Schmid @DZNE_en @SyNergy_Cluster
bit.ly/45vRfEk
Interested in translational science? 🧪 Our team at #DZNE Munich is seeking a technician for the GA-VAX project. Your work could directly contribute to clinical trials with #C9orf72#ALS patients. Apply now and join our team! #Jobs#Researchjobs.dzne.de/de/jobs/101347…
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Visit https://t.co/yBywSiWgB1 for more info!
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March 17-21 | Copenhagen, Denmark
#KenesOriginalEvents
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