Rothstein Lab @Rothstein_Lab
Dr. Jeffrey Rothstein is a professor of neurology and neuroscience @HopkinsMedicine and is the founding director of @packardcenter. (trainee run) rothsteinlab.org Baltimore, MD Joined April 2023-
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Decoding ATXN2 Phosphocode: Structural Insights and Therapeutic Opportunities in Disease link.springer.com/article/10.100…
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Rothstein Lab retweeted
CSF total tau as a proxy of synaptic degeneration nature.com/articles/s4146…
Neurofilament light chain dynamics in the pre-symptomatic phase of amyotrophic lateral sclerosis: a case report tandfonline.com/doi/abs/10.108…
Metformin decreases RAN proteins, rescues splicing abnormalities and improves behavioral phenotypes in SCA8 BAC mice biorxiv.org/content/10.110…
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis journals.biologists.com/dmm/article/18…
TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons onlinelibrary.wiley.com/doi/10.1002/an…
Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice sciencedirect.com/science/articl…
Rothstein Lab retweeted
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo cell.com/iscience/fullt…
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis journals.biologists.com/dmm/article/18…
Rothstein Lab retweeted
Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS: Cell cell.com/cell/fulltext/…
Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924 nature.com/articles/s4159…
Rothstein Lab retweeted
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes nature.com/articles/s4159…
Urinary P75: a promising biomarker for amyotrophic lateral sclerosis neurologyopen.bmj.com/content/7/2/e0…
An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus nature.com/articles/s4200…
SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity rupress.org/jcb/article-ab…
Rothstein Lab retweeted
TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord actaneurocomms.biomedcentral.com/articles/10.11…
A Slower-Progressing TDP-43 rNLS8 Mouse Model for ALS: Implications for Preclinical and Mechanistic Studies doi.org/10.1007/s12017…
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial nature.com/articles/s4146…
Nuclear pore complex dysfunction drives TDP-43 pathology in ALS sciencedirect.com/science/articl…
Spreading alpha-Synuclein Oligomers Trigger Astrocyte Reactivity and Astrocyte-glutamatergic Neuron system dysfunction in an Age-Dependent Manner biorxiv.org/content/10.110…
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